Extended Multiple-Field High-Definition transcranial direct current stimulation (HD-tDCS) is well tolerated and safe in healthy adults

Turski, C; Kessler-Jones, Alanna; Chow, Clara K; Hermann, Bruce P.; Hsu, David T.; Jones, Jana E.; Seeger, Susanne; Chappell, Rick; Boly, Mélanie; Ikonomidou, Chrysanthy

doi:10.3233/rnn-170757

Cited by 26 publications

(24 citation statements)

References 66 publications

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“…Second, the amount of electrical stimulation that reaches the targeted area is a critical factor in inducing clinical effects. Computational models to estimate cortical electric fields [52] and high-definition tDCS [53] are tools that may help us design more focused tDCS montages. Third, the tDCS dosage could be insufficient in our study.…”

Section: Discussionmentioning

confidence: 99%

Transcranial direct current stimulation in patients with obsessive compulsive disorder: A randomized controlled trial

et al. 2019

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Background: Obsessive-compulsive disorder (OCD) is a severe mental disorder with poor response to the available treatments. Neuroimaging studies have identified dysfunctions within the orbito-fronto-striato-pallido-thalamic network in patients with OCD. Here, we assessed the efficacy and safety of transcranial direct current stimulation (tDCS) applied with the cathode over the orbitofrontal cortex (OFC) and the anode over the right cerebellum to decrease OCD symptoms in patients with treatment-resistant OCD. Methods: In a randomized sham-controlled double-blind study, 21 patients with OCD were assigned to receive ten 20-min sessions (two sessions per day) of either active (2 mA) or sham tDCS. The clinical symptoms were measured using the Yale-Brown Obsessive and Compulsive Scale (YBOCS). Acute effects on the symptoms were measured from baseline to immediately after the 10 tDCS sessions. Long-lasting effects were measured 1 and 3 months after the 10th tDCS session. Results: Compared with the sham tDCS, active tDCS significantly decreased OCD symptoms immediately after the 10th tDCS session (F(1,19) = 5.26, p = 0.03). However, no significant differences were observed between the active and sham groups in terms of changes in YBOCS score or the number of responders one and 3 months after tDCS. Conclusion: Despite significant acute effects, tDCS with the cathode placed over the left OFC and the anode placed over the right cerebellum was not significantly effective in inducing a long-lasting reduction of symptoms in patients with treatment-resistant OCD.

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Section: Discussionmentioning

confidence: 99%

Transcranial direct current stimulation in patients with obsessive compulsive disorder: A randomized controlled trial

et al. 2019

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“…; Turski et al . ). For example, HD‐tDCS of the motor cortex has been shown to increase cortical excitability for prolonged periods directly beneath the site of stimulation, as measured by motor evoked potentials (MEPs) using transcranial magnetic stimulation (Kuo et al .…”

Section: Introductionmentioning

confidence: 97%

“…Fortunately, the use of high-definition tDCS (HD-tDCS) partially circumvents this issue through a 4 × 1 electrode montage, with a central electrode surrounded by four electrodes of opposing polarity. Such design provides a more focal and potentially more selective form of neuromodulation (Edwards et al 2013;Kuo et al 2013;Turski et al 2017). For example, HD-tDCS of the motor cortex has been shown to increase cortical excitability for prolonged periods directly beneath the site of stimulation, as measured by motor evoked potentials (MEPs) using transcranial magnetic stimulation (Kuo et al 2013).…”

Section: Introductionmentioning

confidence: 99%

High‐definition transcranial direct current stimulation dissociates fronto‐visual theta lateralization during visual selective attention

