Expression of αvβ3 integrin is less frequent in ovarian epithelial tumors of low malignant potential in contrast to ovarian carcinomas

Liapis, Helen; Adler, Lisa M.; Wick, Mark R.; Rader, Janet S.

doi:10.1016/s0046-8177(97)90033-2

Cited by 95 publications

(64 citation statements)

References 14 publications

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“…With regard to the expression and distribution of ␣v␤3 and ␣v␤5 integrins in ovarian cancer, little information is actually available. 15,35 The present investigations reveal that an absolute absence of CAR seems to be rare in ovarian cancer and occurred only in one undifferentiated carcinoma in our set of 37 investigated specimens. However, 61% of the studied specimens showed a focal pattern of heterogeneity with regard to negative and positive intratumoral regions, namely one found to be the most pronounced in grade 3 tumors or those classified as undifferentiated.…”

Section: Discussionsupporting

confidence: 47%

Determination of molecules regulating gene delivery using adenoviral vectors in ovarian carcinomas

Müller‐Holzner

Schuler

et al. 2002

Gene Ther

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Section: Discussionsupporting

confidence: 47%

Determination of molecules regulating gene delivery using adenoviral vectors in ovarian carcinomas

Müller‐Holzner

Schuler

et al. 2002

Gene Ther

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“…However, the difference, in our opinion, was insignificant. We recently demonstrated abundant ␤ 3 mRNA by in situ hybridization in T545-positive osteoclasts of breast cancer metastases to bone (Liapis et al 1996).…”

Section: Resultsmentioning

confidence: 97%

Detection of Integrins in Formalin-fixed, Paraffin-embedded Tissues

Liapis

Hutton

1997

J Histochem Cytochem.

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SUMMARYIntegrins are heterodimeric transmembrane receptors, which are expressed in many cells. In vitro experiments have demonstrated that integrins may be important in tumor progression and organ development. The functions of integrins were previously studied in cell cultures and their tissue expression was detected by immunofluorescence or immunoperoxidase in frozen sections. The purpose of this study was to determine the optimal conditions for detection of integrins in formalin-fixed, paraffin-embedded tissues. We utilized microwave heating and enzyme digestion in routinely processed, surgically removed tissues. Our results demonstrate that integrins can be reliably detected in archival material. This approach will facilitate further investigation of the role played by integrins in human malignancies and in developmental processes.

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“…Furthermore, some studies have shown that, in malignant melanoma, ovarian, breast and prostate cancer, the invasive ability of tumor cells with positive integrin β3 expression is powerful, which suggests that integrin β3 is closely related to cancer invasion and metastasis [16][17][18] . Our study showed that integrin β3 mRNA expression in gastric carcinoma samples was stronger than that in non-tumor gastric mucosa, and the positive expression rate were significantly higher in the infiltrating type group, poor differentiation, perforating serosa layer, lymphoid node invasion, hepatic metastasis and peritoneal dissemination.…”

Section: Terminologymentioning

confidence: 99%

Correlation of integrin β3 mRNA and vascular endothelial growth factor protein expression profiles with the clinicopathological features and prognosis of gastric carcinoma

Li¹,

Ye²,

Zhao³

et al. 2008

WJG

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peritoneal metastasis, the mean MVD were significantly higher than those in patients of expanding type (P < 0.01), stage T1-T2 (P < 0.01), non-vessel invasion (P < 0.01), without lymphatic metastasis (P < 0.01), without hepatic and peritoneal metastasis (P < 0.01), respectively. It was found that the positive expression rate of integrin β3 mRNA was positively related to that of VEGF protein (P < 0.01) and MVD (P < 0.05), meanwhile the positive expression rate of VEGF protein was positively related to MVD (P < 0.05). The mean survival period in patients with positive expression of integrin β3 mRNA and VEGF, and MVD ≥ 54.9/mm 2 was significantly shorter than that in patients with negative expression of integrin β3 mRNA (P < 0.05) and VEGF (P < 0.01), and MVD < 54.9/mm 2 (P < 0.01). Five-year survival rate in patients with positive expression of integrin β3 mRNA and VEGF, and MVD ≥ 54.9/mm 2 was significantly lower than those with negative expression of integrin β3 mRNA (P < 0.05), VEGF (P < 0.05), and MVD < 54.9/mm 2 (P < 0.01). CONCLUSION:Integrin β3 and VEGF expression can synergistically enhance tumor angiogenesis, and may play a crucial role in invasion and metastasis of gastric carcinoma. Therefore, they may be prognostic biomarkers and novel molecular therapeutic targets. INTRODUCTIONGastric cancer is the leading cause of death in China. Abstract AIM: To investigate integrin β3 mRNA and vascular endothelial growth factor (VEGF) protein expression in gastric carcinoma, and its correlation with microvascular density, growth-pattern, invasion, metastasis and prognosis. METHODS: In situ hybridization (ISH) of integrin β3mRNA and immunohistochemistry of VEGF and CD34 protein were performed on samples from 118 patients with gastric cancer. RESULTS:The positive rate of integrin β3 mRNA in nontumor gastric mucosa (20%) was significantly lower than that of the gastric cancer tissue (52.5%, χ 2 = 10.20,

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Expression of αvβ3 integrin is less frequent in ovarian epithelial tumors of low malignant potential in contrast to ovarian carcinomas

Cited by 95 publications

References 14 publications

Determination of molecules regulating gene delivery using adenoviral vectors in ovarian carcinomas

Determination of molecules regulating gene delivery using adenoviral vectors in ovarian carcinomas

Detection of Integrins in Formalin-fixed, Paraffin-embedded Tissues

Correlation of integrin β3 mRNA and vascular endothelial growth factor protein expression profiles with the clinicopathological features and prognosis of gastric carcinoma

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