2019
DOI: 10.1101/574426
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Extent, heritability, and functional relevance of single cell expression variability in highly homogeneous populations of human cells

Abstract: Because of recent technological developments, single-cell assays such as single-cell RNA sequencing (scRNA-seq) have become much more widely available and have achieved unprecedented resolution in revealing cell heterogeneity. The extent of intrinsic cell-to-cell variability in gene expression, or single cell expression variability (scEV), has thus been increasingly appreciated. However, it remains unclear whether this variability is functionally important and, if so, what its implications are for multi-cellul… Show more

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Cited by 2 publications
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