2018
DOI: 10.1097/inf.0000000000001868
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Extensive Necrotic Skin Lesions Due to Post-varicella Protein S Deficiency

Abstract: Postvaricella protein S deficiency is a rare and severe disease. We report a case of extensive necrotic skin lesions of acute onset 7 days after varicella in a 4-year-old girl. Protein S antigen and activity were <10%, and antiprotein S antibodies were detected. She was treated with anticoagulation, plasmapheresis and fresh frozen plasma. She survived but required leg amputation.

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