Extensive Genetic Diversity Identified among Sporadic Methicillin-Resistant Staphylococcus aureus Isolates Recovered in Irish Hospitals between 2000 and 2012

Kinnevey, Peter M.; Shore, Anna C.; Brennan, Gráinne I.; Sullivan, Derek J.; Ehricht, Ralf; Monecke, Stefan; Coleman, David C.

doi:10.1128/aac.02653-13

Cited by 34 publications

(36 citation statements)

References 72 publications

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“…Since then, several retrospective and prospective studies using human S. aureus isolates/samples were carried out in order to search for mecC -MRSA isolates ( Table 1 and Table 2 ) [ 16 , 18 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 ,…”

Section: Detection Of Mecc -Mrsa Isolates In Humentioning

confidence: 99%

“…Importantly, the criteria chosen for the selection of the initial isolates/samples varied significantly. While all S. aureus isolates were collected in some studies [ 29 , 38 , 45 ], only MRSA isolates were included in others [ 24 , 26 , 27 , 28 , 32 , 33 , 36 , 41 , 42 ]. Moreover, several studies were more restrictive and only used isolates that showed characteristics suspected of carrying the mecC gene such as spa types associated with mecC -positive clonal lineages previously described, mecA -negative MRSA isolates, isolates with antimicrobial susceptibility suspected to be mecC -positive or pvl -negative MRSA isolates [ 25 , 26 , 37 , 69 ] ( Table S1 ).…”

Section: Detection Of Mecc -Mrsa Isolates In Humentioning

confidence: 99%

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Human mecC-Carrying MRSA: Clinical Implications and Risk Factors

et al. 2020

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A new methicillin resistance gene, named mecC, was first described in 2011 in both humans and animals. Since then, this gene has been detected in different production and free-living animals and as an agent causing infections in some humans. The possible impact that these isolates can have in clinical settings remains unknown. The current available information about mecC-carrying methicillin resistant S. aureus (MRSA) isolates obtained from human samples was analyzed in order to establish its possible clinical implications as well as to determine the infection types associated with this resistance mechanism, the characteristics of these mecC-carrying isolates, their possible relation with animals and the presence of other risk factors. Until now, most human mecC-MRSA infections have been reported in Europe and mecC-MRSA isolates have been identified belonging to a small number of clonal complexes. Although the prevalence of mecC-MRSA human infections is very low and isolates usually contain few resistance (except for beta-lactams) and virulence genes, first isolates harboring important virulence genes or that are resistant to non-beta lactams have already been described. Moreover, severe and even fatal human infection cases have been detected. mecC-carrying MRSA should be taken into consideration in hospital, veterinary and food safety laboratories and in prevention strategies in order to avoid possible emerging health problems.

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Section: Detection Of Mecc -Mrsa Isolates In Humentioning

confidence: 99%

Section: Detection Of Mecc -Mrsa Isolates In Humentioning

confidence: 99%

Human mecC-Carrying MRSA: Clinical Implications and Risk Factors

et al. 2020

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“…These include the distribution of dominant healthcare-associated MRSA (HA-MRSA) in hospitals, which may differ according to the geographic location and time period, 30 the introduction of both community-associated MRSA (CA-MRSA) and livestockassociated MRSA (LA-MRSA) clones in the hospital setting, 14 the emergence of clones carrying Staphylococcal cassette chromosome mec (SCCmec) XI, 22 and extensive genetic diversity among sporadic MRSA isolates. 13 This large variety of clones with their different antimicrobial resistance potential means that information on MRSA clonal distribution in hospitals and the clinical repercussion is essential.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Resistance and Molecular Analysis of Methicillin-ResistantStaphylococcus aureusCollected in a Spanish Hospital

