2016
DOI: 10.17219/acem/62540
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Expression of Interactive Genes Associated with Apoptosis and Their Prognostic Value for Ovarian Serous Adenocarcinoma

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Cited by 16 publications
(11 citation statements)
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“…Furthermore, DNA-PKcs expression is a prognostic predictor of nasopharyngeal cancer patients with poor survival outcomes and likely plays a role in recurrence and metastasis [ 173 ]. Elevated levels of DNA-PKcs in ovarian serious adenocarcinoma tissues are an indication of a more advanced disease and worse prognosis [ 174 ]. Increased PRKDC mRNA and protein levels were found to be significantly associated with Gleason score, tumor stage, distant metastasis, and predicted poor survival by Kaplan-Meier analysis in prostate cancer [ 95 ].…”
Section: Core Nhej Factors In Carcinogenesis and Cancermentioning
confidence: 99%
“…Furthermore, DNA-PKcs expression is a prognostic predictor of nasopharyngeal cancer patients with poor survival outcomes and likely plays a role in recurrence and metastasis [ 173 ]. Elevated levels of DNA-PKcs in ovarian serious adenocarcinoma tissues are an indication of a more advanced disease and worse prognosis [ 174 ]. Increased PRKDC mRNA and protein levels were found to be significantly associated with Gleason score, tumor stage, distant metastasis, and predicted poor survival by Kaplan-Meier analysis in prostate cancer [ 95 ].…”
Section: Core Nhej Factors In Carcinogenesis and Cancermentioning
confidence: 99%
“…Cancer is a dynamic, variable, and multistep process that marks the conversion of normal cells to malignant cells. Alterations in the apoptotic process have been demonstrated as having a strong relationship to cancer [ 10 ]. Apoptosis, an ordered and orchestrated cellular death process, usually occurs under pathological and physiological conditions [ 11 ].…”
Section: Introductionmentioning
confidence: 99%
“…DNA-PKcs has become a potential target in the anticancer strategy, and the development of specific inhibitor of this kinase could improve the treatment by sensitizing tumor cells. For example, it has been shown that the DNA-PKcs inhibitor KU60648 acts as a radiosensitizing agent for osteosarcoma 10 .…”
Section: Discussionmentioning
confidence: 99%