Expression of NUCB2/nesfatin-1 in the taste buds of rats

Cao, Xun; Zhou, Xiao; Cao, Yang; Liu, Xiaomin; Zhou, Lihong

doi:10.1507/endocrj.ej15-0489

Cited by 4 publications

(1 citation statement)

References 33 publications

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“…Nesfatin-1, an endocrine peptide involved in appetite regulation, is a cleavage product of nuclear histone 2 (NUCB2), which contains 82 amino acids [1] . Nesfatin-1 was first found in the hypothalamus of rats by O-I et al Later studies showed that Nesfatin-1 could play a variety of roles in the central and peripheral regions.Nesfatin-1 is widely distributed in feeding-related brain regions, such as paraventricular nucleus (PVN), arcuate nucleus (ARC), ventromedial nucleus (VMH), hippocampus (Hi), amygdala, septal nucleus, brainstem, dorsal vagal nucleus, solitary tract nucleus and posterior region [2] .…”

Section: Introductionmentioning

confidence: 99%

The Nesfatin-1 Pathway from Hippocampus to Ventromedial Nucleus and its Regulation on Gastric Motility in Diabetic Rat

Jing¹,

Yang²,

Xin³

et al. 2019

ijSciences

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To investigate the effect of microinjection of Nesfatin-1 into VMH on gastric motility in diabetic rats and its regulatory mechanism, and to study whether electrical stimulation of hippocampal CA1 region can regulate this process. Methods: The diabetic rat model was established, and the hippocampal-VMH nesfatin-1 pathway was observed by retrograde gold fluorescence tracing combined with fluorescence immunohistochemistry. The effects of microinjection of nesfatin-1 by VMH and electrical stimulation of hippocampus on gastric motility were observed in vivo. Results: Nesfatin-1 inhibited gastric motility in a dose-dependent manner, and astressin-B partially blocked the inhibition of nesfatin-1 on gastric motility; Nesfatin-1 immunoreactive neurons were present in the cytoplasm of hippocampal CA1 region and Nesfatin-1 was expressed in some fluorescent gold labeled cells; electrostimulation of hippocampal CA1 region could promote gastric motility in diabetic rats, and anti-NUCB2/Nesfatin-1 antibody could promote gastric motility in diabetic rats.Enhance the effect of electrical stimulation of hippocampal CA1 region on gastric motility. Conclusion: Nesfatin-1 injection into VMH can regulate gastric motility in diabetic rats, which may be related to the CRF system, and the hippocampal CA1 region participates in the regulation of gastric motility by nesfatin-1 in VMH.

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Section: Introductionmentioning

confidence: 99%