Expression of natural killer cell activity with CD107a on ectopic endometrium in woman with endometriosis compared with non-endometriosis

Lubis, Hilma Putri; Aldiansyah, Dudy; Siregar, Hairani; Rivany, Riza; Hariadi, Tri Sugeng

doi:10.1088/1755-1315/125/1/012189

Cited by 3 publications

(3 citation statements)

References 11 publications

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“…There were 346 endometrial cancer cases found between January 2011 and August 2016 in Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia (4). In addition, women who are diagnosed with epithelial ovarian cancer (EOC) can suffer endometrial premalignancies, and women with endometriosis have risk to endometrial cancer, whereas the Natural Kill (NK) cell is lower (5,6). Besides, vascular endothelial growth factor (VEGF) is angiogenic factor which plays important roles in the growth of endometrial cancers (7).…”

Section: Introductionmentioning

confidence: 99%

The Role of Lymph-vascular Space Invasion towards Disease of Free Survival and Overall Survival Cancer in High-Risk Endometrial Cancer Endometrioid Type Patients

2020

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Major prognostic factors of endometrial cancer include stage, age, histopathological type, grading, depth of invasion of myometrium, and presence of Lymph-vascular Space Invasion (LVSI). This study evaluated the LVSI in disease free survival (DFS) and overall survival (OS) in high-risk endometrial cancer endometrioid type. This was a retrospective study. Survival analysis using Kaplan-Maier curve, log rank test, cox-regression and logistic regression were used to determine effects among variables. Among fifty-six patients, 43% of patients were <60 years, 73% with BMI <30, 17% were multiparous, and 79% were menopausal patients. There were 32% of patients with positive LVSI. Most clinical stages were found in stage III with 31 cases (55%). Patients with positive LVSI had OS lower than patients with negative LVSI (50% vs 55.3%). There were no significant results of LVSI as prognostic factor for OS. Patients with LVSI positive had survival time of 26.5 months (20.5 -32.5). There were no significant results of LVSI as prognostic factor for DFS.Patients with positive LVSI had lower DFS than patients with negative LVSI (81.8% vs 85.7%). There were significant results of LVSI as prognostic factor for high-risk endometrioid type endometrial cancer with stage endometrial cancer with p = 0.01. LVSI acts as prognostic factor for high-risk endometrioid type endometrial cancer associated with stage endometrial cancer. However, there was no effect in DFS and OS.

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Section: Introductionmentioning

confidence: 99%

The Role of Lymph-vascular Space Invasion towards Disease of Free Survival and Overall Survival Cancer in High-Risk Endometrial Cancer Endometrioid Type Patients

2020

SRP

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“…High-risk endometrial cancers are those which endometrioid type grade 3 stage Ib, clear cell carcinoma, serous carcinoma, and stages III and IV (1,5). In addition, women who are diagnosed with epithelial ovarian cancer (EOC) can suffer endometrial premalignancies, and women with endometriosis have risk to endometrial cancer, whereas the Natural Kill (NK) cell is lower (6,7). Morever, vascular endothelial growth factor (VEGF) is angiogenic factor which plays important roles in the growth of endometrial cancers (8).…”

Section: Introductionmentioning

confidence: 99%

Outcome and Radiotherapy Side Effects of High-Risk Endometrial Cancer

2020

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The endometrial cancer is radiosensitive. Adjuvant radiotherapy is previously said that it may improve survival rate of high-risk endometrial cancer and decrease recurrences rate. This study evaluated overall survival, disease-free survival (DFS) in high risk endometrial cancer, and postradiotherapy side effects. Analytic retrospective research using medical record was conducted. During the 2013-2018 period there were 185 patients with endometrial cancer undergoing radiotherapy. Prognostic factors for OS which are statistically significant were age, BMI, LVSI, stage, waiting time interval, and recurrence. The prognostic factor group of age >60 years significantly had OS (p = 0.04) and DFS-3 years (p = 0.03) which was better than that of the age group <60 years. Obese patients had OS 77% better than the non-obese group (p = 0.02). The LVSI positive group significantly had OS 0% with OR of 0.3 (95% CI 0.1-0.8) (p = 0.02) and DFS-3 years 50% (p = 0.004). Patients with waiting time intervals (queue) >9 weeks had OS 35% (p = 0.03) with OR of 3.2 (95% CI 1.1-8.8), and lower DFS-3 years (76% vs 91%; p = 0.03). Combination of radiotherapy modalities caused 61% of side effects, but statistically not significant. OS and DFS-3 years in patients >60 years old and obese were better than <60 years of age and non-obese. Positive LVSI group had poorer OS and DFS-3 years. The more side effects were due to the combination of modality.

