Expression of E-selectin, integrin β<sub>1</sub>and immunoglobulin superfamily member in human gastric carcinoma cells and its clinicopathologic significance

Ke, Jinjing; Shao, Qin-shu; Ling, Zhi‐Qiang

doi:10.3748/wjg.v12.i22.3609

Cited by 22 publications

(18 citation statements)

References 11 publications

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“…Yashiro et al (60) suggested that ICAM-1 facilitates GC cell adhesion to immune cells, leading to immune tolerance (Table II). However, other studies have demonstrated an association between the serum levels of circulating ICAM-1 and GC tumor progression, with higher levels indicating a worse prognosis (53,61,62). On account of the contradictory results in these studies, ICAM-1 has not yet been established as a prognostic marker in GC.…”

Section: Lymphangiogenesis and Metastasismentioning

confidence: 93%

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Molecular background of the regional lymph node metastasis of gastric cancer (Review)

Zhu

Hu²,

Wei

et al. 2018

Oncol Lett

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Abstract. Gastric cancer (GC) is one of the deadliest types of cancer in the world. Lymph node (LN) metastasis is a complex and malignant behavior of GC, involving a sequence of biological processes, including decreased adherence to adjacent cells, extracellular matrix (ECM) degradation and lymphatic channel permeation. LN metastasis is directly associated with the treatment response, local recurrence and long-term survival of patients with GC. Therefore, the molecular mechanisms of LN metastasis in GC development require further investigation. Recently, a large number of clinical studies have focused on the molecular mechanisms and biological markers of tumor invasion and metastasis. However, few articles have broadly summarized LN metastasis in GC, and the molecular mechanisms of LN metastasis are not yet fully understood. In the present review, the molecular mechanisms of LN metastasis in GC will be discussed, including the following aspects: Cell adhesion and movement, ECM degradation, new vessel formation, and molecular pattern differences between metastatic LNs and the primary tumor. This review may lead to a better understanding of LN metastasis in GC, and the identification of new diagnostic markers.

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Section: Lymphangiogenesis and Metastasismentioning

confidence: 93%

“…Integrins, the principal adhesion receptors of the ECM, are vital for multicellular organisms (52). A strong association has been identified between serum integrin β1 content and tumor staging, LN metastasis and distant metastasis (53). E-cadherin (E-cad) mediates calcium-dependent cell-cell adhesion (54).…”

Section: Lymphangiogenesis and Metastasismentioning

confidence: 99%

Molecular background of the regional lymph node metastasis of gastric cancer (Review)

Zhu

Hu²,

Wei

et al. 2018

Oncol Lett

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“…Blockade of IL-8 binding to its receptor causes a decrease in tumor size, angiogenesis, tumor growth, and metastasis while promoting cancer cell apoptosis (36). ICAM-1 is highly expressed in multiple human cancers as well (37)(38)(39). Although it has not been associated with effects on cancer cell survival, ICAM-1 has been linked to both tumor progression and metastasis through its ability to mediate cell adhesion and extravagation (33,40,41).…”

mentioning

confidence: 99%

DJ-1 Enhances Cell Survival through the Binding of Cezanne, a Negative Regulator of NF-κB

