Expression of Superoxide Dismutase Isoforms in Inflamed Gingiva

Na, Hei-Jin; Kim, Ok-Su; Park, Byung-Ju

doi:10.5051/jkape.2006.36.1.97

Cited by 7 publications

(7 citation statements)

References 32 publications

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“…Among the many intrinsic antioxidants, SOD is a primary defending substance that protects cells from ROS by converting O 2 - to H 2 O 2 . The SOD variants found in the human body can be divided into copper/zinc-SOD (Cu/Zn-SOD, SOD 1), manganese SOD (Mn-SOD, SOD 2) and extracellular SOD (EC-SOD, SOD 3) according to the essential metal elements for their catalytic function [ 13 , 15 ]. Many studies have examined SOD and periodontitis.…”

Section: Discussionmentioning

confidence: 99%

“…Many studies have examined SOD and periodontitis. Na et al [ 13 ] reported the expression of the SOD isoform associated with inflammatory gingival tissue. They carried out histological analysis on 33 chronic periodontitis patients and 20 periodontally healthy subjects.…”

Section: Discussionmentioning

confidence: 99%

“…They carried out histological analysis on 33 chronic periodontitis patients and 20 periodontally healthy subjects. The results indicated that the increase in SOD activity in the inflammatory periodontal tissue is associated with oxidative stimulation in periodontitis patients [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

“…Previous research focused on the immune mechanisms of the secretory immunoglobulin A and protein-enzymatic defense system [ 11 ]. Recently, research into various enzymatic salivary systems as antioxidants has clarified the importance of other defense systems in the saliva [ 10 , 12 , 13 ]. Chapple et al [ 9 ] reported that patients with periodontal diseases had a low total antioxidant status (TAS).…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant profile of whole saliva after scaling and root planing in periodontal disease

Kim

et al. 2010

J Periodontal Implant Sci

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PurposeThis study compared the total antioxidant status (TAS) and superoxide dismutase (SOD) activity in the saliva of periodontally compromised patients before and after scaling and root planing (SRP) to assess their diagnostic utility.MethodsSevere chronic periodontitis patient (test group) and subjects with no attachment loss, sites showing a 3 mm or more probing depth and a sulcus bleeding index < 10% (control group) were enrolled in this study. Saliva sampling and clinical examination were performed at one week, one month and 3 months after SRP. The TAS and SOD activity in each patient's saliva was measured for the comparative analysis between the groups.ResultsIn the test group, the TAS decreased directly after SRP. With time, it increased slightly and was relatively unchanged compared to the baseline. In the control group, the TAS also decreased immediately after SRP but increased gradually with time until 3 months. The SOD activity in the test and control subjects decreased immediately after SRP until 1 month. At 3 months, the SOD activity had increased. Both groups had a similar profile of SOD activity. However, the SOD activity of the control group was significantly higher than that of the test group at each point in time (P < 0.05).ConclusionsThere was a significant difference in the total salivary antioxidant level between the periodontitis and healthy or gingivitis (control) group during the experiment period. The total antioxidant level in the saliva was higher in the patients with severe chronic periodontitis than the healthy or gingivitis control before SRP. The SOD activity of the periodontitis patients was lower than the control at each time point. These findings conclusively reveal the possible use of saliva as a diagnostic tool for periodontal health.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Antioxidant profile of whole saliva after scaling and root planing in periodontal disease

Kim

et al. 2010

J Periodontal Implant Sci

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“…Jacoby et al in 1991, did the biochemical analysis of periodontal soft tissues cleaved from freshly extracted human teeth, the results of the study showed that the human periodontal ligament contained about twice as much SOD activity as human skin [10]. In another study it was showed that gingival SOD levels increased in inflamed gingiva of chronic periodontitis patients indicating the increased O .− 2 generation by PMNs invaded at the disease site [11] Na et al [12] concluded that Mn-SOD was markedly increased in the inflammatory gingival tissue proportional to the severity of inflammation, the authors also stated Cu/Zn SOD was also increased but not as much as Mn-SOD.…”

Section: Discussionmentioning

confidence: 99%

Effect of Non-Surgical Periodontal Therapy on Superoxide Dismutase Levels in Gingival Tissues of Chronic Periodontitis Patients: A Clinical and Spectophotometric Analysis

2013

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Abstract. BACKGROUND: Superoxide dismutase (SOD), an antioxidant acting against superoxide (oxygen radical, O .−2 ), it is released in inflammatory pathways and causes connective tissue breakdown. Increased SOD activity in inflamed gingiva may indicate increased O .− 2 radical generation by neutrophils and other inflammatory cells at the diseased site. The aim of the study was to evaluate the effects of non-surgical periodontal therapy (NSPT) on SOD levels in gingival tissues of chronic periodontitis patients. METHODS: Forty subjects: 20 periodontally healthy (Control) and 20 chronic periodontitis (Test); age range 24-55 years were recruited. Gingival tissue samples were collected by excising the inner lining of the periodontal pocket at baseline (prior to non-surgical periodontal therapy) and 2 months post therapy. In controls, tissue samples were obtained immediately after tooth extraction scheduled for orthodontic reasons. Clinical parameters included probing depth, clinical attachment level, gingival index, bleeding index, plaque index. SOD activities were assessed spectrophotometrically at baseline and 2 months post NSPT, results were analysed statistically. RESULTS: At baseline, patients with chronic periodontitis had higher mean SOD activity (2.73 ± 1.36) than the control subjects (1.12 ± 1.13) with p = 0.00003 (p < 0.05). At 2 months post NSPT median SOD level (1.00) had come close to median SOD value of control group (0.85); p = 0.99 (p > 0.05). The resolution of inflammation with successful NSPT resulted in decreased SOD levels as in control group. Clinical parameters in patients with chronic periodontitis showed a significant improvement 2 months post NSPT (p < 0.05). CONCLUSION: Non-surgical periodontal therapy significantly improves the clinical parameters and restores previously increased SOD levels to normal in chronic periodontitis patients.

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Evaluated periodontal tissues and oxidative stress in rats with neuropathic pain-like behavior

Toraman,

Özkaraca

et al. 2023

Mol Biol Rep

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Expression of Superoxide Dismutase Isoforms in Inflamed Gingiva

Cited by 7 publications

References 32 publications

Antioxidant profile of whole saliva after scaling and root planing in periodontal disease

Antioxidant profile of whole saliva after scaling and root planing in periodontal disease

Effect of Non-Surgical Periodontal Therapy on Superoxide Dismutase Levels in Gingival Tissues of Chronic Periodontitis Patients: A Clinical and Spectophotometric Analysis

Evaluated periodontal tissues and oxidative stress in rats with neuropathic pain-like behavior

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