External Beam Radiotherapy in the Management of Differentiated Thyroid Cancer

Ford, Daniel; Giridharan, S.; McConkey, Chris; Hartley, A.; Brammer, Caroline; Watkinson, John; Glaholm, J.

doi:10.1016/s0936-6555(03)00162-6

Cited by 73 publications

(28 citation statements)

References 7 publications

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“…In 2003, Ford et al reported that local recurrence and OS are related to the dose prescribed, based on a small cohort (n = 41), suggesting a dose of a least 50 Gy is needed to impact local control and possibly survival. 49 Our findings concur with the recent management guidelines put forth by the American Thyroid Association Guidelines Taskforce, which considers EBR only for patients with gross residual tumors and in whom further surgery or RIA treatment are likely to be ineffective. 42 According to the relative radioresistance and slow regression rate of PTC, Tuttle et al reported no apparent advantage of EBR for OS, but significant morbidities.…”

Section: External Beam Radiation Therapy (Ebr)supporting

confidence: 88%

Long-Term Follow-Up After Complete Resection of Well-Differentiated Cancer Confined to the Thyroid Gland

et al. 2009

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Background. Papillary or follicular thyroid carcinomas exhibit a relatively benign course. Hence, long-term follow-up studies with well-defined disease stages and treatment details are needed to evaluate treatment strategies. Methods. Patients who underwent complete resection of well-differentiated thyroid carcinoma (WDTC) confined to the thyroid gland between 1972 and 1990 identified from a prospective database were assessed. Follow-up was performed by interview, review of patient charts, and analysis of the Death Registry. Primary endpoints were overall survival (OS) and disease-specific survival (DSS). Review of histology was performed and extent of thyroid resection, postoperative therapy, and recognized prognostic factors but not lymphadenectomy were evaluated. Results. Of 2,867 patients, 213 had complete resection of WDTC confined to the thyroid gland. Follow-up was completed in 166 patients with median age 54.2 (range, 20-85) years, and median follow-up of 27.2 (range, 15.6-34.5) years. The 10-and 20-year OS was 71 and 55%, respectively. DSS at 10 and 20 years was 81 and 69%, respectively, and correlated with age, histology, tumor size, radio-iodide ablation (RIA), and external beam irradiation (EBR) treatment. No patient died of WDTC more than 18 years after resection. Total or near-total thyroidectomy without lymphadenectomy was not superior to partial thyroidectomy. In multivariate analysis for DSS, age was the dominant factor, which correlated with histology.

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Section: External Beam Radiation Therapy (Ebr)supporting

confidence: 88%

Long-Term Follow-Up After Complete Resection of Well-Differentiated Cancer Confined to the Thyroid Gland

et al. 2009

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“…It is indicated as initial treatment or for recurrence of unresectable tumors or local invasion presumed to have macro-or microscopic residual disease, which does not concentrate 131 I. External beam radiotherapy may also be indicated for bone or brain metastases (110,111).…”

Section: Role Of External Beam Radiotherapymentioning

confidence: 99%

European consensus for the management of patients with differentiated thyroid carcinoma of the follicular epithelium

Pacini

Schlumberger

Dralle³

et al. 2006

eur j endocrinol

1,820

1,323

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“…External beam irradiation is used infrequently in the management of thyroid cancer except as a palliative treatment for locally advanced, otherwise unresectable disease (171). There are reports of responses among patients with locally advanced disease (172,173), and improved relapse-free and cause-specific survival (174). It remains unknown whether external beam radiation might reduce the risk for recurrence in the neck after adequate primary surgery and/or radioiodine treatment.…”

Section: Is There a Role For Adjunctive External Beam Irradiation Or mentioning

confidence: 99%

Management Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Taskforce

Cooper

Doherty

Haugen

et al. 2006

Thyroid

1,922

938

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External Beam Radiotherapy in the Management of Differentiated Thyroid Cancer

Cited by 73 publications

References 7 publications

Long-Term Follow-Up After Complete Resection of Well-Differentiated Cancer Confined to the Thyroid Gland

Long-Term Follow-Up After Complete Resection of Well-Differentiated Cancer Confined to the Thyroid Gland

European consensus for the management of patients with differentiated thyroid carcinoma of the follicular epithelium

Management Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Taskforce

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