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“…Porém, em um estudo observou-se menor expressão da proteína CD107a em tecido endometrial ectópico de mulheres com EDT, em relação ao tecido endometrial eutópico de mulheres CTRs, sem a doença (Lubis et al, 2018). A diferença encontrada entre o nosso estudo (análise por citometria de fluxo), e o estudo da literatura citado (análise por imunohistoquímica), pode estar relacionada às diferentes abordagens empregadasexpressão sistêmica e local, respectivamente -para avaliação da molécula envolvida na degranulação, CD107a.…”

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Papel de MICA na endometriose

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A versão original está disponível na Biblioteca FMUSP. São Paulo 2022À minha mãe, uma estrela nesse nosso infinito, meu maior exemplo e a minha maior inspiração.Ao meu amado Carlos, pelo seu incansável apoio neste meu sonho, e pelo carinho, em todos os momentos da minha vida.Ao meu filho Lucas, todo o meu amor. Desta minha caminhada, fica a fruto de que não há conquistas sem esforço, e que sempre há tempo para sonhar... É muito bom olhar para trás quando se consegue vislumbrar momentos tão felizes... Sozinhos construímos muito pouco. Juntos, os frutos têm um sabor muito especial.Não é sem valor que as pessoas cruzam os nossos caminhos. Algumas por uns poucos momentos, outras por um pouco mais... O que vale é a intensidade com que esses momentos são vividos.A todos, com carinho, o meu muito obrigado.A minha querida orientadora, Dra. Verônica Coelho, por sua toda dedicação ao meu aprimoramento científico. Sempre pronta a me orientar, discutir e ensinar, sem nunca medir esforços. Meu muito obrigada pelo carinho e apoio em todos os momentos desta caminhada.Seu incentivo me fez acreditar que sim, era possível! Espero poder retribuir toda essa confiança e ensinamentos adquiridos. Conte sempre comigo! Ao meu coorientador, Dr. Mauricio Abrão, pelo grande incentivo, apoio e conhecimentos recebidos. Foi a partir do grande projeto Temático em endometriose, por ele idealizado e coordenado, que eu tive a oportunidade de me juntar a sua equipe e descobrir uma nova área de conhecimento e desenvolver este trabalho. Obrigada pela confiança! Ao Prof. Dr. Jorge Kalil, com quem tenho tido a oportunidade de trabalhar por tantos anos. Obrigada pelo apoio e conhecimentos recebidos, e por sempre acreditar em mim.Espero poder contribuir sempre mais. À Dra. Luiza Guilherme, Dr. Edécio Cunha-Neto e Dra. Keity Santos pelo incentivo, amizade e apoio no desenvolvimento deste trabalho. À querida Marici, pela sua parceria, desde o início deste projeto científico. Obrigada por todo apoio técnico e organização de dados, bem como no auxílio na obtenção de material biológico, essenciais para o desenvolvimento deste estudo. Obrigada pelas discussões científicas e auxílio incomparável na revisão deste texto e, principalmente, pela sua amizade, nunca faltando carinho e atenção.A amiga Sandra Maria, Sandroca, por toda sua orientação, auxílio nos experimentos e discussão de citometria, que foram tão essenciais para mim! Obrigada por seu incansável apoio, por sua amizade e carinho.A Samar, sempre amiga e acolhedora. Sua amizade tem sido um privilégio para mim.Obrigada por tudo! Poder contar com pessoas tão especiais faz com que tenhamos força para buscarmos nossos objetivos e enfrentarmos as dificuldades que a vida nos apresenta.Aos amigos da equipe de endometriose, Doutores

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Expression of natural killer cell activity with CD107a on ectopic endometrium in woman with endometriosis compared with non-endometriosis

Cited by 3 publications

References 11 publications

The Role of Lymph-vascular Space Invasion towards Disease of Free Survival and Overall Survival Cancer in High-Risk Endometrial Cancer Endometrioid Type Patients

The Role of Lymph-vascular Space Invasion towards Disease of Free Survival and Overall Survival Cancer in High-Risk Endometrial Cancer Endometrioid Type Patients

Outcome and Radiotherapy Side Effects of High-Risk Endometrial Cancer

Papel de MICA na endometriose

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