Site effects in consequence of the 2016-2018 Central Italy seismic sequence "marked the fate" of many villages located close to the epicenters along the Apennine chain. Pescara del Tronto, a small settlement located on a mountain slope in the municipality of Arquata del Tronto, (AP) is very representative of such territories since, early after the onset of the seismic sequence, suffered very impressive site effects, including a large seismicallyinduced debris flow and a high number of small volume landslides. This paper describes the main results of the scientific activities carried out by the authors in this locality in the framework of the unprecedented large-scale Seismic Microzonation project funded by Italian Government in Central Italy for 138 territories. Through an intense field activity, the geological and geomorphologic setting of the study area were revised and updated, including a landslide susceptibility assessment that helped the Italian Department of Civil Protection in the emergency management for temporary housing and, later on, was included in the 3rd Level Seismic Microzonation study implemented by authors while the seismic sequence was still ongoing. A very detailed and reliable subsoil model for this municipality was defined, despite difficulties faced in performing direct and indirect investigations due to the safety restrictions for many areas. The Local Seismic Site response was finally assessed for this locality and the results discussed. A key role in the occurrence of strong site effects into Pescara del Tronto has been played by quaternary deposits having an unexpected heterogeneity under the old village.