Expression pattern of foxl2 and dmrt1 in gonad of Amur sturgeon Acipenser schrenckii in relation to sex differentiation

Okada, Hatsumi; Hagihara, Seishi; Yamashita, Katsumasa; Ijiri, Shigeho; Adachi, Souichi

doi:10.1016/j.aquaculture.2017.07.020

Cited by 24 publications

(19 citation statements)

References 43 publications

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“…foxl2 , the hallmark of granulosa cell, is one of earliest sexually dimorphic genes during ovarian development ( Bertho et al, 2016 ; Okada et al, 2017 ), which plays a pivotal role in estradiol production through the endocrine system along brain-pituitary-gonad axis ( Sridevi et al, 2012 ; Georges et al, 2014 ; Liu et al, 2019 ). Loss of foxl2 results in dysregulation of estradiol and somatic cell reprogramming ( Uhlenhaut et al, 2009 ) and even ovary-to-testis sex reversal ( Li et al, 2013 ; Yang et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Gonadal Transcriptome Analysis of Sex-Related Genes in the Protandrous Yellowfin Seabream (Acanthopagrus latus)

Lin

Fang

et al. 2020

Front. Genet.

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Yellowfin seabream (Acanthopagrus latus), a protandrous hermaphroditic fish, is a good model for studying the mechanism of sex reversal. However, limited knowledge is known about the genetic information related to reproduction and sex differentiation in this species. Here, we performed de novo transcriptome sequencing analysis of the testis, ovotestis, and ovary to identify sex-related genes in yellowfin seabream. The results assembled 71,765 unigenes in which 16,126 and 17,560 unigenes were differentially expressed in the ovotestis and ovary compared to the testis, respectively. The most differentially expressed gene (DEG)-enriched Kyoto Encyclopedia of Genes and Genomes and GO pathways were closely associated with the synthesis of sex steroid hormones. Functional analyses identified 55 important sex-related DEGs, including 32 testis-biased DEGs (dmrt1, amh, and sox9, etc.), 20 ovary-biased DEGs (cyp19a, foxl2, and wnt4, etc.), and 3 ovotestis-biased DEGs (lhb, dmrt2, and foxh1). Furthermore, the testis-specific expression of dmrt1 and the brain-pituitary-ovary axis expression of foxl2 were characterized, suggesting that they might play important roles in sex differentiation in yellowfin seabream. Our present work provided an important molecular basis for elucidating the mechanisms underlying sexual transition and reproductional regulation in yellowfin seabream.

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Section: Discussionmentioning

confidence: 99%

Gonadal Transcriptome Analysis of Sex-Related Genes in the Protandrous Yellowfin Seabream (Acanthopagrus latus)

Lin

Fang

et al. 2020

Front. Genet.

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“…For the 21 month‐old immature individuals we have observed that the gonads present the expression of all the genes investigated (Supporting Information Table S1). Similar studies have reported the expression of foxl2 , cyp17a1 , ar , dmrt1 , sox9 , star in other sturgeon species (Amberg et al ., ; Berbejillo et al ., , , ; Fajkowska et al ., ; Hagihara et al ., ; Kusakabe et al ., ; Leng et al ., ; Okada et al ., ; Wang et al ., ; Yarmohammadi et al ., ). In case of the dmrt1 gene we have observed no statistically significant difference in the expression between male and female gonads, but expression was limited to gonads.…”

Section: Comparison Of Mean (± Sd) Biological Indices Of Male and Femmentioning

confidence: 99%

Gene expression involved in the sexual development of Best Beluga hybrid sturgeons

Burcea

Popa

Florescu

et al. 2018

Journal of Fish Biology

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The scope of this study is to investigate the expression of dmrt1, foxl2, ar, star and sox9 genes in the context of the gonad development stage of 21 month‐old Best Beluga individuals. No significant difference was observed between males and females but the cyp17a1 gene showed higher expression in male than in female gonads. The results suggest that during sampling the females were in perinucleolar stage and the males in early spermatogenesis stage which led to specific patterns of expression for the investigated genes.

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“…Moreover, the expression level of dmrt1 mRNA in testis was higher than the ovary (Figure ). Similarly, Okada, Hagihara, Yamashita, Ijiri, and Adachi () also reported that the dmrt1 was predominantly expressed in the testis tissue. Accordingly, no obvious sign of dmrt1 mRNA revealed by in situ hybridization was detected in the ovary (Figure ).…”

mentioning

confidence: 73%

Molecular cloning and expression analysis of the dmrt1 gene from discus fish ( Symphysodon aequifasciatus )

et al. 2019

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Expression pattern of foxl2 and dmrt1 in gonad of Amur sturgeon Acipenser schrenckii in relation to sex differentiation

Cited by 24 publications

References 43 publications

Gonadal Transcriptome Analysis of Sex-Related Genes in the Protandrous Yellowfin Seabream (Acanthopagrus latus)

Gonadal Transcriptome Analysis of Sex-Related Genes in the Protandrous Yellowfin Seabream (Acanthopagrus latus)

Gene expression involved in the sexual development of Best Beluga hybrid sturgeons

Molecular cloning and expression analysis of the dmrt1 gene from discus fish ( Symphysodon aequifasciatus )

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