Expression of cell adhesion molecules in the olfactory system of the adult mouse: Presence of the embryonic form of N-CAM

Miragall, Fernando; Kadmon, Guni; Husmann, Mathias; Schachner, Melitta

doi:10.1016/0012-1606(88)90397-1

Cited by 240 publications

(150 citation statements)

References 47 publications

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“…Developmentally regulated, alternatively spliced forms of N-CAM are also known to exist (Miragall et al, 1988;Zorn and Krieg, 1992). Expression of the VASE exon, encoding 10 amino acids situated in the fourth Ig domain, is not observed in neurons early in development.…”

Section: Discussionmentioning

confidence: 99%

Mouse Neogenin, a DCC-like molecule, has four splice variants and is expressed widely in the adult mouse and during embryogenesis

1997

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Neogenin is a member of the N-CAM family of cell adhesion molecules and is closely related to the DCC tumor suppressor gene product. Recently, it has been demonstrated that the DCC/Neogenin subfamily plays a key role in axonal guidance within the embryonic nervous system, however little is known about the function of DCC or Neogenin in non-neuronal tissues in vertebrates. To gain an understanding of Neogenin function outside of the nervous system we have cloned and sequenced the mouse homologue of Neogenin. We describe three alternatively spliced exons within the extracellular domain of Neogenin and a fourth alternatively spliced exon within the cytoplasmic domain. We further demonstrate that three of these alternatively spliced exons are developmentally regulated. Analysis of Neogenin mRNA expression showed that two distinct Neogenin transcripts are expressed at signi®cant levels in a broad spectrum of adult mouse tissues and throughout the mid to late stages of embryogenesis. In situ hybridization studies on day 15.5 mouse embryos revealed that Neogenin is expressed widely throughout the developing mouse embryo, in both neuronal and nonneuronal tissues. These observations suggests that Neogenin may play an integral role in regulating di erentiation programmes and/or cell migration events within many embryonic and adult tissues.

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Section: Discussionmentioning

confidence: 99%

Mouse Neogenin, a DCC-like molecule, has four splice variants and is expressed widely in the adult mouse and during embryogenesis

1997

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“…These were supplemented by another 19 relevant publications found in references cited. 4,[9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] The studies were divided into three types, according to their principal objectives: origin and aetiology of ENB, 9,11,15,[17][18][19]21,24,[27][28][29][30][31][32][33][34][35][36][37][38][39][40] histopathological diagnosis; 10,[12][13][14]23,37,[41][42][43][44]…”

Section: Search Strategy and Selection Criteriamentioning

confidence: 99%

“…The spherical basal cells constitute a stem-cell compartment, which confers to this tissue its peculiar ability to regenerate not only physiologically but also when damaged by trauma or environmental insults. 17,19 The basal cells express 15 neural cell adhesion molecule (NCAM) 87 and the mammalian homologue of Drosophila achaete-scute (MASH) gene. 88 These progenitor cells differentiate into olfactory neurosensory cells, which show progressive maturation from the basal membrane to the epithelial surface.…”

Section: Originmentioning

confidence: 99%

Esthesioneuroblastoma: a meta-analysis and review

Dulguerov

Allal

Calcaterra

2001

The Lancet Oncology

549

698

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Our objective was to review recent developments in diagnosis, staging, and treatment of esthesioneuroblastoma (ENB). A meta-analysis of publications between 1990 and 2000 was carried out, and studies were classified according to their main subject: origin/aetiology of ENB, histopathological diagnosis, and treatment. Data so far point to the basal progenitor cells of the olfactory epithelium as the origin of ENB. Histopathological diagnosis remains difficult and is based on results of antigen expression detected through a panel of antibodies by immunohistochemistry. RT-PCR of HASH expression could be a specific marker of ENB. Overall and disease-free survival at 5 years averaged 45% (SD 22) and 41% (SD 21) in the studies included in the meta-analysis. Survival in Hyams' grades I-II was 56% (SD 20) compared with 25% (SD 20) in grades III-IV (odds ratio 6.2). In patients with metastases in cervical lymph nodes (on average 5% of the total) survival was 29%, compared with 64% for patients with N0 disease (odds ratio 5.1). Survival according to treatment modalities was 65% for surgery plus radiotherapy, 51% for radiotherapy and chemotherapy, 48% for surgery, 47% for surgery plus radiotherapy and chemotherapy, and 37% for radiotherapy alone. The histopathological grading according to Hyams and the presence of cervical lymph-node metastases emerged as prognostic factors. A combination of surgery and radiotherapy seems to be the optimum approach to treatment. The exact role of chemotherapy in treatment protocols is still unclear. The role of elective neck dissection is unclear

