Extensively calcified synovial sarcoma

Reyes, Jorge Mario Sánchez; Mexia, M Alcaraz; Tapia, Daniela; Aramburu, J. A.

doi:10.1007/s002560050309

Cited by 33 publications

(3 citation statements)

References 7 publications

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“…A more favorable prognosis, on the other hand, is linked to extensive calcification and tumor size below 5 cm [31,79]. Notably, Baheti et al found that none of the six patients with calcifications in their study had expired [10].…”

Section: Prognostic Imaging Features On Ct and Mrimentioning

confidence: 80%

Synovial Sarcoma in the Extremity: Diversity of Imaging Features for Diagnosis and Prognosis

Cho,

Lee,

Kim

et al. 2023

Cancers

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Synovial sarcomas are rare and highly aggressive soft-tissue sarcomas, primarily affecting adolescents and young adults aged 15–40 years. These tumors typically arise in the deep soft tissues, often near the large joints of the extremities. While the radiological features of these tumors are not definitely indicative, the presence of calcification in a soft-tissue mass (occurring in 30% of cases), adjacent to a joint, strongly suggests the diagnosis. Cross-sectional imaging characteristics play a crucial role in diagnosing synovial sarcomas. They often reveal significant characteristics such as multilobulation and pronounced heterogeneity (forming the “triple sign”), in addition to features like hemorrhage and fluid–fluid levels with septa (resulting in the “bowl of grapes” appearance). Nevertheless, the existence of non-aggressive features, such as gradual growth (with an average time to diagnosis of 2–4 years) and small size (initially measuring < 5 cm) with well-defined margins, can lead to an initial misclassification as a benign lesion. Larger size, older age, and higher tumor grade have been established as adverse predictive indicators for both local disease recurrence and the occurrence of metastasis. Recently, the prognostic importance of CT and MRI characteristics for synovial sarcomas was elucidated. These include factors like the absence of calcification, the presence of cystic components, hemorrhage, the bowl of grape sign, the triple sign, and intercompartmental extension. Wide surgical excision remains the established approach for definitive treatment. Gaining insight into and identifying the diverse range of presentations of synovial sarcomas, which correlate with the prognosis, might be helpful in achieving the optimal patient management.

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Section: Prognostic Imaging Features On Ct and Mrimentioning

confidence: 80%

Synovial Sarcoma in the Extremity: Diversity of Imaging Features for Diagnosis and Prognosis

Cho,

Lee,

Kim

et al. 2023

Cancers

View full text Add to dashboard Cite

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“…been reported to have a better prognosis in some series. 2,4,28 The major drawbacks of our study in general included its retrospective nature, relatively small sample size, and single-centre study. Imaging analysis of our study was limited by the small number of available imaging studies for our patients.…”

Section: Imaging Featuresmentioning

confidence: 98%

Synovial Sarcoma: Epidemiology, Prognosis, and Imaging in a Tertiary Referral Centre

Tsang¹,

Chan²,

Chan³

et al. 2016

Hong Kong J Radiol

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Objectives: To review the disease pattern of synovial sarcoma in a tertiary sarcoma centre in Hong Kong. Methods: Patients with a histological diagnosis of synovial sarcoma from June 2000 to June 2014 were recruited. Patient data were collected using the electronic Patient Record System and available images were reviewed using the Picture Archiving and Communication System. Kaplan-Meier analysis was performed for overall survival. Multivariate Cox regression was performed to evaluate potential prognostic factors. Results: A total of 45 consecutive patients with a mean age of 39 years and male-to-female ratio of 1:1.05 were recruited. Tumours were evident in the lower extremities in 28 (62%) cases, in the upper extremities in four (9%), and elsewhere in 13 (29%). The mean duration of symptoms to diagnosis was 1.5 years. The mean tumour size was 7.0 cm. Metastatic disease was present in 11 (24%) patients at initial diagnosis. The most common site of metastasis was the lung. Nineteen patients died of synovial sarcoma during follow-up. The median survival time was 7.5 years. Tumour size of >5 cm (hazard ratio [HR] = 10.06; 95% confidence interval [CI], 1.30-78.15; p = 0.027) and presence of metastasis at diagnosis (HR = 5.56; 95% CI, 1.20-25.77; p = 0.028) were significant adverse prognostic factors after adjustment for age, gender, tumour location, histological subtypes, and adjuvant therapy. Conclusion: Tumour size of >5 cm and presence of metastasis at diagnosis were identified as adverse prognostic factors.

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“…12). 55 CT better depicts intratumoral calcifications, present in 30% of synovial sarcoma, 56 and bone erosions, seen in 11 to 20% of cases. 57…”

Section: Synovial Sarcomamentioning

confidence: 99%

Neoplastic and Non-neoplastic Soft Tissue Lesions Around the Knee

Chianca,

Curti,

Robba

et al. 2024

Semin Musculoskelet Radiol

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Neoplastic and non-neoplastic soft tissue masses around the knee are often incidental findings. Most of these lesions are benign with typical imaging characteristics that allow a confident diagnosis. However, some of these incidental neoplastic masses are characterized by morbidity and potential mortality. This review highlights the typical aspects of these lesions, facilitating a correct diagnosis.

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Extensively calcified synovial sarcoma

Cited by 33 publications

References 7 publications

Synovial Sarcoma in the Extremity: Diversity of Imaging Features for Diagnosis and Prognosis

Synovial Sarcoma in the Extremity: Diversity of Imaging Features for Diagnosis and Prognosis

Synovial Sarcoma: Epidemiology, Prognosis, and Imaging in a Tertiary Referral Centre

Neoplastic and Non-neoplastic Soft Tissue Lesions Around the Knee

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