Extended intraoperative peritoneal lavage as prophylactic peritoneal recurrence for locally advanced gastric cancer: a prospective randomized trial

Rodriguez-Santiago, Joaquín; Luna, A. Bayés de; Garsot, Elisenda; Aldeano, Aurora; Balagué, C.; Rada, Aishling M.

doi:10.1007/s12094-021-02596-8

Cited by 6 publications

(10 citation statements)

References 20 publications

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“…A total of five studies ( 16 – 20 ) with 1,790 patients were included in the current meta-analysis. The publication year was from 2009 to 2021.…”

Section: Resultsmentioning

confidence: 99%

“…Previous studies reported that EIPL could prolong OS and reduce complications (16,17). However, other studies have shown that EIPL does not bring significant survival benefits and complications (18)(19)(20). Therefore, it is necessary to analyze the exact efficacy of EIPL.…”

Section: Discussionmentioning

confidence: 99%

“…Data regarding overall postoperative complications were extracted from four studies (16,(18)(19)(20). After pooling up the data, no significant difference was found between EIPL group and No EIPL group (OR = 0.88, 95% CI = 0.51 to 1.53, P = 0.65) (Figure 3A).…”

Section: Comparison Of Complications Between Eipl Group and No Eipl Groupmentioning

confidence: 99%

“…There were four studies reporting OS (17)(18)(19)(20) and two studies reporting DFS and PRFS (18,19). After pooling up all the data, no significant difference was found between EIPL group and No EIPL group in terms of OS (HR = 0.77, 95% CI = 0.36 to 1.64, P = 0.49) (Figure 4A), DFS (HR = 0.97, 95% CI = 0.71 to 1.33, P = 0.87) (Figure 5A), and PRFS (HR = 1.03, 95% CI = 0.74 to 1.43, P = 0.86) (Figure 5B).…”

Section: Survival Analysis Between Eipl Group and No Eipl Groupmentioning

confidence: 99%

“…Previous studies have reported that EIPL could prolong overall survival and reduce complications (16,17). However, other studies have shown that EIPL does not bring significant survival benefits and complications (18)(19)(20). Therefore, the purpose of the current meta-analysis is to analyze whether EIPL can bring benefit on short-term outcomes or survival.…”

Section: Introductionmentioning

confidence: 99%

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Does Extended Intraoperative Peritoneal Lavage Really Bring Benefit on Patients With Gastric Cancer? A Meta-Analysis of Published Clinical Trials

et al. 2021

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PurposeThe purpose of the current meta-analysis is to analyze whether extended intraoperative peritoneal lavage (EIPL) can bring benefit on short-term outcomes or survival for patients undergoing curative gastrectomy for gastric cancer.MethodsThe PubMed, Embase, and Cochrane Library databases were searched from inception to May 3, 2021, to find eligible studies. Postoperative complications, overall survival (OS), disease-free survival (DFS), and peritoneal recurrence–free survival (PRFS) were compared between EIPL group and No EIPL group.ResultsA total of five randomized controlled trials with 1,790 patients were included in the current meta-analysis. No difference was found in baseline information (p > 0.05). After pooling up the data of overall postoperative complications, no significant difference was found between EIPL group and No EIPL group (OR = 0.88, 95% CI = 0.51 to 1.53, P = 0.65). Furthermore, there was no significant difference between EIPL group and No EIPL group in terms of OS (HR = 0.77, 95% CI = 0.36 to 1.64, P = 0.49), DFS (HR = 0.97, 95% CI = 0.71 to 1.33, P = 0.87), and PRFS (HR = 1.03, 95% CI = 0.74 to 1.43, P = 0.86). In terms of subgroup analysis of OS, no significant difference was found as well (HR = 1.05, 95% CI = 0.82 to 1.34, P = 0.69).ConclusionsEIPL did not bring benefit in terms of short-term outcomes or survival. Therefore, EIPL is not recommended for patients undergoing curative gastrectomy for gastric cancer.

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“…A total of five studies ( 16 – 20 ) with 1,790 patients were included in the current meta-analysis. The publication year was from 2009 to 2021.…”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Comparison Of Complications Between Eipl Group and No Eipl Groupmentioning

confidence: 99%

Section: Survival Analysis Between Eipl Group and No Eipl Groupmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Does Extended Intraoperative Peritoneal Lavage Really Bring Benefit on Patients With Gastric Cancer? A Meta-Analysis of Published Clinical Trials

et al. 2021

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Efficacy and Safety of Extensive Intraperitoneal Lavage for Patients with Gastric Cancer — A Systematic Review and Meta-analysis

Najah,

Abdelrehim,

Elmallahy

et al. 2023

J Gastrointest Canc

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Extensive intraoperative peritoneal lavage with surgery, compared to surgery alone, for patients diagnosed with gastric cancer: a systematic review and meta-analysis of randomized controlled trials

Adil,

Ghori,

Anwar

et al. 2024

International Journal of Surgery

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Background: Gastric cancer ranks as the fifth most frequently diagnosed cancer and the seventh most prevalent overall. The lifetime risk of developing gastric cancer is 1.87% for males and 0.79% for females worldwide. Aim: This systematic review and meta-analysis aimed to determine whether Extensive Intraoperative Peritoneal Lavage (EIPL) provides short-term benefits or improved survival outcomes for patients undergoing gastrectomy. Methods: A comprehensive search spanned PubMed, Embase, Cochrane Library, clinicaltrials.gov, and Web of Science, from their inception up to October 2023, adhering to predefined inclusion and exclusion criteria. The quality of the studies was analyzed using the Cochrane Collaboration Risk of Bias Tool. Data analysis was done using Review Manager 5.3, utilizing a random-effects model. Results: Our analysis incorporated seven randomized controlled trials with 2602 patients. The follow-up time for all outcomes varied from 30-60 months. For our primary outcomes, EIPL demonstrated a significant benefit over surgery alone in terms of recurrence (RR=0.73; 95% CI: 0.65 to 0.83, P<0.00001) and postoperative complications (RR=0.67; 95% CI: 0.51 to 0.87, P=0.003). For our secondary outcomes, postoperative hospital stay (MD=-0.35; 95% CI: −1.11 to 0.41; P-value=0.37), 3-year overall survival (OR=1.44; 95% CI 0.84 to 2.47; P-value=0.19), 3-year disease-free survival (HR=0.93; 95% CI: 0.78 to 1.13; P-value=0.48), and time to first flatus (MD=-0.17; 95% CI: −0.35 to 0.01; P-value=0.06), no statistically significant differences were observed between the EIPL and control groups. Conclusion: While there is a marginal difference in survival outcomes, EIPL holds promise in significantly reducing overall cancer recurrence and suggests an enhancement in postoperative recovery.

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Extended intraoperative peritoneal lavage as prophylactic peritoneal recurrence for locally advanced gastric cancer: a prospective randomized trial

Cited by 6 publications

References 20 publications

Does Extended Intraoperative Peritoneal Lavage Really Bring Benefit on Patients With Gastric Cancer? A Meta-Analysis of Published Clinical Trials

Does Extended Intraoperative Peritoneal Lavage Really Bring Benefit on Patients With Gastric Cancer? A Meta-Analysis of Published Clinical Trials

Efficacy and Safety of Extensive Intraperitoneal Lavage for Patients with Gastric Cancer — A Systematic Review and Meta-analysis

Extensive intraoperative peritoneal lavage with surgery, compared to surgery alone, for patients diagnosed with gastric cancer: a systematic review and meta-analysis of randomized controlled trials

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