External Beam Radiation Therapy Enhances Local Control in Pigmented Villonodular Synovitis

Horoschak, Melissa; Tran, Phuoc T.; Bachireddy, Pavan; West, Robert B.; Mohler, David G.; Beaulieu, Christopher F.; Kapp, Daniel S.; Donaldson, Sarah S.

doi:10.1016/j.ijrobp.2008.10.058

Cited by 63 publications

(56 citation statements)

References 20 publications

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“…Berger et al (36) reported an excellent (n = 6) and good (n = 1) joint function 100% of cases. Horoschak et al (38) scored the function as excellent or good in 17 of 18 cases (94 %).…”

Section: Outcome Data and Literature Reviewmentioning

confidence: 99%

“…This treatment regimen corresponds to those in the literature. Total doses of less than 30 Gy (range, 16-26 Gy) has been reported by only a few investigators (26,29,30,37,38) associated with relapse rates of 0% to 14%. Nevertheless, despite these results, the value of total doses less than 30 Gy has not recently been investigated in other studies, and current recommendations include the prescription of total doses in the range of 35 to 40 Gy (4, 27).…”

Section: Process Datamentioning

confidence: 99%

“…Open or arthroscopic synovectomy (9,12,(16)(17)(18)(19)(20), external beam radiation therapy (RT) (21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39), and intra-articular radionuclid application (40)(41)(42)(43) have been shown to be effective for the primary treatment and the management of recurrent disease, either alone or in various combinations. Nevertheless, there is a wide consensus that surgical synovectomy and curettage of bony lesions is the treatment of choice for the primary management of PVNS (4).…”

Section: Introductionmentioning

confidence: 99%

“…After a mean follow up of 46 months two recurrences were observed. The summarization of a comprehensive literature review including 140 sites from 19 studies is given inTable 2(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39). The overall rate of local control shows wide variation ranging from 0 to 100% (median, 100%; mean, 85.4%).…”

mentioning

confidence: 99%

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Radiation Therapy for Treatment of Pigmented Villonodular Synovitis: Results of a National Patterns of Care Study

Heyd¹,

Micke

Berger

et al. 2010

International Journal of Radiation Oncology*Biology*Physics

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“…Berger et al (36) reported an excellent (n = 6) and good (n = 1) joint function 100% of cases. Horoschak et al (38) scored the function as excellent or good in 17 of 18 cases (94 %).…”

Section: Outcome Data and Literature Reviewmentioning

confidence: 99%

Section: Process Datamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Radiation Therapy for Treatment of Pigmented Villonodular Synovitis: Results of a National Patterns of Care Study

Heyd¹,

Micke

Berger

et al. 2010

International Journal of Radiation Oncology*Biology*Physics

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“…Pigmented villonodular synovitis (PVNS) is a rare proliferative disease of the synovium with locally aggressive behaviour and high relapse rates after surgical removal [1]. The etiology of PVNS is unknown but the possible mechanism is thought to be associated with reactive process, repetitive microtraumatic or inflammatory events with synovial hemosiderin deposition [2].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of patients with diffuse pigmented villonodular synovitis of knee with functional scoring systems after surgery and radiosynovectomy

Atilgan¹,

Sadic²,

Özsoy³

et al. 2016

Nucl Med Biomed Imaging

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Aim: To evaluate the symptoms and functional status of patients with pigmented villonodular synovitis (PVNS) of the knee using the modified Marshall scoring system and musculoskeletal tumor society (MSTS) rating scale before therapy and six months after radiosynovectomy (RS). Materials and methods:Evaluation was made of 29 knee joints of 29 patients with DPVNS. Arthroscopic synovectomy was applied to all patients and additional posterior open synovectomy to five. Yittrium-90 (Y-90) citrate colloid was used in the RS procedure. RS was performed 11.8 ± 13.3 weeks after the operation. In the six months after RS, patients were evaluated with the modified Marshall scoring system and MSTS rating scale. Results:The patients were 17 females and 12 males with a mean age of 31.8 ± 12.9 years (range: 13-54 years). The preoperative modified Marshall score was poor in 24 patients and fair in five patients. In the follow-up period, the scores were excellent in 17 patients, good in 10 patients and fair in two patients. The mean modified Marshall scores increased after the operation and RS from 12.93 ± 2.93 to 25.52 ± 2.90 (p<0.001).The mean MSTS scores increased from 17.52 ± 4.82 to 26.86 ± 2.46 (p<0.001). In one of four patients with a score of 22 and three patients with a score of 24, maximum scores were obtained in the follow-up period with the effect of surgery and RS.Conclusion: RS with Y-90 citrate colloid after surgical excision in the treatment of PVNS is a reliable and efficient treatment method for the increase of functional capacity and decrease of symptoms.

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Long‐term outcome of the treatment of high‐risk tenosynovial giant cell tumor/pigmented villonodular synovitis with radiotherapy and surgery

Griffin

Ferguson

Catton

et al. 2012

Cancer

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External Beam Radiation Therapy Enhances Local Control in Pigmented Villonodular Synovitis

Cited by 63 publications

References 20 publications

Radiation Therapy for Treatment of Pigmented Villonodular Synovitis: Results of a National Patterns of Care Study

Radiation Therapy for Treatment of Pigmented Villonodular Synovitis: Results of a National Patterns of Care Study

Evaluation of patients with diffuse pigmented villonodular synovitis of knee with functional scoring systems after surgery and radiosynovectomy

Long‐term outcome of the treatment of high‐risk tenosynovial giant cell tumor/pigmented villonodular synovitis with radiotherapy and surgery

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