Expression pattern of lncRNAs in pituitary adenomas

Ghafouri‐Fard, Soudeh; Khaledabadi, Maryam; Najafi, Gholamreza; Safarzadeh, Arash; Hussen, Bashdar Mahmud; Eslami, Solat; Sharifi, Guive; Taheri, Mohammad; Dilmaghani, Nader Akbari

doi:10.1016/j.prp.2023.154668

Cited by 2 publications

(1 citation statement)

References 20 publications

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“… 6 In the pathobiology of cancer, thousands of intracellular factors are altered, including signalling pathways, energy metabolism, gene transcription regulators, etc. 7 , 8 , 9 , 10 Signalling pathways are often stimulated by signalling molecules found on cell membranes or within the cytoplasm, such as growth factors, hormones, or ions. For signal transduction, a variety of intracellular chemicals known as secondary messengers are used, an important one of which is cyclic adenosine monophosphate (cAMP).…”

Section: Introductionmentioning

confidence: 99%

Expression of cAMP and oxidative phosphorylation‐related lncRNAs in non‐functioning pituitary adenomas

Taheri,

Nicknam,

Bagan

et al. 2023

J Cellular Molecular Medi

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Non‐functioning pituitary adenomas (NFPAs) are benign lesions in the pituitary gland with important morbidities. In this study, based on a bioinformatics analysis to identify the genes and pathways that display significant differences between tumour tissues of NFPA patients and normal pituitary tissues, we selected lncRNAs related to cAMP and oxidative phosphorylation pathways, namely DNAH17‐AS1, LINC00706 and SLC25A5‐AS1. Then, we aimed to investigate by means of RT‐qPCR, the expression of these lncRNAs along with two other lncRNAs, namely CADM3‐AS1 and MIR7‐3HG in NFPA samples compared to that in healthy tissues adjacent to the tumours. Transcripts of DNAH17‐AS1, LINC00706 and MIR7‐3HG were lower in NFPA samples compared with controls (Expression ratios (95% CI) = 0.43 (0.23–0.78), 0.58 (0.35–0.96) and 0.58 (0.35–0.96); p‐values = 0.009, 0.025 and 0.036, respectively). AUC values of ROC curves of DNAH17‐AS1, LINC00706 and MIR7‐3HG were 0.62, 0.61 and 0.62, respectively. Expression of CADM3‐AS1 was associated with the gender of patients in a way that it was lower in female patients (p‐value = 0.04). The level of SLC25A5‐AS1 was lower in subjects with disease duration lower than 1 year (p‐value = 0.048). We showed dysregulation of three lncRNAs in NFPA tissues and potentiates these lncRNAs as important regulators of pathogenic events in these tumours.

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