Expression profiling of B cell chronic lymphocytic leukemia suggests deficient CD1-mediated immunity, polarized cytokine response, altered adhesion and increased intracellular protein transport and processing of leukemic cells

Zhang, Zheng; Venkatapathy, Sumathi; Rao, Geetha; Harrington, CA

doi:10.1038/sj.leu.2402711

Cited by 56 publications

(45 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…47 Several septins have altered expression in lymphoid, breast, skin, ovary, endometrium, kidney, lung, liver, brain, pancreas, colorectal and urological tumors. 47,51,52 Involvement of the cytoskeleton is further underlined by the fact that DMD was found in most previous CLL microarray studies 1,3,4,53 and proved to be of prognostic value in our patients.…”

Section: Clinical Valuementioning

confidence: 94%

Deregulated expression of fat and muscle genes in B-cell chronic lymphocytic leukemia with high lipoprotein lipase expression

et al. 2006

View full text Add to dashboard Cite

Section: Clinical Valuementioning

confidence: 94%

Deregulated expression of fat and muscle genes in B-cell chronic lymphocytic leukemia with high lipoprotein lipase expression

et al. 2006

View full text Add to dashboard Cite

“…46 On the other hand, B-CLL patients have been observed to develop autoimmune diseases, frequently, implying immune dysregulation. 47 It has been postulated that the association of certain autoimmune diseases with B-CLL reflects reverse causality due to undetected cases of CLL manifesting in patients who express autoimmune disorders as their first symptom. This hypothesis is based on the rationale that during the course of B-CLL, some degree of activation of B cells may lead to an autoimmune disorder in CLL.…”

mentioning

confidence: 99%

Diabetes and the risk of non-Hodgkin's lymphoma and multiple myeloma in the European Prospective Investigation into Cancer and Nutrition

Khan¹,

Gallo²,

Linseisen³

et al. 2008

Haematologica

View full text Add to dashboard Cite

BackgroundNon-Hodgkin's lymphomas are a heterogeneous group of neoplasms arising from the lymphopoietic system including a wide range of subtypes of either B-cell or T-cell lymphomas. The few established risk factors for the development of these neoplasms include viral infections and immunological abnormalities, but their etiology remains largely unknown. Evidence suggests that certain medical conditions may be linked, through immunosuppression, to the risk of nonHodgkin's lymphoma. Multiple myeloma is a neoplasm of plasma cells that accounts for approximately 15% of lymphopoietic cancers. Increases in the incidence of non-Hodgkin's lymphoma and multiple myeloma in the past implicate environmental factors as potential causal agents.

show abstract

“…This is in agreement with a recent report using oligonucleotide microarrays, demonstrating a five-fold increased expression of the IL-4 receptor in CLL B-cells when compared to normal tonsilar CD5 þ B cells. 42 On the other hand, a potent increase of IL-4 levels in T cells from CLL patients was also reported. 43,44 Thus, iNOS mRNA variants induced by IL-4 signaling pathway could play a role in the survival advantage displayed by leukemic B-CLL cells.…”

Section: Discussionmentioning

confidence: 99%

Post-transcriptional regulation of inducible nitric oxide synthase in chronic lymphocytic leukemia B cells in pro- and antiapoptotic culture conditions

et al. 2003

View full text Add to dashboard Cite

Functional inducible NOS (iNOS) may be involved in the prolonged lifespan of chronic lymphocytic leukemia cells (B-CLL), although the exact mechanisms implicated remain elusive as yet. In this work, we have examined iNOS expression in normal B lymphocytes and B-CLL cells in pro-and antiapoptotic conditions. Our results demonstrate: (1) The existence of a new splice variant characterized by a complete deletion of exon 14 (iNOS 13-16 14del ), which was preferentially detected in normal B lymphocytes and may represent an isoform that could play a role in the regulation of enzyme activity. (2) The existence of another alternatively spliced iNOS mRNA transcript involving a partial deletion of the flavodoxin region (iNOS 13-16 neg ) was correlated to a decreased B-CLL cell viability. The 9-b-D-arabinofuranosyl-2-fluoradenine or fludarabine (F-ara) treatment induced iNOS 13-16 neg transcript variants, whereas IL-4 enhanced both the transcription of variants, including these exons (iNOS 13-16 pos ), and the expression of a 122 kDa iNOS protein. These results suggest that in B-CLL, a regulation process involving nitric oxide ( K NO) levels could occur by a post-transcriptional mechanism mediated by soluble factors. Our results also provide an insight into a new complementary proapoptotic action of F-ara in B-CLL by the induction of particular iNOS splice variants, leading to the activation of a caspase-3-dependent apoptotic pathway.

show abstract

Expression profiling of B cell chronic lymphocytic leukemia suggests deficient CD1-mediated immunity, polarized cytokine response, altered adhesion and increased intracellular protein transport and processing of leukemic cells

Cited by 56 publications

References 54 publications

Deregulated expression of fat and muscle genes in B-cell chronic lymphocytic leukemia with high lipoprotein lipase expression

Deregulated expression of fat and muscle genes in B-cell chronic lymphocytic leukemia with high lipoprotein lipase expression

Diabetes and the risk of non-Hodgkin's lymphoma and multiple myeloma in the European Prospective Investigation into Cancer and Nutrition

Post-transcriptional regulation of inducible nitric oxide synthase in chronic lymphocytic leukemia B cells in pro- and antiapoptotic culture conditions

Contact Info

Product

Resources

About