Expression of c-erbB-2 oncoprotein and the prognosis of patients with cervical carcinoma

Kim, Y. T.; Kim, Sang Wun; Yoon, Bo Sung

doi:10.1016/j.ijgo.2005.10.013

Cited by 1 publication

(2 citation statements)

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“…Similar finding were reported by Gupta et al [7] and Lakshmi et al [9]. Kim et al [18] stated that HER-2 expression in cervical carcinoma was an independent prognostic factor. In the present study HER-2 expression did not correlate significantly with grade of the tumor, stage at presentation or with presence of parametrial and lymph node involvement.…”

Section: Discussionsupporting

confidence: 88%

“…According to various studies expression of HER-2 in cervical carcinoma varied from 12.1% to 96.8%. [6][7][8][9][10][11][12][13][14][15][16][17][18] This variability may be attributed to the difference in number of cases analyzed, variation in stage of tumor and in the experimental procedure followed. Costa et al [12] reported HER-2 expression in 77% of cervical carcinomas while Lakshmi et al [9] reported HER-2 expression in 96.8% of squamous cell carcinomas of cervix.…”

Section: Discussionmentioning

confidence: 99%

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HER-2/neu expression in cervical intraepithelial neoplasia and cervical carcinoma

Joseph

2015

Int J of Biomed & Adv Res

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Objectives: 1) To study the expression of HER-2 in Cervical Intraepithelial Neoplasia (CIN) and Cervical carcinoma 2) To correlate expression of HER-2 with histological type, grade and stage of tumor. Methods: A total of 34 cases were collected during the period from October 2012 to June 2014. Clinical data was collected from medical records. The histopathology slides were analyzed and immunohistochemical (IHC) studies were done on suitable blocks with marker HER-2. Results: Thirty four specimens including 20 cases of squamous cell carcinoma (58.83%), 4 cases of adenocarcinoma (11.76%) and 10 cases of CIN (29.41%) were analyzed. HER-2 expression was noted in 7 out of 10 cases (70%) of CIN. Out of 12 poorly differentiated squamous carcinomas, 8 showed 3+ positivity and 4 showed 2+ positivity. Amongst the 5 moderately differentiated squamous carcinomas, 3 showed 3+ positivity, 1 showed 2+ positivity and 1 case showed 1+ positivity. Amongst the 3 well differentiated squamous carcinomas, 1 showed 1+ positivity and the remaining 2 showed 2+ positivity. Out of the 4 adenocarcinoma cases, 2 moderately differentiated carcinomas showed 3+ positivity and the remaining 2 well differentiated carcinomas showed 2+ positivity. All FIGO stage 4 cases showed 3+ positivity. Stronger HER-2 expression was also noted among cervical carcinoma cases with lymph node and parametrial involvement. Conclusions: The intensity of HER-2 expression increased progressively as grade of lesion increased and with presence of lymph node and parametrial involvement. All the cases under FIGO stage 4 showed strong (3+) HER-2 expression.

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Section: Discussionsupporting

confidence: 88%