Expression of Sox2 in human ovarian epithelial carcinoma

Ye, Feng; Li, Yanli; Hu, Ying; Zhou, Caiyun; Hu, Yuting; Chen, Huaizeng

doi:10.1007/s00432-010-0867-y

Cited by 57 publications

(52 citation statements)

References 20 publications

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“…Surprisingly, our findings are in contrast with previous evidence linking Sox2 overexpression with poor outcomes. 53,55,56 In our analysis, both the K-M and the Cox predictive models confer a significant survival advantage with Sox2 amplification. Although the exact meaning of the association between Sox2 amplification and improved outcome is unclear, such relationships are not uncommon.…”

Section: Discussionmentioning

confidence: 76%

“…12,14,15,54 Particularly, in gynecologic cancers, alterations of pathways involved in cell fate determination such as Hedgehog (Hh) and Notch were frequently observed; however, mutations in those maintaining potency (Nanog, Sox2, and Oct4) were not found as often. 13,[55][56][57][58][59] Therefore, identification of cells within the tumor capable of pluripotency and selfrenewal properties is a relevant approach that may add to our current understanding of the pathophysiology of EOC. In this work, we demonstrated the expression of Sox2, Nanog, and Oct4 (POU5F1) in EOC cell lines.…”

Section: Discussionmentioning

confidence: 99%

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Sox2 Gene Amplification Significantly Impacts Overall Survival in Serous Epithelial Ovarian Cancer

et al. 2015

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Epithelial ovarian cancer (EOC) is the deadliest gynecologic cancer. Recently, the existence of ovarian cancer stem cells has been reported. Sox2, Nanog and Oct4 are key markers of ''stemness''. The objective of this study was to determine whether Sox2, Nanog, and Oct4 are associated with EOC and poor outcome. The expression of these markers was assessed by immunofluorescence staining and real-time RT-PCR in human EOC cell lines MDAH-2774 and SKOV-3, while the cancer genome atlas (TCGA) dataset was analyzed for associations with survival. Sox2, Nanog and Oct4 (POU5F1) were all detected by immunofluorescence staining and these results were confirmed by real-time RT-PCR. The TCGA dataset revealed a 26%, 9%, and 6% amplification of Sox2, Nanog and POU5F1, respectively. Additionally, K-M survival analyses showed a significant median overall survival difference (41 versus 48.3 months, P ¼ .01) for Sox2 amplification, but not for Nanog (44.1 versus 36.2 months, P > .05) and POU5F1 (43.5 versus 45.0 months, P > .05). Our results suggest that Sox2 gene amplification significantly influences overall survival.

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Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Sox2 Gene Amplification Significantly Impacts Overall Survival in Serous Epithelial Ovarian Cancer

et al. 2015

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“…Although the phenotypical association of SOX2 with ovarian cancer as well as the association of SOX2 expression with the poor clinical outcome of ovarian cancer has been reported (Ye et al, 2011;Zhang et al, 2012), a mechanistic study was not previously conducted. For the first time, we demonstrated that SOX2 inhibited cell proliferation by reducing the percentage of cells in S phase (Fig.…”

Section: Discussionmentioning

confidence: 99%

“…However, the tumor suppressive role of SOX2 was reported in gastric cancer, in which the expression of SOX2 is frequently downregulated, and SOX2 inhibits cell growth through cell cycle arrest and apoptosis (Otsubo et al, 2011). Ye et al (2011) found that SOX2 is significantly overexpressed in ovarian cancer tissues compared with normal ovary tissues. Zhang et al (2012) found that the SOX2 expression was associated with high-grade ovarian carcinoma and tumor recurrence.…”

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confidence: 98%

SOX2 Targets Fibronectin 1 to Promote Cell Migration and Invasion in Ovarian Cancer: New Molecular Leads for Therapeutic Intervention

Lou

Han

Jin

et al. 2013

OMICS: A Journal of Integrative Biology

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Ovarian cancer ranks as the second most common tumor of the female reproductive system, with a large burden on global public health. Therefore, the identification of novel molecular targets and diagnostics is an urgent need for many women affected by this disease. To this end, the human transcription factor SOX2 is involved in a wide range of pathophysiological roles, such as the maintenance of stem cell characteristics and carcinogenesis. To date, in most studies, SOX2 has been shown to promote the development of cancer, although its inhibitory roles in cancer have also been reported. However, to the best of our knowledge, the role of SOX2, specifically in ovarian cancer cells, has not been examined in detail. In this article, we report, for the first time, that SOX2 promotes migration, invasion, and clonal formation of ovarian cancer cells. We further observed that SOX2 targeted FN1, a key gene that regulates cell migration in ovarian cancer. Our findings collectively suggest that the SOX2-FN1 axis is a key pathway in mediating the migration and invasion of ovarian cancer cells. This pathway offers crucial molecular insights and promises to develop putative candidate therapeutic interventions in women with ovarian cancer.

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“…Several evidences supported that Oct-3/4 (Pou5f1: POU domain class five transcription factor 1, 45 kDa isoform) and Sox-2 (SRY (sex determining region Y)-box 2) expressions progressively increased in malignant transformation from normal ovarian epithelium to invasive carcinoma [20,21]. Indeed, both transcription factors modulate embryonic stem (ES) cell populations by influencing growth and differentiation [22,23], and are expressed by stem cancer cells [24,25].…”

Section: Introductionmentioning

confidence: 99%

Repeated ovarian stimulation does not affect the expression level of proteins involved in cell cycle control in mouse ovaries and fallopian tubes

Luigi

Rossi

Castellucci

et al. 2014

J Assist Reprod Genet

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Purpose To understand if repeated cycles (2-4 rounds) of gonadotropin stimulation could affect intracellular localization/ content of proteins controlling cell cycle progression in mouse fallopian tubes (FT) and ovaries. Methods FT and ovaries of estrous mice (control) and of stimulated mice were analyzed to detect Oct-3/4, Sox-2, p53, β-catenin, pAKT and cyclin D1 localization/content. Spindles and chromosome alignment were analyzed in ovulated oocytes. Results After round 4, FT and ovaries of control and stimulated groups showed no differences in Oct-3/4, Sox-2 and β-catenin localization nor in Oct-3/4, Sox-2, p53, β-catenin and pAKT contents. Cyclin D1 level increased significantly in FT of treated mice. Oocytes number decreased meanwhile frequency of abnormal meiotic spindles increased with treatments. Conclusions Repetitive stimulations affected oocyte spindle morphology but did not induce changes in a set of proteins involved in cell cycle progression, usually altered in ovarian cancer. The significant increase of cyclin D1 in the FT requires further investigation.

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Expression of Sox2 in human ovarian epithelial carcinoma

Abstract: The expression level of Sox2 in human ovarian tumors was directly proportional to their degree of malignancy, implying that Sox2 overexpression may be closely related to the malignant transformation of ovarian tumors.

Cited by 57 publications

References 20 publications

Sox2 Gene Amplification Significantly Impacts Overall Survival in Serous Epithelial Ovarian Cancer

Sox2 Gene Amplification Significantly Impacts Overall Survival in Serous Epithelial Ovarian Cancer

SOX2 Targets Fibronectin 1 to Promote Cell Migration and Invasion in Ovarian Cancer: New Molecular Leads for Therapeutic Intervention

Repeated ovarian stimulation does not affect the expression level of proteins involved in cell cycle control in mouse ovaries and fallopian tubes

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