Expression of E-cadherin, α- &amp; β-catenin, and CD44V6 and the subcellular localization of E-cadherin and CD44V6 in normal epidermis and basal cell carcinoma

Kooy, Angela J. W.; Tank, Bhupendra; Jong, Anton A.W. de; Vuzevski, V. D.; Kwast, Theodorus H. van der; Joost, Theodoor van

doi:10.1016/s0046-8177(99)90064-3

Cited by 26 publications

(20 citation statements)

References 26 publications

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“…These authors found, just like we did, that CD44 was largely restricted to the cell surfaces facing intercellular pouches and the cell extensions protruding into them, with an almost complete exclusion of intercellular junctions. Kooy et al (1999) reported a preferential localization of CD44 at the site of intercellular junctions and other cell contacts, which is difficult to reconcile with our findings and those of Tuhkanen et al (1998). Also in accordance with Tuhkanen et al (1998), we found that the distribution of proteoglycans was identical to that of CD44 in every respect.…”

Section: Dingemans Et Alcontrasting

confidence: 59%

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CD44 Is Exposed to the Extracellular Matrix at Invasive Sites in Basal Cell Carcinomas

Dingemans

Ramkema

Pals

2002

Laboratory Investigation

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SUMMARY:We have previously shown, by light microscopy, that the level of expression of CD44 (pan-CD44, CD44v3, CD44v5, and CD44v6) in human basal cell carcinomas is related to growth pattern and invasiveness (Br J Dermatol 1099;140:17-25). We have now studied the fine distribution of these CD44 isoforms in the same tumors using immunoelectron microscopy. Despite the strong differences in the level of expression in tumor areas with different growth patterns, CD44 was consistently found almost exclusively at intercellular surfaces, with a very strong predilection for widened intercellular pouches, ie, identical to the distribution in the normal epidermis. This prevalent distribution corroborates a role for CD44 in maintaining hyaluronan-filled spaces (J Histochem Cytochem 1998;46:241-248). However, the correlation between the presence of CD44 and the presence of such pouches was not absolute, indicating that other factors are involved as well. In contrast to the prevailing literature, we also found a weak but distinct labeling of cell surfaces facing the extracellular matrix. Interestingly, this appeared significantly elevated in the thinnest, most irregular, and usually most peripheral tumor cell strands, where it was associated with tumor cell protrusions and absence of a basal lamina. Thus, the CD44 ϩ protrusions were in direct contact with the extracellular matrix and apparently represented sites of invasion. The mechanisms that may contribute to a role of CD44 at these sites include binding of extracellular matrix components (notably hyaluronan) and several biologically active factors such as hepatocyte growth factor/scatter factor and matrix metalloproteinase 9. (Lab Invest 2002, 82:313-322).

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Section: Dingemans Et Alcontrasting

confidence: 59%

“…According to the literature, the epidermal-stromal interface is CD44 Ϫ or nearly CD44 Ϫ Hale et al, 1995;Kooy et al, 1999;Tuhkanen et al, 1998). No one therefore seems to have paid any attention to a possible significance of CD44 molecules that may be present at that site.…”

Section: Dingemans Et Almentioning

confidence: 99%

CD44 Is Exposed to the Extracellular Matrix at Invasive Sites in Basal Cell Carcinomas

Dingemans

Ramkema

Pals

2002

Laboratory Investigation

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“…Accumulation of nuclear β‐catenin and loss of membranous E‐cadherin are known to be associated with tumour progression 41 . E‐cadherin is known to be decreased in BCC 42–46 . MT1‐MMP degrades a number of cell adhesion and signalling receptors, including E‐cadherin 14 .…”

Section: Discussionmentioning

confidence: 99%

Increased immunoreactivity of membrane type-1 matrix metalloproteinase (MT1-MMP) and β-catenin in high-risk basal cell carcinoma

Oh¹,

Kim

Yoo

et al. 2011

British Journal of Dermatology

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“…The recurrent rate of squamous cell carcinoma and basal cell carcinoma was high when the Ki-67 and P53 expression was high [5]. It was reported that the expression of epidermal growth factor receptor (EGFR) was correlated with the recurrence of basal cell carcinoma [6], and that adhesion molecule CD44v6 expresses in carcinoma tissue rather than normal tissue and its infiltrating tumor cells show significantly higher expression [7,8]. In addition, there are reports that various kinds of matrix metalloproteinase (MMP) affect the progression of epidermal skin cancer [9,10].…”

Section: Introductionmentioning

confidence: 99%

Comparative analysis of immunohistochemical markers with invasiveness and histologic differentiation in squamous cell carcinoma and basal cell carcinoma of the skin

Son

Kim

Lee

et al. 2008

Journal of Surgical Oncology

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Expression of E-cadherin, α- & β-catenin, and CD44V6 and the subcellular localization of E-cadherin and CD44V6 in normal epidermis and basal cell carcinoma

Cited by 26 publications

References 26 publications

CD44 Is Exposed to the Extracellular Matrix at Invasive Sites in Basal Cell Carcinomas

CD44 Is Exposed to the Extracellular Matrix at Invasive Sites in Basal Cell Carcinomas

Increased immunoreactivity of membrane type-1 matrix metalloproteinase (MT1-MMP) and β-catenin in high-risk basal cell carcinoma

Comparative analysis of immunohistochemical markers with invasiveness and histologic differentiation in squamous cell carcinoma and basal cell carcinoma of the skin

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