Expression of the ErbA-beta class of thyroid hormone receptors is selectively lost in human colon carcinoma.

Markowitz, Sanford D.; Haut, Mitchell; Stellato, Thomas A.; Gerbic, Catherine; Molkentin, Kay F.

doi:10.1172/jci114349

Cited by 45 publications

(27 citation statements)

References 30 publications

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“…To our knowledge this is the ®rst description of the expression of altered TR genes in human breast cancer. Abnormalities in TR genes have been described in other human malignancies such as hepatocellular carcinomas, colon, thyroid, lung, pituitary and gastrointestinal tumors (Arbuthnot et al, 1989;Lin et al, 1999;McCabe et al, 1999;Markowitz et al, 1989;Wallin et al, 1992;Dobrovic et al, 1988). However, none of these studies included a systematic analysis of TRs expression in a substantial number of patients.…”

Section: Discussionmentioning

confidence: 99%

Expression of thyroid hormone receptor/erbA genes is altered in human breast cancer

et al. 2002

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The relation between thyroid status and diseases and cancer is unclear. No detailed analysis of thyroid hormone receptor (TR) expression in human breast cancer has been reported. We have analysed the expression and mutational status of the TRa1, encoded by the c-erbA proto-oncogene, TRb1 and TRb2 isoforms in 70 sporadic breast cancers. Alterations in the RNA level of TRb1, TRa1, or both were found in a number of patients. No expression of TRb2 RNA was detected. Western blotting analysis con®rmed the di erences in expression at the protein level in those cases where su cient tumor sample was available. Additionally, tumor-speci®c truncated TRb1 RNA was found in six patients. Strikingly, three transcripts shared the same breakpoint. Only one tumor carried the corresponding deletion at the genomic DNA level, suggesting that the remaining abnormal TRb1 transcripts are aberrant splicing products. Though no signi®cant correlation was found between TRb1 alteration and any clinical parameter, it showed a tendency to associate with early age of onset (550 years). Our results reveal speci®c alterations in the expression of TRb and TRa genes in a subset of breast cancer patients, suggesting that deregulation of thyroid hormone target genes may be involved in the generation of this neoplasia.

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Section: Discussionmentioning

confidence: 99%

Expression of thyroid hormone receptor/erbA genes is altered in human breast cancer

et al. 2002

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“…In a study using Northern blot analysis, Markowitz et al (23) reported selective loss of c-erbAP expression in human colon carcinomas. This was attributed to suppression of gene transcription since no evidence of c-erbAg gene deletion was found.…”

Section: Discussionmentioning

confidence: 99%

The C-ErbAβ Thyroid Hormone Receptor Expression and cDNA sequence analysis of the hormone-binding domain in human cancer cell lines

Chow¹,

Lim²,

Tock³

1994

Acta Oncologica

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“…Adenomas were obtained from colectomy specimens and divided into sections for histopathologic analyses and RNA extraction using our previously described methods (21). Morphologically normal colonic epithelium was obtained from colectomy specimens by blunt dissection of the mucosa off the muscularis mucosae as previously described (21).…”

Section: Methodsmentioning

confidence: 99%

Growth stimulation by coexpression of transforming growth factor-alpha and epidermal growth factor-receptor in normal and adenomatous human colon epithelium.

Markowitz¹,

Molkentin²,

Gerbic³

et al. 1990

J. Clin. Invest.

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129

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Expression of the ErbA-beta class of thyroid hormone receptors is selectively lost in human colon carcinoma.

Cited by 45 publications

References 30 publications

Expression of thyroid hormone receptor/erbA genes is altered in human breast cancer

Expression of thyroid hormone receptor/erbA genes is altered in human breast cancer

The C-ErbAβ Thyroid Hormone Receptor Expression and cDNA sequence analysis of the hormone-binding domain in human cancer cell lines

Growth stimulation by coexpression of transforming growth factor-alpha and epidermal growth factor-receptor in normal and adenomatous human colon epithelium.

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