Expression of stem cell markers nanog and PSCA in gastric cancer and its significance

Zhao, Xuanzhong; Wang, Rui; Hou, Mingxing

doi:10.3892/ol.2015.3884

Cited by 19 publications

(22 citation statements)

References 43 publications

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“…Overexpression of Nanog protein was positively correlated with lymph node status, infiltration scope and differentiation stages of gastric cancer, as well as advanced clinical stages of patients58,59. Another study discovered that the expression of Nanog (Nanog1 and NanogP8) was much higher in tumor than that in para-tumor tissues, and its overall level is correlated with poor prognosis59. Interestingly, Helicobacter pylori -infected cancer cells exhibited CSC-like properties, including an increased expression level of CSC-specific surface markers, including CD44 and Lgr5, as well as Nanog, Oct4 and c-Myc, and an enhanced capacity for self-renewal59.…”

Section: The Roles Of Nanog Proteins In Miscellaneous Cancersmentioning

confidence: 94%

Section: The Roles Of Nanog Proteins In Miscellaneous Cancersmentioning

confidence: 99%

“…Another study discovered that the expression of Nanog (Nanog1 and NanogP8) was much higher in tumor than that in para-tumor tissues, and its overall level is correlated with poor prognosis59. Interestingly, Helicobacter pylori -infected cancer cells exhibited CSC-like properties, including an increased expression level of CSC-specific surface markers, including CD44 and Lgr5, as well as Nanog, Oct4 and c-Myc, and an enhanced capacity for self-renewal59. Knockdown of Nanog by RNAi in gastric cancer cell lines was shown to inhibit cell proliferation, and promote cell apoptosis and S-phase cell cycle arrest43.…”

Section: The Roles Of Nanog Proteins In Miscellaneous Cancersmentioning

confidence: 99%

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Insights into the Nanog gene: A propeller for stemness in primitive stem cells

Zhang¹,

Sui²,

Ni³

et al. 2016

Int. J. Biol. Sci.

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Self-renewal and pluripotency are two major characteristics of embryonic stem cells (ESCs) that allow ESCs to maintain stem cell population, and differentiate into multiple types of adult tissues. Nanog is the key transcription factor that controls both self-renewal and pluripotency of ESCs. Similarly, cancer stem cells (CSCs) are capable of preserving population and initiating new tumor development by self-renewal. Expression of Nanog family proteins can be increased in many types of cancer which is correlated with tumor outcomes. In this review we summarized the recent understanding of the roles and mechanisms of Nanog in ESC regulation under physiological conditions. In addition, we describe the function of Nanog family proteins in different types of cancer, and the association of Nanog with clinical outcomes. Taken together, Nanog proteins are central regulators controlling both ESCs and CSCs, and are considered as a prognostic marker in many types of cancer. These findings supported the possibility of novel therapeutic potentials of Nanog against cancers.

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Section: The Roles Of Nanog Proteins In Miscellaneous Cancersmentioning

confidence: 94%

Section: The Roles Of Nanog Proteins In Miscellaneous Cancersmentioning

confidence: 99%

Section: The Roles Of Nanog Proteins In Miscellaneous Cancersmentioning

confidence: 99%

See 1 more Smart Citation

Insights into the Nanog gene: A propeller for stemness in primitive stem cells

Zhang¹,

Sui²,

Ni³

et al. 2016

Int. J. Biol. Sci.

View full text Add to dashboard Cite

show abstract

“…23 Surprisingly, PSCA is frequently overexpressed in NSCLC, 20 although this requires confirmation. Antibody-based, PSCA-targeted therapies, as well as a peptide vaccine, have been explored for the treatment of prostate cancer.…”

Section: Introductionmentioning

confidence: 99%

PSCA and MUC1 in non-small-cell lung cancer as targets of chimeric antigen receptor T cells

et al. 2017

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“…including epithelial, mesenchymal, hematopoietic malignancies), (iii) prognostic, and (iv) mechanistic (allowing analyses of the underlying biology of the disease). Most prior reports examine whether stem cell-associated ‘factors’ are found in poorly differentiated or poor prognosis cancers [34–43]. The majority of the remaining reports extend this work to investigate if a previously derived limited number of genes expressed in stem cells (a stem cell ‘signature’), if expressed in cancers, stratifies the latter by prognosis [8, 9, 44–60].…”

Section: Discussionmentioning

confidence: 99%

Distance in cancer gene expression from stem cells predicts patient survival

Riester

Zehir

et al. 2017

PLoS ONE

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The degree of histologic cellular differentiation of a cancer has been associated with prognosis but is subjectively assessed. We hypothesized that information about tumor differentiation of individual cancers could be derived objectively from cancer gene expression data, and would allow creation of a cancer phylogenetic framework that would correlate with clinical, histologic and molecular characteristics of the cancers, as well as predict prognosis. Here we utilized mRNA expression data from 4,413 patient samples with 7 diverse cancer histologies to explore the utility of ordering samples by their distance in gene expression from that of stem cells. A differentiation baseline was obtained by including expression data of human embryonic stem cells (hESC) and human mesenchymal stem cells (hMSC) for solid tumors, and of hESC and CD34+ cells for liquid tumors. We found that the correlation distance (the degree of similarity) between the gene expression profile of a tumor sample and that of stem cells orients cancers in a clinically coherent fashion. For all histologies analyzed (including carcinomas, sarcomas, and hematologic malignancies), patients with cancers with gene expression patterns most similar to that of stem cells had poorer overall survival. We also found that the genes in all undifferentiated cancers of diverse histologies that were most differentially expressed were associated with up-regulation of specific oncogenes and down-regulation of specific tumor suppressor genes. Thus, a stem cell-oriented phylogeny of cancers allows for the derivation of a novel cancer gene expression signature found in all undifferentiated forms of diverse cancer histologies, that is competitive in predicting overall survival in cancer patients compared to previously published prediction models, and is coherent in that gene expression was associated with up-regulation of specific oncogenes and down-regulation of specific tumor suppressor genes associated with regulation of the multicellular state.

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Expression of stem cell markers nanog and PSCA in gastric cancer and its significance

Cited by 19 publications

References 43 publications

Insights into the Nanog gene: A propeller for stemness in primitive stem cells

Insights into the Nanog gene: A propeller for stemness in primitive stem cells

PSCA and MUC1 in non-small-cell lung cancer as targets of chimeric antigen receptor T cells

Distance in cancer gene expression from stem cells predicts patient survival

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