Expression of stem cell pluripotency factors during regeneration in newts

Maki, Nobuyasu; Suetsugu-Maki, Rinako; Tarui, Hiroshi; Agata, Kiyokazu; Rio‐Tsonis, Katia Del; Tsonis, Panagiotis A.

doi:10.1002/dvdy.21959

Cited by 122 publications

(107 citation statements)

References 30 publications

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“…Three of the six transcription factor genes ( klf4 , sox2 , c‐myc ) used to reprogram mammalian adult somatic cells to induced pluripotent stem cells (iPSCs) (Takahashi et al., 2007; Yu, Vodyanik et al., 2007) were found to be upregulated during blastema formation in regenerating newt limbs, and also during lens regeneration (Maki et al., 2009). The Lin 28 protein, the product of a fourth transcription factor gene used to derive iPSCs (Yu, Vodyanik et al., 2007), is also upregulated during blastema formation in regenerating axolotl limbs (Rao et al., 2009).…”

Section: Formation Of the Accumulation Blastemamentioning

confidence: 99%

Mechanisms of urodele limb regeneration

Stocum

2017

Regeneration

109

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This review explores the historical and current state of our knowledge about urodele limb regeneration. Topics discussed are (1) blastema formation by the proteolytic histolysis of limb tissues to release resident stem cells and mononucleate cells that undergo dedifferentiation, cell cycle entry and accumulation under the apical epidermal cap. (2) The origin, phenotypic memory, and positional memory of blastema cells. (3) The role played by macrophages in the early events of regeneration. (4) The role of neural and AEC factors and interaction between blastema cells in mitosis and distalization. (5) Models of pattern formation based on the results of axial reversal experiments, experiments on the regeneration of half and double half limbs, and experiments using retinoic acid to alter positional identity of blastema cells. (6) Possible mechanisms of distalization during normal and intercalary regeneration. (7) Is pattern formation is a self‐organizing property of the blastema or dictated by chemical signals from adjacent tissues? (8) What is the future for regenerating a human limb?

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Section: Formation Of the Accumulation Blastemamentioning

confidence: 99%

Mechanisms of urodele limb regeneration

Stocum

2017

Regeneration

109

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“…Three of these six genes (klf4, Sox2, c-myc), are up-regulated during blastema formation in regenerating newt limbs, and also during newt lens regeneration (Maki et al, 2009). Up-regulation of the Lin 28 protein was detected during blastema formation in regenerating axolotl limbs (Rao et al, 2009).…”

Section: Mechanisms Of Histolysismentioning

confidence: 99%

Looking proximally and distally: 100 years of limb regeneration and beyond

Stocum

Cameron

2011

Developmental Dynamics

108

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The experimental study of amphibian limb regeneration spans most of the 20 th century and the first decade of the 21 st century. We first review the major questions investigated over this time span: (1) the origin of regeneration blastema cells, the mechanism of tissue breakdown that liberates cells from their tissue organization to participate in blastema formation, (3) the mechanism of dedifferentiation of these cells, (4) how the blastema grows, (5) how the blastema is patterned to restore the missing limb structures, and (6) why adult anurans, birds and mammals do not have the regenerative powers of urodele salamanders. We then look forward in a perspective to discuss the many unanswered questions raised by investigations of the past century, what new approaches can be taken to answer them, and what the prospects are for translation of basic research on limb regeneration into clinical means to regenerate human appendages. Developmental Dynamics 240:943-968,

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“…Although the expression of progenitor cell markers has been reported in fish [51,10] and amphibians [52], unbiased in situ visualisation of the recruited cells is still required. Recruited mesenchymal cells in the stump mesenchyme re-enter into the cell cycle and migrate to the wound while still dividing.…”

Section: Purinergic Pathway Downstream Of Apoptotic Cells Is Essentiamentioning

confidence: 99%

Adenosine enhances progenitor cell recruitment and nerve growth via its A2B receptor during adult fin regeneration

Rampon

Gauron

Meda

et al. 2014

Purinergic Signalling

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A major issue in regenerative medicine is the control of progenitor cell mobilisation. Apoptosis has been reported as playing a role in cell plasticity, and it has been recently shown that apoptosis is necessary for organ and appendage regeneration. In this context, we explore its possible mode of action in progenitor cell recruitment during adult regeneration in zebrafish. Here, we show that apoptosis inhibition impairs blastema formation and nerve growth, both of which can be restored by exogenous adenosine acting through its A2B receptor. Moreover, adenosine increases the number of progenitor cells. Purinergic signalling is therefore an early and essential event in the pathway from lesion to blastema formation and provides new targets for manipulating cell plasticity in the adult.

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Expression of stem cell pluripotency factors during regeneration in newts

Cited by 122 publications

References 30 publications

Mechanisms of urodele limb regeneration

Mechanisms of urodele limb regeneration

Looking proximally and distally: 100 years of limb regeneration and beyond

Adenosine enhances progenitor cell recruitment and nerve growth via its A2B receptor during adult fin regeneration

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