Extent of Microstructural White Matter Injury in Postconcussive Syndrome Correlates with Impaired Cognitive Reaction Time: A 3T Diffusion Tensor Imaging Study of Mild Traumatic Brain Injury

Niogi, Sumit N.; Mukherjee, Pratik; Ghajar, Jamshid; Johnson, Carl E.; Kolster, Rachel; Sarkar, Ranjeeta; Lee, H.; Meeker, Michele; Zimmerman, Robert D.; Manley, Geoffrey T.; McCandliss, Bruce D.

doi:10.3174/ajnr.a0970

Cited by 536 publications

(422 citation statements)

References 52 publications

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“…FA in white matter regions has been shown to be affected by a variety of factors such as injury, axonal caliber, myelin sheath thickness, and the density and distribution of white matter tracts20. Our findings are consistent with those seen in clinical populations where FA is regularly shown to be reduced following mTBI 41, 42, 43, 44, 45, 46. Decreased FA values have been reported acutely,35 as well as chronically47, in the corpus callosum of patients with mTBI.…”

Section: Discussionsupporting

confidence: 88%

Diffusion MRI abnormalities in adolescent rats given repeated mild traumatic brain injury

Wortman

Meconi

Neale

et al. 2018

Ann Clin Transl Neurol

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ObjectiveMild traumatic brain injury (mTBI) is a serious health concern in the adolescent population. Repeated mTBI may result in more pronounced deficits, and has been associated with long‐term neurological consequences including neurodegeneration. As such, there is a critical need for the development of objective mTBI biomarkers to help guide medical management. Diffusion‐weighted imaging (DWI) is an advanced magnetic resonance imaging (MRI) technique that may detect brain abnormalities after mTBI. Diffusion tensor imaging (DTI) is the most commonly applied DWI method, and initial studies have reported DTI changes in mTBI patients. Furthermore, new DWI methods (e.g., track‐weighted imaging; TWI) are being developed that may also be sensitive to mTBIs, but remain to be comprehensively studied.MethodsThis study utilized the Awake Closed Head Injury (ACHI) model of mTBI to investigate changes in DTI and TWI following repeated mTBI in adolescent male and female rats. A total of four ACHI impacts, two/day over two consecutive days, were delivered beginning on postnatal day 25. At 1 day and 7 days postinjury, rats were euthanized and brains were collected for DWI analyses.ResultsRats given repeated mTBI displayed changes in fractional anisotropy and radial diffusivity (i.e., DTI measures), as well as track density (i.e., TWI).InterpretationThese findings are consistent with initial DTI findings in mTBI patients, suggest that TWI may complement DTI, support the utility of DWI measures as biomarkers in mTBI, and further validate the ACHI rat model of mTBI.

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Section: Discussionsupporting

confidence: 88%

Diffusion MRI abnormalities in adolescent rats given repeated mild traumatic brain injury

Wortman

Meconi

Neale

et al. 2018

Ann Clin Transl Neurol

View full text Add to dashboard Cite

show abstract

“…[162][163][164][165][166] These discrepancies may be due, in part, to the considerable spatial heterogeneity in the brain areas examined, 167 as well as differences in the postinjury interval. FA may still have prognostic value, with evidence suggesting that the direction and magnitude of change correlates with clinical outcomes; 166,168 however, this idea awaits validation in both paediatric and adult populations. FA might lack the necessary sensitivity to fully appreciate changes in white matter tract integrity following brain injury, and measures of diffusivity may be more appropriate.…”

Section: Fluid-based Biomarkersmentioning

confidence: 99%

Mind the gaps—advancing research into short-term and long-term neuropsychological outcomes of youth sports-related concussions

et al. 2015

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“…Previous investigations of TBI patients with white matter damage have shown neuropsychological deficits in speed of processing, working memory, and attention, without a clear gross structural correlate for these deficits. [22][23][24][25] Cognitive and mood disturbances are also prevalent in patients with chronic traumatic encephalopathy (CTE) through postmortem confirmation and review of past medical records. 26 Examination of anatomical correlates with cognitive function can assist in medical guidance prior to manifestation of symptoms.…”

Section: Introductionmentioning

confidence: 99%

White Matter Changes and Confrontation Naming in Retired Aging National Football League Athletes

Strain

Didehbani

Spence

et al. 2017

Journal of Neurotrauma

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Using diffusion tensor imaging (DTI), we assessed the relationship of white matter integrity and performance on the Boston Naming Test (BNT) in a group of retired professional football players and a control group. We examined correlations between fractional anisotropy (FA) and mean diffusivity (MD) with BNT T-scores in an unbiased voxelwise analysis processed with tract-based spatial statistics (TBSS). We also analyzed the DTI data by grouping voxels together as white matter tracts and testing each tract's association with BNT T-scores. Significant voxelwise correlations between FA and BNT performance were only seen in the retired football players ( p < 0.02). Two tracts had mean FA values that significantly correlated with BNT performance: forceps minor and forceps major. White matter integrity is important for distributed cognitive processes, and disruption correlates with diminished performance in athletes exposed to concussive and subconcussive brain injuries, but not in controls without such exposure.

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Extent of Microstructural White Matter Injury in Postconcussive Syndrome Correlates with Impaired Cognitive Reaction Time: A 3T Diffusion Tensor Imaging Study of Mild Traumatic Brain Injury

Cited by 536 publications

References 52 publications

Diffusion MRI abnormalities in adolescent rats given repeated mild traumatic brain injury

Diffusion MRI abnormalities in adolescent rats given repeated mild traumatic brain injury

Mind the gaps—advancing research into short-term and long-term neuropsychological outcomes of youth sports-related concussions

White Matter Changes and Confrontation Naming in Retired Aging National Football League Athletes

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