Expression of Eukaryotic Initiation Factor 3f Is Associated with Prognosis in Gastric Carcinomas

Cheng, Yu; Jia, C W; Li, Guanghua; Li, Honglun

doi:10.1159/000360779

Cited by 8 publications

(6 citation statements)

References 22 publications

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“…The siRNA down regulation of either eIF3c or eIF3f or eIF3m subunits pretty much destroys the entire octamer preserving only the YLC (eIF3a–b–g–i) module ( 25 ), which is still capable to promote very basic eIF3 functions that are, however, insufficient to support life of human cells ( 41 ). Hence any reports describing pathological phenotypes stemming from altered expression of these three subunits should be at least partially regarded as a failure of the dramatically compromised eIF3 complex to ensure productive general translation initiation in sick cells; like underexpression of eIF3f in gastric, melanoma and pancreatic cancers supposedly deregulating apoptosis ( 151 , 152 ), eIF3f ubiquitination and proteosomal degradation during muscle atrophy ( 153 ), overexpression of eIF3m in human cancer cell lines and colon cancer patient tissues ( 154 ), as well as overexpression of eIF3c in testicular seminoma cells ( 155 ).…”

Section: Eif3 In Human Health and Diseasementioning

confidence: 99%

Embraced by eIF3: structural and functional insights into the roles of eIF3 across the translation cycle

Valášek¹,

Zeman²,

Wagner³

et al. 2017

Nucleic Acids Research

121

138

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Protein synthesis is mediated via numerous molecules including the ribosome, mRNA, tRNAs, as well as translation initiation, elongation and release factors. Some of these factors play several roles throughout the entire process to ensure proper assembly of the preinitiation complex on the right mRNA, accurate selection of the initiation codon, errorless production of the encoded polypeptide and its proper termination. Perhaps, the most intriguing of these multitasking factors is the eukaryotic initiation factor eIF3. Recent evidence strongly suggests that this factor, which coordinates the progress of most of the initiation steps, does not come off the initiation complex upon subunit joining, but instead it remains bound to 80S ribosomes and gradually falls off during the first few elongation cycles to: (1) promote resumption of scanning on the same mRNA molecule for reinitiation downstream—in case of translation of upstream ORFs short enough to preserve eIF3 bound; or (2) come back during termination on long ORFs to fine tune its fidelity or, if signaled, promote programmed stop codon readthrough. Here, we unite recent structural views of the eIF3–40S complex and discus all known eIF3 roles to provide a broad picture of the eIF3’s impact on translational control in eukaryotic cells.

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Section: Eif3 In Human Health and Diseasementioning

confidence: 99%

Embraced by eIF3: structural and functional insights into the roles of eIF3 across the translation cycle

Valášek¹,

Zeman²,

Wagner³

et al. 2017

Nucleic Acids Research

121

138

View full text Add to dashboard Cite

show abstract

“…In particular, the strategy of inhibiting EIF3H expression may suppress the progression of GC and improve patient prognosis (131). Furthermore, EIF3F was determined to serve an important role in the recurrence of GC; increased expression rates of EIF3F in GC were associated with higher 5-year survival rates of patients (133).…”

Section: Jamms and Gcmentioning

confidence: 99%

The role of deubiquitinating enzymes in gastric cancer (Review)

et al. 2019

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The epigenetic regulation of gene expression (via DNA methylation, histone modification and microRNA interference) contributes to a variety of diseases, particularly cancer. Protein deubiquitination serves a key role in the mechanism underlying histone modification, and consequently influences tumor development and progression. Improved characterization of the role of ubiquitinating enzymes has led to the identification of numerous deubiquitinating enzymes (DUBs) with various functions. Gastric cancer (GC) is a highly prevalent cancer type that exhibits a high mortality rate. Latest analysis about cancer patient revealed that GC is sixth deadliest cancer type, which frequently occur in male (7.2%) than female (4.1%). Complex associations between DUBs and GC progression have been revealed in multiple studies; however, the molecular mechanism underpinning the metastasis and recurrence of GC is yet to be elucidated. Generally, DUBs were upregulated in gastric cancer. The relation of DUBs and tumor size, classification and staging was observed in GC. Besides, 5-yar survival rate of patients with GC is effeccted by expression level of DUBs. Among the highly expressed DUBs, specifically six DUBs namely UCHs, USPs, OTUs, MJDs, JAMMs and MCPIPs effect on this survival rate. Consequently, the association between GC and DUBs has received increasing attention in recent years. Therefore, in the present review, literature investigating the association between DUBs and GC pathophysiology was analyzed and critically appraised.

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“…81 Low expression of eIF3f in gastric cancer is significantly associated with an increased serum level of carcinoma embryonic antigen. Downregulation of eIF3f was linked to more advanced tumor stages and likelihood of recurrence, 82 suggesting it may play an important role in the progression and recurrence of this type of cancer. 83 This apparent contradiction of eIF3f being a subunit underexpressed in cancer remains to be understood.…”

Section: Cancermentioning

confidence: 99%

eIF3: a factor for human health and disease

et al. 2017

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The eukaryotic initiation factor 3 (eIF3) is one of the most complex translation initiation factors in mammalian cells, consisting of several subunits (eIF3a to eIF3m). It is crucial in translation initiation and termination, and in ribosomal recycling. Accordingly, deregulated eIF3 expression is associated with different pathological conditions, including cancer. In this manuscript, we discuss the interactome and function of each subunit of the human eIF3 complex. Furthermore, we review how altered levels of eIF3 subunits correlate with neurodegenerative disorders and cancer onset and development; in addition, we evaluate how such misregulation may also trigger infection cascades. A deep understanding of the molecular mechanisms underlying eIF3 role in human disease is essential to develop new eIF3-targeted therapeutic approaches and thus, overcome such conditions.

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Expression of Eukaryotic Initiation Factor 3f Is Associated with Prognosis in Gastric Carcinomas

Cited by 8 publications

References 22 publications

Embraced by eIF3: structural and functional insights into the roles of eIF3 across the translation cycle

Embraced by eIF3: structural and functional insights into the roles of eIF3 across the translation cycle

The role of deubiquitinating enzymes in gastric cancer (Review)

eIF3: a factor for human health and disease

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