“…Recent studies have revealed the somatic mutation landscape of different normal human tissues, including the skin 3,4 , esophagus 5,6 , colon and rectum 7 , liver 8 , endometrial epithelium 9 , bronchia 10 , brain 11,12 , embryo 13 , urothelium 14,15 , and blood cells 16,17 , mostly through deep DNA sequencing of biopsied tissue samples. Other studies have implemented bioinformatic algorithms to detect somatic mutations from RNA sequencing data of normal human tissues 18,19 .…”