Expression of Bone Morphogenetic Proteins in Human Lung Carcinomas

Bone morphogenetic protein-2/4 and bone morphogenetic protein receptor type IA expression in metastatic and nonmetastatic oral squamous cell carcinoma

“…In the present study, expression of BMP-2/4 was weak in the 10 (100%) control specimens analyzed, indicating that the concentration of these proteins tends to be low in normal differentiated tissues and benign pathologic processes as previously reported [10,11,13,14]. Kusafuka et al [12] also found low immunoreactivity to BMPs 1, 2, 3, 4, and 7 in normal glandular epithelium.…”

“…In addition, the effects of BMPs are cellspecific and may therefore vary between different types of tumors, even those of the same cellular origin. Langenfeld et al [10] also reported that the culture conditions of in vitro studies, as well as the concentration of intra-and extracellular antagonists, interfere with the biological activity of BMPs.…”

Bone morphogenetic protein 4 expression in multiple normal and tumor tissues reveals its importance beyond development

“…According to earlier reports, BMP4 protein expression was detected in a minority of a small panel of non-small cell lung carcinomas, but studies on the mRNA level of BMP4 did not indicate any differences between the subtypes of lung cancer. 43,44 In the case of skin, no tumor subtypes besides melanoma had been previously examined. 19 In the tumor tissue microarray, low levels of BMP4 protein expression were detected in cancers of the prostate and brain that have only been shown to express BMP4 at the mRNA level.…”

BMP4 induces an epithelial–mesenchymal transition-like response in adult airway epithelial cells

“…BMP2 is overexpressed in human lung carcinomas (Langenfeld et al 2005). BMP4 has been reported to induce senescence in A549 cells in vitro (Buckley et al 2004) and BMP pathway activation and upregulation of BMP4 occurs in allergen-induced inflammation in mouse lungs in vivo (Rosendahl et al 2002).…”