Hernández-Porto

Lecuona

Aguirre‐Jaime

et al. 2015

Microbial Drug Resistance

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Clonal distribution of methicillin-resistant Staphylococcus aureus (MRSA) in hospitals may differ according to the geographic location and time period. Knowledge of MRSA clonal epidemiology in hospital settings involves much more than the study of healthcare-associated MRSA (HA-MRSA) clones. In recent years, investigators have documented the introduction of both community-associated MRSA (CA-MRSA) and livestock-associated MRSA (LA-MRSA) clones, the emergence of clones carrying Staphylococcal cassette chromosome mec (SCCmec) XI, and the genetic diversity among sporadic MRSA isolates. The allocation of certain antibiotypes to dominant MRSA clones in an institution allows their use as phenotypic markers for a preliminary search for new clones, early detection of clonal shift, and as a guide for better empirical therapy, infection control, and treatment within a particular institution. For these reasons, we identified 938 strains detected in a System of Universal Active Surveillance of MRSA in clinical samples during the period 2009-2010, obtaining the clonal distribution of MRSA at the Hospital Universitario de Canarias (Tenerife, Spain) and the relationship between antimicrobial susceptibility and three major clones present. The antibiotypes that best defined the ST5-MRSA-IV (Pediatric) clone showed resistance to tobramycin and susceptibility to clindamycin, erythromycin, gentamicin, rifampin, trimethoprim-sulfamethoxazole, vancomycin, quinupristin/dalfopristin, and linezolid, whereas the ST22-MRSA-IV clone (EMRSA-15) showed susceptibility to these antibiotics, and finally, the ST36-MRSA-II clone (EMRSA-16) was resistant to clindamycin, erythromycin, and tobramycin and susceptible to the remaining antimicrobials. Similar observations would allow the early detection of changes in clonal epidemiology by analysis of antimicrobial susceptibility of the isolates within a single institution.

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“…To date, mecC has been identified in S . aureus isolates belonging to the animal-associated CCs 49, 130, 425, 599 and 1943; and mecC MRSA have been isolated from humans, mainly from different Western and Central European countries, but also from diverse animal species including cattle, sheep, hedgehogs, dogs, cats, a harbor seal ( Phoca vitulina ), a guinea pig, rabbits, rats, and a chaffinch ( Fringilla coelebs ) [39,76,86,87,89,90,91,92,93,94,95,96,97,98,99,100,101,102]. Recently, mecC was also identified in veterinary Staphylococcus xylosus [103] and Staphylococcus stepanovicii [104] isolates.…”

Section: Introductionmentioning

confidence: 99%

Diversity of Staphylococcus aureus Isolates in European Wildlife

et al. 2016

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Staphylococcus aureus is a well-known colonizer and cause of infection among animals and it has been described from numerous domestic and wild animal species. The aim of the present study was to investigate the molecular epidemiology of S. aureus in a convenience sample of European wildlife and to review what previously has been observed in the subject field. 124 S. aureus isolates were collected from wildlife in Germany, Austria and Sweden; they were characterized by DNA microarray hybridization and, for isolates with novel hybridization patterns, by multilocus sequence typing (MLST). The isolates were assigned to 29 clonal complexes and singleton sequence types (CC1, CC5, CC6, CC7, CC8, CC9, CC12, CC15, CC22, CC25, CC30, CC49, CC59, CC88, CC97, CC130, CC133, CC398, ST425, CC599, CC692, CC707, ST890, CC1956, ST2425, CC2671, ST2691, CC2767 and ST2963), some of which (ST2425, ST2691, ST2963) were not described previously. Resistance rates in wildlife strains were rather low and mecA-MRSA isolates were rare (n = 6). mecC-MRSA (n = 8) were identified from a fox, a fallow deer, hares and hedgehogs. The common cattle-associated lineages CC479 and CC705 were not detected in wildlife in the present study while, in contrast, a third common cattle lineage, CC97, was found to be common among cervids. No Staphylococcus argenteus or Staphylococcus schweitzeri-like isolates were found. Systematic studies are required to monitor the possible transmission of human- and livestock-associated S. aureus/MRSA to wildlife and vice versa as well as the possible transmission, by unprotected contact to animals. The prevalence of S. aureus/MRSA in wildlife as well as its population structures in different wildlife host species warrants further investigation.

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Extensive Genetic Diversity Identified among Sporadic Methicillin-Resistant Staphylococcus aureus Isolates Recovered in Irish Hospitals between 2000 and 2012

Cited by 34 publications

References 72 publications

Human mecC-Carrying MRSA: Clinical Implications and Risk Factors

Human mecC-Carrying MRSA: Clinical Implications and Risk Factors

Antimicrobial Resistance and Molecular Analysis of Methicillin-ResistantStaphylococcus aureusCollected in a Spanish Hospital

Diversity of Staphylococcus aureus Isolates in European Wildlife

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