Extensively hydrolyzed casein formula alone or with <i>L. rhamnosus </i><scp>GG</scp> reduces β‐lactoglobulin sensitization in mice

Aitoro, Rosita; Simeoli, Raffaele; Amoroso, Antonio; Paparo, Lorella; Nocerino, Rita; Pirozzi, Claudio; Costanzo, Margherita Di; Meli, Rosaria; De, Carmen; Picariello, Gianluca; Mamone, Gianfranco; Calignano, Antonio; Nagler, Cathryn R.; Canani, Roberto Berni

doi:10.1111/pai.12687

Cited by 34 publications

(21 citation statements)

References 35 publications

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“…Moreover, a recent study indicated that ingestion of an extensively hydrolyzed casein formula reduced the level of specific IgE production and the anaphylaxis reaction in β-LG-sensitized mice [38]. Thus, our results also likely reflect this type of antigen nonspecific immunomodulatory effect.…”

Section: Discussion/conclusionsupporting

confidence: 59%

“…Thus, our results also likely reflect this type of antigen nonspecific immunomodulatory effect. However, in contrast to previous studies [36, 38], we evaluated the serum antibodies and anaphylaxis reaction at over 40 days after the end of ingestion periods. Therefore, the suppression of immunoreaction observed in our study was considered to be largely due to antigen-specific oral tolerance.…”

Section: Discussion/conclusionmentioning

confidence: 99%

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Ingestion of Casein Hydrolysate Induces Oral Tolerance and Suppresses Subsequent Epicutaneous Sensitization and Development of Anaphylaxis Reaction to Casein in Mice

Iwamoto

Matsubara

Okamoto

et al. 2019

Int Arch Allergy Immunol

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Background: Casein is the most dominant causal allergen in cow’s milk allergy (CMA). Casein hydrolysates are frequently applied in infant formulas for children with a risk or history of CMA. However, there is limited information on the oral tolerance-inducing ability of casein hydrolysates. Objectives: The aim of this study was to investigate whether the ingestion of casein hydrolysate induces tolerance to casein, ultimately preventing subsequent epicutaneous sensitization and development of an anaphylaxis reaction. Methods: BALB/c mice were orally administered casein or a casein hydrolysate (CNH) via the drinking water and were then epicutaneously sensitized by repeated exposure of casein on tape-stripped skin. Sensitization was assessed by basophil activation tests, the serum levels of casein-specific antibodies, and cytokine production from casein-stimulated spleen and mesenteric lymph node (MLN) cells. Occurrence of an anaphylaxis reaction was evaluated by measuring rectal temperature and the plasma level of mouse mast cell protease-1 (mMCP-1) after oral casein challenges. The T cell population in the spleen and MLN was assessed by flow cytometry. Intestinal mast cells and basophils were analyzed histologically. Results: Sensitization and anaphylaxis reaction to casein were significantly suppressed in casein- or CNH-fed mice compared to controls. Prior ingestion of casein or CNH had no effect on the population of regulatory T cells and activated T cells in lymphoid tissues. Intestinal basophils increased by the epicutaneous sensitization of casein, which was suppressed in casein- or CNH-fed mice. Although the increase in the plasma level of mMCP-1 after oral challenge was suppressed in casein- or CNH-fed mice, there was no change in the number of intestinal mast cells. Conclusion: Prior ingestion of casein or CNH induced oral tolerance and suppressed subsequent epicutaneous sensitization and development of systemic anaphylaxis to casein.

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Section: Discussion/conclusionsupporting

confidence: 59%

Section: Discussion/conclusionmentioning

confidence: 99%

Ingestion of Casein Hydrolysate Induces Oral Tolerance and Suppresses Subsequent Epicutaneous Sensitization and Development of Anaphylaxis Reaction to Casein in Mice

Iwamoto

Matsubara

Okamoto

et al. 2019

Int Arch Allergy Immunol

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show abstract

“…Further, Lundelin et al have shown the long‐term safety of four different strains of probiotics and that the perinatal administration of Lactococcus rhamnosus GG may contribute to the reduction of allergic diseases in children aged 10 years and older. The clinical effect of allergy prevention by Lactobacillus rhamnosus GG has also been confirmed in an animal trial with subsequently decreased sensitization to a common milk allergen …”

mentioning

confidence: 75%

Local rhinitis needs allergen‐challenges for diagnosis, late infancy supplementation of probiotics prevents eczema, and milk oral immunotherapy is effective in the long term

Eigenmann

2019

Pediatric Allergy Immunology

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“…Although the use of probiotics, in conjunction with an extensively hydrolysed formula, offers potentially a new way of CM tolerance induction, to date no official guidelines suggest the routine use of probiotics, by itself or in combination with a hypoallergenic formula to induce tolerance 139. extensively hydrolysed casein formula with and without LGG.…”

mentioning

confidence: 99%

A patient‐specific approach to develop an exclusion diet to manage food allergy in infants and children

Venter

Groetch

Netting

et al. 2018

Clin Experimental Allergy

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Food allergy is becoming increasingly common in infants and young children. This article set out to explain the different factors that should be taken into account during an individualized allergy consultation: Foods to avoid and degree of avoidance, suitable alternatives, self-management skills, co- and cross-reactive allergens and novel allergens alongside the role of the industry in allergen avoidance, importance of nutritional aspects of the diet and the future directions that nutritional guidance make take. Allergy management advice should be individualized to provide a patient-specific approach. Changes in the management of food allergies have in particular occurred in nut, milk and egg allergies over the past few years. There has also been a progressive increase in our understanding of cross-reactivity between different foods and also food and aero-allergens. A patient-specific approach of allergen avoidance should consider factors relating to industry and the environment such as food and nutrition literacy, threshold levels, cross-contact/contamination and safe eating away from home. Increasing migration and travel has also led to exposure of unfamiliar foods. As understanding improves on individual allergens and threshold levels, food labels and food labelling laws are affected. Allergy specialist dietitians should also keep up to date with the latest information on nutrition, the gut microbiome and the immune system to incorporate nutrition strategies in a dietetic consultation using an evidence-based approach.

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Extensively hydrolyzed casein formula alone or with L. rhamnosus GG reduces β‐lactoglobulin sensitization in mice

Abstract: The data support dietary intervention with EHCF for CMA prevention and treatment through a favorable immunomodulatory action. The observed effects are significantly enhanced by LGG supplementation.

Cited by 34 publications

References 35 publications

Ingestion of Casein Hydrolysate Induces Oral Tolerance and Suppresses Subsequent Epicutaneous Sensitization and Development of Anaphylaxis Reaction to Casein in Mice

Ingestion of Casein Hydrolysate Induces Oral Tolerance and Suppresses Subsequent Epicutaneous Sensitization and Development of Anaphylaxis Reaction to Casein in Mice

Local rhinitis needs allergen‐challenges for diagnosis, late infancy supplementation of probiotics prevents eczema, and milk oral immunotherapy is effective in the long term

A patient‐specific approach to develop an exclusion diet to manage food allergy in infants and children

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