Expression of neural stem cell markers in malignant rhabdoid tumor cell lines

Okuno, Kazuto; Ohta, Shigeru; Katô, Hirofumi; Taga, Takashi; Sugita, Kanji; Takeuchi, Yoshihiro

doi:10.3892/or_00000659

Cited by 9 publications

(2 citation statements)

References 48 publications

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“…Cell type may influence not only whether a mutation acts as driver, but also whether a driver gene appears to be an oncogene or a tumor suppressor (91). However, not all cancers have a known cell of origin; rhabdoid tumors, for instance, do not (92). Other mutations present in the model system used must also be considered.…”

Section: Functional Validation Of Candidate Driversmentioning

confidence: 99%

Driver and Passenger Mutations in Cancer

Pon

Marra

2015

Annu. Rev. Pathol. Mech. Dis.

305

236

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Next-generation sequencing has allowed identification of millions of somatic mutations and epigenetic changes in cancer cells. A key challenge in interpreting cancer genomes and epigenomes is distinguishing which genetic and epigenetic changes are drivers of cancer development. Frequency-based and function-based approaches have been developed to identify candidate drivers; we discuss the advantages and drawbacks of these methods as well as their latest refinements. We focus particularly on identification of the types of drivers most likely to be missed, such as genes affected by copy number alterations, mutations in noncoding regions, dysregulation of microRNA, epigenetic changes, and mutations in chromatin modifiers.

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Section: Functional Validation Of Candidate Driversmentioning

confidence: 99%

Driver and Passenger Mutations in Cancer

Pon

Marra

2015

Annu. Rev. Pathol. Mech. Dis.

305

236

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“…Several studies have reported that nestin is a marker of CSCs in different malignancies [ 63 , 64 , 65 ]. CSCs represent a distinct population of undifferentiated cells responsible for tumor initiation and maintenance, and play a prominent role in the growth, migration, and invasion of neoplasms.…”

Section: Nestin-expressing Cells In Lung Cancermentioning

confidence: 99%

Nestin-Expressing Cells in the Lung: The Bad and the Good Parts

Jaramillo‐Rangel

Chávez-Briones

Ancer-Arellano

et al. 2021

Cells

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Nestin is a member of the intermediate filament family, which is expressed in a variety of stem or progenitor cells as well as in several types of malignancies. Nestin might be involved in tissue homeostasis or repair, but its expression has also been associated with processes that lead to a poor prognosis in various types of cancer. In this article, we review the literature related to the effect of nestin expression in the lung. According to most of the reports in the literature, nestin expression in lung cancer leads to an aggressive phenotype and resistance to chemotherapy as well as radiation treatments due to the upregulation of phenomena such as cell proliferation, angiogenesis, and metastasis. Furthermore, nestin may be involved in the pathogenesis of some non-cancer-related lung diseases. On the other hand, evidence also indicates that nestin-positive cells may have a role in lung homeostasis and be capable of generating various types of lung tissues. More research is necessary to establish the true value of nestin expression as a prognostic factor and therapeutic target in lung cancer in addition to its usefulness in therapeutic approaches for pulmonary diseases.

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The RNA-Binding Protein Musashi1: A Major Player in Intestinal Epithelium Renewal and Colon Cancer Development

Plateroti

Araújo

Silva

et al. 2012

Curr Colorectal Cancer Rep

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Aberrant gene expression is the cause and the consequence of tumorigenesis. A major component of gene expression is translation regulation; a process whose main players are RNA-binding-proteins (RBPs). More than 800 RBPs have been identified in the human genome and several of them have been shown to control gene networks associated with relevant cancer processes. A more systematic characterization of RBPs starts to reveal that similar to transcription factors, they can function as tumor suppressors or oncogenes. A relevant example is Musashi1 (Msi1), which is emerging as a critical regulator of tumorigenesis in multiple cancer types, including colon cancer. Msi1 is a stem marker in several tissues and is critical in maintaining the balance between self-renewal and differentiation. However, a boost in Msi1 expression can most likely lead cells towards an oncogenic pathway. In this article, we discuss the parallels between Msi1 function in normal renewal of intestinal epithelium and in colon cancer.

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Expression of neural stem cell markers in malignant rhabdoid tumor cell lines

Cited by 9 publications

References 48 publications

Driver and Passenger Mutations in Cancer

Driver and Passenger Mutations in Cancer

Nestin-Expressing Cells in the Lung: The Bad and the Good Parts

The RNA-Binding Protein Musashi1: A Major Player in Intestinal Epithelium Renewal and Colon Cancer Development

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