Expression profiling of adrenocortical neoplasms suggests a molecular signature of malignancy

Meta-analysis of adrenocortical tumour genomics data: novel pathogenic pathways revealed

“…We found decreased ALDH1A1 and ALDH1A3 mRNA expression in ACC relative to ACA in several microarray studies (Giordano et al, 2003(Giordano et al, , 2009Vela´zquez-Ferna´ndez et al, 2005;Laurell et al, 2009;Soon et al, 2009;de Reynie`s et al, 2009). Decreased ALDH1A1 has been validated by QRT-PCR in two studies (Fernandez-Ranvier et al, 2008b;Laurell et al, 2009).…”

Prohibitin-2 Binding Modulates Insulin-like Growth Factor-binding Protein-6 (IGFBP-6)-induced Rhabdomyosarcoma Cell Migration

“…For example, MNU-induced glial carcinogenesis in the rat is associated with increased IGFBP-6 expression (30). IGFBP-6 levels are increased in pancreatic (31) and adrenocortical cancer (32), and IGFBP-6 levels correlate with meningioma invasiveness in vivo (33). These examples may represent a compensatory response to increased IGF-II activity, or they may reflect IGF-independent actions of IGFBP-6.…”

Immunohistochemical Validation of Overexpressed Genes Identified by Global Expression Microarrays in Adrenocortical Carcinoma Reveals Potential Predictive and Prognostic Biomarkers

“…Significant advances in our understanding of the molecular aspects of the disease have arisen from identification of genetic changes in rare familial syndromes manifesting ACC and comparison to sporadic ACC and use of genomewide messenger RNA (mRNA) and micro-RNA (miRNA) expression studies and comparative genomic hybridization and methylation profiling studies [6][7][8][9][10][11]. In a similar fashion, genomewide gene expression profiling has identified several dysregulated genes associated with ACC [12][13][14][15][16] and has been able to stratify outcomes depending on the grade of ACC [12,17].…”