External counterpulsation stimulation combined with acupuncture for vascular endothelial function in patients with hypertension: A randomized pilot trial

Lin, Meilan; Wang, Xiao-Nv; Ye, Bingbing; Zhang, Jun; Lin, Shuman; Xu, Yiye; Zhou, Jian-Guan; Liu, Si-Pei; Zhou, Shiwei; Guan, Xiafei; Jin, Yan; Wang, Lei

doi:10.1080/10641963.2023.2181355

Cited by 4 publications

(1 citation statement)

References 34 publications

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“…A number of studies indicate that acupuncture regulates ET-1-NO imbalances not only in the heart and serum but also in lungs in animal models with hypertension and asthma. These findings are also observed in patients with hypertension [190][191][192][193][194]. Previous studies show acupuncture's role in improving lung and pulmonary function, exercise capacity and endurance, efficiency of oxygen uptake, oxygen saturation, and quality of life in patients with chronic obstructive pulmonary disease (COPD) [195][196][197][198][199][200][201].…”

Section: Non-pharmacological Therapies: Sympathetic Activity Modulati...mentioning

confidence: 77%

Pulmonary Hypertension: Pharmacological and Non-Pharmacological Therapies

Tsai,

Malik,

Tjen-A-Looi

2024

Preprint

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Pulmonary hypertension (PH) is a severe and chronic disease characterized by increased pulmonary vascular resistance and remodeling often precipitating right-sided heart dysfunction and death. Although the condition is progressive and incurable, current therapies for the disease focus on multiple different drugs and general supportive therapies to manage symptoms and prolong survival, ranging from medications more specific to pulmonary arterial hypertension (PAH) to exercise training. Moreover, there are multiple studies exploring novel experimental drugs and therapies including unique neurostimulation, to help better manage the disease. Here we provide a narrative review focusing on current PH treatments that target multiple underlying biochemical mechanisms, including but not limited to imbalances in vasoconstrictor-vasodilator and autonomic nervous system function, inflammation, and bone morphogenic protein (BMP) signaling. We also focus on the potential of novel therapies for managing PH, focusing on multiple types of neu-rostimulation including acupuncture. Lastly, we also touch upon the disease’s different subgroups, clinical presentations and prognosis, diagnostics, demographics, and cost.

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Section: Non-pharmacological Therapies: Sympathetic Activity Modulati...mentioning

confidence: 77%

Pulmonary Hypertension: Pharmacological and Non-Pharmacological Therapies

Tsai,

Malik,

Tjen-A-Looi

2024

Preprint

View full text Add to dashboard Cite

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Research focus and theme evolution on enhanced external counterpulsation: A bibliometric analysis

Yang,

Lu,

Cheng

et al. 2025

Heliyon

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Effect of acupuncture on quality of life in atrial fibrillation: study protocol for a randomised controlled trial

Li,

Shi,

Wang

et al. 2024

BMJ Open

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IntroductionAtrial fibrillation (AF) is the prevalent cardiac arrhythmia and can significantly impair the quality of life (QoL). Although catheter ablation (CA) is an established treatment for AF,post-procedural complications or perceived inadequate control of AF may diminish the QoL for some patients, potentially even to levels lower than pre-procedure. Preliminary findings from our previous pilot trial indicate that acupuncture may positively influence QoL in AF patients post-CA. This study aims to increase the sample size to evaluate the efficacy of acupuncture as an adjunctive treatment to conventional medical therapy in improving QoL of patients with AF after CA.Methods and designThis multicentre randomised clinical trial will be conducted in China. A total of 146 eligible patients will be randomly assigned in a 1:1 ratio to either the acupuncture group or the sham acupuncture group. All patients will receive standard postablation care and undergo 18 sessions of acupuncture/sham acupuncture within 12 weeks following CA, followed by a 9-month follow-up period. The primary outcome is the change in the Atrial Fibrillation Effect on Quality-of-Life (AFEQT) summary score from baseline to months 6 after CA. Secondary outcomes include the changes in the AFEQT subscale scores at months 6, the AFEQT summary and subscale score at months 3 and 12, AF burden, AF recurrence, heart rate variability, number of cardioversions, repeat CA procedures, European Heart Rhythm Association score, number of arrhythmia-related hospitalisations, average heart rate, use of Six-Dimensional Health State Short Form to assess health status, costs incurred by disease treatment, Credibility/Expectancy Questionnaire and blinded assessments. Adverse events will also be meticulously recorded throughout the trial.Ethics and disseminationEthics approval has been granted by the Ethics Committee of Beijing University of Traditional Chinese Medicine (approval no: 2020BZYLL0802) and seven other subcentres. The findings of the study results will be disseminated through presentations at scientific conferences or publications in peer-reviewed journals.Trial registration numberChiCTR2100049323.

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External counterpulsation stimulation combined with acupuncture for vascular endothelial function in patients with hypertension: A randomized pilot trial

Cited by 4 publications

References 34 publications

Pulmonary Hypertension: Pharmacological and Non-Pharmacological Therapies

Pulmonary Hypertension: Pharmacological and Non-Pharmacological Therapies

Research focus and theme evolution on enhanced external counterpulsation: A bibliometric analysis

Effect of acupuncture on quality of life in atrial fibrillation: study protocol for a randomised controlled trial

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