Spooner

Eastman

Rezich

et al. 2020

The Journal of Physiology

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Key points Visual attention involves discrete multispectral oscillatory responses in visual and ‘higher‐order’ prefrontal cortices. Prefrontal cortex laterality effects during visual selective attention are poorly characterized. High‐definition transcranial direct current stimulation dynamically modulated right‐lateralized fronto‐visual theta oscillations compared to those observed in left fronto‐visual pathways. Increased connectivity in right fronto‐visual networks after stimulation of the left dorsolateral prefrontal cortex resulted in faster task performance in the context of distractors. Our findings show clear laterality effects in theta oscillatory activity along prefrontal–visual cortical pathways during visual selective attention. Abstract Studies of visual attention have implicated oscillatory activity in the recognition, protection and temporal organization of attended representations in visual cortices. These studies have also shown that higher‐order regions such as the prefrontal cortex are critical to attentional processing, but far less is understood regarding prefrontal laterality differences in attention processing. To examine this, we selectively applied high‐definition transcranial direct current stimulation (HD‐tDCS) to the left or right dorsolateral prefrontal cortex (DLPFC). We predicted that HD‐tDCS of the left versus right prefrontal cortex would differentially modulate performance on a visual selective attention task, and alter the underlying oscillatory network dynamics. Our randomized crossover design included 27 healthy adults that underwent three separate sessions of HD‐tDCS (sham, left DLPFC and right DLPFC) for 20 min. Following stimulation, participants completed an attention protocol during magnetoencephalography. The resulting oscillatory dynamics were imaged using beamforming, and peak task‐related neural activity was subjected to dynamic functional connectivity analyses to evaluate the impact of stimulation site (i.e. left and right DLPFC) on neural interactions. Our results indicated that HD‐tDCS over the left DLPFC differentially modulated right fronto‐visual functional connectivity within the theta band compared to HD‐tDCS of the right DLPFC and further, specifically modulated the oscillatory response for detecting targets among an array of distractors. Importantly, these findings provide network‐specific insight into the complex oscillatory mechanisms serving visual selective attention.

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“…These have shown that that tDCS can modulate brain activity, as measured by hemodynamic changes, with effects seen remote from the site of stimulation measured by Blood Oxygenation Level Dependent (BOLD) fMRI (Amadi, Ilie, Johansen‐Berg, & Stagg, ; Antal, Polania, Schmidt‐Samoa, Dechent, & Paulus, ; Polania, Paulus, & Nitsche, ; Sehm, Kipping, Schäfer, Villringer, & Ragert, ; Stagg & Johansen‐berg, ). A previous study using high‐density tDCS (HD‐tDCS), which permits multiple cephalic sites to be simultaneously targeted, also suggests that modulation of whole networks is possible and behaviorally relevant (Turski et al, ). This study provided some evidence that changes in EEG power were correlated with performance on a cognitive battery.…”

Section: Introductionmentioning

confidence: 99%

Brain state and polarity dependent modulation of brain networks by transcranial direct current stimulation

Violante

Leech

et al. 2018

Human Brain Mapping

116

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Despite its widespread use in cognitive studies, there is still limited understanding of whether and how transcranial direct current stimulation (tDCS) modulates brain network function. To clarify its physiological effects, we assessed brain network function using functional magnetic resonance imaging (fMRI) simultaneously acquired during tDCS stimulation. Cognitive state was manipulated by having subjects perform a Choice Reaction Task or being at “rest.” A novel factorial design was used to assess the effects of brain state and polarity. Anodal and cathodal tDCS were applied to the right inferior frontal gyrus (rIFG), a region involved in controlling activity large-scale intrinsic connectivity networks during switches of cognitive state. tDCS produced widespread modulation of brain activity in a polarity and brain state dependent manner. In the absence of task, the main effect of tDCS was to accentuate default mode network (DMN) activation and salience network (SN) deactivation. In contrast, during task performance, tDCS increased SN activation. In the absence of task, the main effect of anodal tDCS was more pronounced, whereas cathodal tDCS had a greater effect during task performance. Cathodal tDCS also accentuated the within-DMN connectivity associated with task performance. There were minimal main effects of stimulation on network connectivity. These results demonstrate that rIFG tDCS can modulate the activity and functional connectivity of large-scale brain networks involved in cognitive function, in a brain state and polarity dependent manner. This study provides an important insight into mechanisms by which tDCS may modulate cognitive function, and also has implications for the design of future stimulation studies.

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Extended Multiple-Field High-Definition transcranial direct current stimulation (HD-tDCS) is well tolerated and safe in healthy adults

Cited by 26 publications

References 66 publications

Transcranial direct current stimulation in patients with obsessive compulsive disorder: A randomized controlled trial

Transcranial direct current stimulation in patients with obsessive compulsive disorder: A randomized controlled trial

High‐definition transcranial direct current stimulation dissociates fronto‐visual theta lateralization during visual selective attention

Brain state and polarity dependent modulation of brain networks by transcranial direct current stimulation

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