McNally

Davis

Clements

et al. 2011

Journal of Biological Chemistry

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Heightened DJ-1 (Park7) expression is associated with a reduction in chemotherapeutic-induced cell death and poor prognosis in several cancers, whereas the loss of DJ-1 function is found in a subgroup of Parkinson disease associated with neuronal death. This study describes a novel pathway by which DJ-1 modulates cell survival. Mass spectrometry shows that DJ-1 interacts with BBS1, CLCF1, MTREF, and Cezanne/ OTUD7B/Za20d1. Among these, Cezanne is a known deubiquitination enzyme that inhibits NF-B activity. DJ-1/Cezanne interaction is confirmed by co-immunoprecipitation of overexpressed and endogenous proteins, maps to the amino-terminal 70 residues of DJ-1, and leads to the inhibition of the deubiquitinating activity of Cezanne. Microarray profiling of shRNA-transduced cells shows that DJ-1 and Cezanne regulate IL-8 and ICAM-1 expression in opposing directions. Similarly, DJ-1 enhances NF-B nuclear translocation and cell survival, whereas Cezanne reduces these outcomes. Analysis of mouse Park7 ؊/؊ primary cells confirms the regulation of ICAM-1 by DJ-1 and Cezanne. As NF-B is important in cellular survival and transformation, IL-8 functions as an angiogenic factor and pro-survival signal, and ICAM-1 has been implicated in tumor progression, invasion, and metastasis; these data provide an additional modality by which DJ-1 controls cell survival and possibly tumor progression via interaction with Cezanne.Lung cancer is the leading cause of cancer-related mortality in the world. It is estimated that over 215,000 new cases were diagnosed in the United States in 2008 alone (1). Of the two major types of lung cancer, 85% are non-small cell lung carcinomas (NSCLC) 2 (2). With NSCLC, the best chance for a long term cure is surgery. Unfortunately, 70% of NSCLC patients are initially contraindicated for surgery due to locally invasive or metastatic disease (3). For these patients, the current treatment options are a combination of chemotherapy and radiation. With treatment, NSCLC patients have a 5-year survival rate of 15%. It is therefore imperative to investigate new pathways to target in NSCLC. Our work in the H157 NSCLC squamous cell line has focused on the role of DJ-1.DJ-1 is associated with a spectrum of human disease. Loss of DJ-1 activity, due to inactivation by mutation or genetic deletion, causes early onset Parkinson disease with high penetrance (4). Due to the protective effects of DJ-1 against toxic insults, this association is hypothesized to be due to a protective role of DJ-1 in dopaminergic neurons of the substantia nigra (5-7). As loss of DJ-1 activity leads to neuronal cell death, increased DJ-1 activity can promote cell survival, leading to its association with human malignancies. Initial research on the role of DJ-1 in cancer showed that although DJ-1 can weakly transform cells alone, it can act synergistically in combination with Ras (8). DJ-1 is highly expressed in a number of cancer types including acute leukemia, breast, prostate, ovarian, and thyroid cancer, and NSCLC and is associated with tumo...

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“…ICAM-1 expression is known to increase in human gastric carcinoma cells as well, being a predictive factor for patients with gastric carcinoma. 56 Since non-neoplastic cells of the GI tract do not express ICAM-1, it presents an attractive target for therapeutic interventions. 57 The role of ICAM-1 in colonic neoplasms is still under research.…”

Section: Cellular Adhesion Moleculesmentioning

confidence: 99%

Review of the molecular profile and modern prognostic markers for gastric lymphoma: How do they affect clinical practice?

et al. 2012

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Expression of E-selectin, integrin β₁and immunoglobulin superfamily member in human gastric carcinoma cells and its clinicopathologic significance

Abstract: Serum E-selectin, ICAM-1 and integrin beta1 expression levels are probably related to the metastasis and relapse of gastric cancer.

Cited by 22 publications

References 11 publications

Molecular background of the regional lymph node metastasis of gastric cancer (Review)

Molecular background of the regional lymph node metastasis of gastric cancer (Review)

DJ-1 Enhances Cell Survival through the Binding of Cezanne, a Negative Regulator of NF-κB

Review of the molecular profile and modern prognostic markers for gastric lymphoma: How do they affect clinical practice?

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Expression of E-selectin, integrin β1and immunoglobulin superfamily member in human gastric carcinoma cells and its clinicopathologic significance

Abstract: Serum E-selectin, ICAM-1 and integrin beta1 expression levels are probably related to the metastasis and relapse of gastric cancer.

Cited by 22 publications

References 11 publications

Molecular background of the regional lymph node metastasis of gastric cancer (Review)

Molecular background of the regional lymph node metastasis of gastric cancer (Review)

DJ-1 Enhances Cell Survival through the Binding of Cezanne, a Negative Regulator of NF-κB

Review of the molecular profile and modern prognostic markers for gastric lymphoma: How do they affect clinical practice?

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Expression of E-selectin, integrin β₁and immunoglobulin superfamily member in human gastric carcinoma cells and its clinicopathologic significance