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“…NCAM has the ability to incorporate long chains of polysialic acid (NCAM) conferring it anti-adhesive properties (Rutishauser, 1996). PSA-NCAM regulates CNS structural plasticity, allowing neurons to participate in plastic events such as axonal growth (Zhang et al, 1992) or synaptic reorganization (Miragall et al, 1988;Seki and Rutishauser, 1998). In adult animals, this molecule is expressed in cerebral regions that are undergoing some kind of structural plasticity, such as the hypothalamo-neurohypophyseal system (Theodosis et al, 1994), the olfactory bulb (Miragall et al, 1988) the piriform and entorhinal cortices (Seki and Arai, 1991a), the amygdala (Nacher et al, 2002b), and the hippocampus (Seki and Arai, 1991b).…”

Section: Involvement Of Psa-ncam Expression In Mpfc Neuronal Structurmentioning

confidence: 99%

“…PSA-NCAM regulates CNS structural plasticity, allowing neurons to participate in plastic events such as axonal growth (Zhang et al, 1992) or synaptic reorganization (Miragall et al, 1988;Seki and Rutishauser, 1998). In adult animals, this molecule is expressed in cerebral regions that are undergoing some kind of structural plasticity, such as the hypothalamo-neurohypophyseal system (Theodosis et al, 1994), the olfactory bulb (Miragall et al, 1988) the piriform and entorhinal cortices (Seki and Arai, 1991a), the amygdala (Nacher et al, 2002b), and the hippocampus (Seki and Arai, 1991b). Previous reports have demonstrated the existence of structural plasticity in neurons of the mPFC, namely their ability to reorganize their structure under stress conditions (Brown et al, 2005;Cook and Wellman, 2004;Radley et al, 2004), or after corticosterone administration (Wellman, 2001).…”

Section: Involvement Of Psa-ncam Expression In Mpfc Neuronal Structurmentioning

confidence: 99%

Chronic Fluoxetine Treatment Increases the Expression of PSA-NCAM in the Medial Prefrontal Cortex

Varea

Blasco-Ibáñez

Gómez-Climent

et al. 2006

Neuropsychopharmacol

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Recent hypotheses suggest that changes in neuronal structure and connectivity may underlie the etiology of depression. The medial prefrontal cortex (mPFC) is affected by depression and shows neuronal remodeling during adulthood. This plasticity may be mediated by the polysialylated form of the neural cell adhesion molecule (PSA-NCAM), which is intensely expressed in the adult mPFC. As the expression of PSA-NCAM is increased by serotonin in other cerebral regions, antidepressants acting on serotonin reuptake may influence PSA-NCAM expression and thus counteract the effects of depression by modulating neuronal structural plasticity. Using immunohistochemistry, we have studied the relationship between serotoninergic fibers and PSA-NCAM expressing neurons in the adult rat mPFC and the expression of serotonin receptors in these cells. The effects of fluoxetine treatment for 14 days on mPFC PSA-NCAM expression have also been analyzed. Although serotoninergic fibers usually do not contact PSA-NCAM immunoreactive neurons, most of these cells express 5-HT3 receptors. In general, chronic fluoxetine treatment induces significant increases in the number of PSA-NCAM immunoreactive neurons and in neuropil immunostaining and coadministration of the 5-HT3 antagonist ondansetron blocks the effects of fluoxetine on PSA-NCAM expression. These results indicate that fluoxetine, acting through 5-HT3 receptors, can modulate PSA-NCAM expression in the mPFC. This modulation may mediate the structural plasticity of this cortical region and opens new perspectives on the study of the molecular bases of depression.

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Expression of cell adhesion molecules in the olfactory system of the adult mouse: Presence of the embryonic form of N-CAM

Cited by 240 publications

References 47 publications

Mouse Neogenin, a DCC-like molecule, has four splice variants and is expressed widely in the adult mouse and during embryogenesis

Mouse Neogenin, a DCC-like molecule, has four splice variants and is expressed widely in the adult mouse and during embryogenesis

Esthesioneuroblastoma: a meta-analysis and review

Chronic Fluoxetine Treatment Increases the Expression of PSA-NCAM in the Medial Prefrontal Cortex

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