Expression of cFABP and PPAR in trophoblast cells: effect of PPAR ligands on linoleic acid uptake and differentiation

Daoud, Georges; Simoneau, Lucie; Masse, André; Rassart, Éric; Lafond, Julie

doi:10.1016/j.bbalip.2004.11.017

Cited by 45 publications

(34 citation statements)

References 76 publications

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“…Although it is argued that fatty acids can flip flop across membranes (14), a membrane-associated protein has also been directly implicated in this process (15). Indeed, linoleic acid uptake by cultured cytotrophoblast cells is a saturable mechanism indicating the involvement of facilitating proteins, not solely simple diffusion (16). This short review article assesses recent studies of membraneassociated and -intracellular proteins expressed in the placenta and capable of binding and transporting fatty acids, focusing on the essential fatty acids DHA and ARA.…”

Section: Introductionmentioning

confidence: 97%

Long Chain PUFA Transport in Human Term Placenta

Cunningham¹,

McDermott²

2009

The Journal of Nutrition

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Section: Introductionmentioning

confidence: 97%

Long Chain PUFA Transport in Human Term Placenta

Cunningham¹,

McDermott²

2009

The Journal of Nutrition

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“…The mechanisms underlying trophoblast fatty acid uptake and trafficking are largely unknown. Membrane-bound and cytoplasmic fatty acid binding proteins (FABPs) are expressed in trophoblasts, but their function in intracellular trafficking of fatty acids in trophoblasts is unknown [16]–[18].…”

Section: Introductionmentioning

confidence: 99%

The Expression and Function of Fatty Acid Transport Protein-2 and -4 in the Murine Placenta

et al. 2011

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BackgroundThe uptake and trans-placental trafficking of fatty acids from the maternal blood into the fetal circulation are essential for embryonic development, and involve several families of proteins. Fatty acid transport proteins (FATPs) uniquely transport fatty acids into cells. We surmised that placental FATPs are germane for fetal growth, and are regulated during hypoxic stress, which is associated with reduced fat supply to the fetus.Methodology/Principal FindingsUsing cultured primary term human trophoblasts we found that FATP2, FATP4 and FATP6 were highly expressed in trophoblasts. Hypoxia enhanced the expression of trophoblastic FATP2 and reduced the expression of FATP4, with no change in FATP6. We also found that Fatp2 and Fatp4 are expressed in the mouse amnion and placenta, respectively. Mice deficient in Fatp2 or Fatp4 did not deviate from normal Mendelian distribution, with both embryos and placentas exhibiting normal weight and morphology, triglyceride content, and expression of genes related to fatty acid mobilization.Conclusions/SignificanceWe conclude that even though hypoxia regulates the expression of FATP2 and FATP4 in human trophoblasts, mouse Fatp2 and Fatp4 are not essential for intrauterine fetal growth.

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“…The tissue-specific regulation of FAT/CD36 and FATP expression by PPAR has been demonstrated, with hepatic expression of FAT, and FATP under the control of PPARa, whereas in adipose tissue these proteins are controlled by PPARg [11,71,[110][111][112][113]. In contrast, it appears that FABP pm expression is not under control of PPARa and PPARg.…”

Section: Fatty Acid Uptake By the Placenta: Roles Of Pparmentioning

confidence: 88%

“…It is possible that these proteins have different roles in terms of intracellular trafficking of fatty acids in the placenta. Daoud et al reported an increased expression of L-FABP and H- FABP in placental trophoblasts during differentiation, although the increased expression of these proteins was not associated with increased fatty acid uptake by these cells [71].…”

Section: Fatty Acid Uptake By the Placenta: Roles Of Pparmentioning

confidence: 99%

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Fatty acid‐activated nuclear transcription factors and their roles in human placenta

Duttaroy

2006

Eur. J. Lipid Sci. Technol.

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Fatty acid-activated nuclear transcription factors and their roles in human placentaEmerging evidence indicates that fatty acid-activated nuclear transcription factors play very important and complex roles in placental biology. These fatty acid-activated receptors are involved at a number of different levels such as differentiation, proliferation, and hormone synthesis in the feto-placental unit. Since these receptors are also fatty acid sensors, they may be involved in placental fatty acid transport and metabolism. The present article is a review of the complex roles of peroxisome proliferatoractivated receptors, sterol regulatory element-binding proteins and liver X receptors in placental biology.

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Expression of cFABP and PPAR in trophoblast cells: effect of PPAR ligands on linoleic acid uptake and differentiation

Cited by 45 publications

References 76 publications

Long Chain PUFA Transport in Human Term Placenta

Long Chain PUFA Transport in Human Term Placenta

The Expression and Function of Fatty Acid Transport Protein-2 and -4 in the Murine Placenta

Fatty acid‐activated nuclear transcription factors and their roles in human placenta

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