Expression of Surface Lymphocyte Markers in Various Courses of Gastrointestinal Tumors

Олейник, Е. К.; Shibaev, M. I.; Олейник, Виктор Михайлович

doi:10.1023/b:bebm.0000035138.57168.d2

Cited by 1 publication

(1 citation statement)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many tumors express CD98hc, and its expression correlates with poor prognosis in B cell lymphomas (Holte et al, 1987;Holte et al, 1989;Salter et al, 1989). Furthermore, nearly all studies that have examined the expression of CD98hc or CD98 light chains in solid tumors show that their expression is correlated with progressive or metastatic tumors (Esteban et al, 1990;Kaira et al, 2009a;Kaira et al, 2009b;Kaira et al, 2009c;Kaira et al, 2008;Kaira et al, 2009d;Kobayashi et al, 2008;Nawashiro et al, 2002;Nawashiro et al, 2006;Oleinik et al, 2005;Powlesland et al, 2009;Shennan et al, 2003;Xiao et al, 2005).…”

Section: Cd98 Expression In Tumorsmentioning

confidence: 99%

CD98 at the crossroads of adaptive immunity and cancer

Cantor

Ginsberg

2012

Journal of Cell Science

163

179

View full text Add to dashboard Cite

SummaryAdaptive immunity, a vertebrate specialization, adds memory and exquisite specificity to the basic innate immune responses present in invertebrates while conserving metabolic resources. In adaptive immunity, antigenic challenge requires extremely rapid proliferation of rare antigen-specific lymphocytes to produce large, clonally expanded effector populations that neutralize pathogens. Rapid proliferation and resulting clonal expansion are dependent on CD98, a protein whose well-conserved orthologs appear restricted to vertebrates. Thus, CD98 supports lymphocyte clonal expansion to enable protective adaptive immunity, an advantage that could account for the presence of CD98 in vertebrates. CD98 supports lymphocyte clonal expansion by amplifying integrin signals that enable proliferation and prevent apoptosis. These integrin-dependent signals can also provoke cancer development and invasion, anchorage-independence and the rapid proliferation of tumor cells. CD98 is highly expressed in many cancers and contributes to formation of tumors in experimental models. Strikingly, vertebrates, which possess highly conserved CD98 proteins, CD98-binding integrins and adaptive immunity, also display propensity towards invasive and metastatic tumors. In this Commentary, we review the roles of CD98 in lymphocyte biology and cancer. We suggest that the CD98 amplification of integrin signaling in adaptive immunity provides survival benefits to vertebrates, which, in turn, bear the price of increased susceptibility to cancer.

show abstract