Expression of extracellular matrix proteins in ameloblastomas and adenomatoid odontogenic tumors

Medeiros, Ana Miryam Costa de; Nonaka, Cassiano Francisco Weege; Galvão, Hébel Cavalcanti; Souza, Lélia Batista de; Freitas, Roseana de Almeida

doi:10.1007/s00405-009-0996-6

Cited by 19 publications

(23 citation statements)

References 35 publications

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“…The extracellular matrix might also influence this finding as MCs have a high affinity for the adsorption to fibronectin induced by stem cell factor (SFC) or from integrin receptors [22][23][24]. In addition, several researchers have reported the presence of fibronectin in the extracellular matrix of OTs [25][26][27].…”

Section: Discussionmentioning

confidence: 99%

Distribution of mast cells in benign odontogenic tumors

et al. 2011

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The aim of this study was to investigate the presence of mast cells in a series of odontogenic tumors. Forty-five cases of odontogenic tumors were investigated using immunohistochemistry for mast cell triptase, and differences between groups were statistically evaluated. Mast cells were present in 96% of odontogenic tumors. Mast cells present in solid ameloblastoma were observed in the tumor stroma surrounding more solid and follicular epithelial islands, with or without squamous metaplasia. The odontogenic mixoma showed few mast cells. In odontogenic tumors with a cystic structure, the mast cells were distributed throughout all areas of the lesions, mainly in keratocystic odontogenic tumor. In addition, the total density of mast cells between all odontogenic tumors showed no significant difference (p> 0.05). A greater mast cells distribution was found in keratocystic odontogenic tumor in relation to adenomatoid odontogenic tumor (p < 0.01), and when the unicystic ameloblastoma and keratocistic odontogenic tumor were compared to the odontogenic myxoma (p < 0.05). Syndrome keratocystic odontogenic tumor showed a higher mean of mast cells when compared with the other tumors of the sample. Mast cells values presented by syndrome keratocystic odontogenic tumor were significantly greater than those of the sporadic keratocystic odontogenic tumor that were not associated with the syndrome (p = 0.03). Mast cells are probably one of the major components of the stromal scaffold in odontogenic tumors. We found significant differences of mast cells between syndrome nonsyndrome keratocystic odontogenic tumors, although their distribution did not seem to have any influence on the biologic behavior of benign odontogenic tumors.

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Section: Discussionmentioning

confidence: 99%

Distribution of mast cells in benign odontogenic tumors

et al. 2011

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“…Positive reactions were observed for amelogenin, laminin, heparan sulfate proteoglycan (HSPG), collagen types I and IV, tenascin, fibronectin, and osteonectin [34][35][36][37][38] . In these studies, strong stainings have been reported in limited areas of AOTs, especially in the matrix of immature enamel present in duct-like structures and hyaline droplets, but the nature of amorphous eosinophilic material of AOTs is a matter of discussion: a dystrophic enamel-like tissue produced by neoplastic epithelial basal cells, 28 real enamel tissue, 39 or dentinoid tissue with ectomesenchymal component 40 have been evocated.…”

Section: Extracellular Matrix (Ecm) Components and Metalloproteinasesmentioning

confidence: 99%

Immunohistological Features in Adenomatoid Odontogenic Tumor: Review of the Literature and First Expression and Mutational Analysis of β-Catenin in This Unusual Lesion of the Jaws

Harnet

Pédeutour

Raybaud

et al. 2013

Journal of Oral and Maxillofacial Surgery

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Purpose: To investigate for the first time the immunohistochemical and mutational status of b-catenin in a mandibular case of adenomatoid odontogenic tumor (AOT) and to review the immunohistochemical expression data of various markers (cytokeratins, metalloproteinases, etc) in such a lesion. Materials and Methods:A case of follicular-type AOT in a young male patient was analyzed in regard to the immunohistochemical expression of b-catenin and mutations of the b-catenin gene (CTNNB1). Its expression is altered in some odontogenic tumors.Results: We found a strong cytoplasmic expression of b-catenin, but no molecular anomaly within the exon 3 of CTNNB1. b-catenin is considered to play a role in cell differentiation processes. Conclusion:Our results were consistent with previous findings in ameloblastoma and malignant odontogenic tumors. However, b-catenin alterations had not been explored in AOT so far. Further studies are necessary to understand the specific regulation of b-catenin in the AOT pathogenesis. Ó

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“…MMP and tenascin expression in odontogenic lesions have been shown in a few studies previously (4)(5)(6). Still, the relationship between MMP and tenascin expression and the biological behavior of odontogenic lesions has not yet been identified.…”

Section: Ameloblastomamentioning

confidence: 99%

Immunohistochemical Analysis of Matrix Metalloproteinases-1,-9 and Tenascin in Odontogenic Lesions

et al. 2014

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Ameloblastoma (ABL) and keratocystic odontogenic tumor (KOT) are benign odontogenic tumors with local aggressive behaviors. The purpose of our study was to compare MMP-l, MMP-9 and tenascin staining patterns between "aggressive" ameloblastoma / keratocystic odontogenic tumors and "nonaggressive" radicular cysts (RC)/ dentigerous cysts (DC). Ameloblastoma, keratocystic odontogenic tumor, radicular cyst (RC) and dentigerous cyst (DC) specimens were chosen from the archives of Gazi University Faculty of Dentistry, Department of Oral Pathology, and immunohistochemically stained with MMP-l, -9 and tenascin antibodies. The immunohistochemical expressions were noted and statistically analyzed. The ABLs and KOTs showed significantly higher MMP-l and -9 positivity than the RCs and DCs (p

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Expression of extracellular matrix proteins in ameloblastomas and adenomatoid odontogenic tumors

Cited by 19 publications

References 35 publications

Distribution of mast cells in benign odontogenic tumors

Distribution of mast cells in benign odontogenic tumors

Immunohistological Features in Adenomatoid Odontogenic Tumor: Review of the Literature and First Expression and Mutational Analysis of β-Catenin in This Unusual Lesion of the Jaws

Immunohistochemical Analysis of Matrix Metalloproteinases-1,-9 and Tenascin in Odontogenic Lesions

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