External dose reconstruction in tooth enamel of Techa riverside residents

Shishkina, E.A.; Volchkova, A Yu; Timofeev, Yu. S.; Fattibene, P.; Wieser, A.; Иванов, Д.; Krivoschapov, V. A.; Zalyapin, V.I.; Monaca, Sara Della; Coste, V. De; Anspaugh, L.R.

doi:10.1007/s00411-016-0666-1

Cited by 15 publications

(14 citation statements)

References 39 publications

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“…Differences between our results and literature data lay on the fact that the bones analyzed herein were located a little further from the hypocenter. Another difference was the scattering and attenuation effects of the building materials of the samples used here (Hap) and in references [ 22 ] and [ 25 ] (quartz). Our results also agreed with data published by Ikeya [ 28 ], who found (2.1 ± 0.2) Gy in the shell button and (3.1 ± 0.5) Gy in dental enamel.…”

Section: Discussionmentioning

confidence: 95%

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Electron spin resonance (ESR) dose measurement in bone of Hiroshima A-bomb victim

2018

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Explosion of the bombs in Hiroshima and Nagasaki corresponds to the only historical moment when atomic bombs were used against civilians. This event triggered countless investigations into the effects and dosimetry of ionizing radiation. However, none of the investigations has used the victims’ bones as dosimeter. Here, we assess samples of bones obtained from fatal victims of the explosion by Electron Spin Resonance (ESR). In 1973, one of the authors of the present study (SM) traveled to Japan and conducted a preliminary experiment on the victims’ bone samples. The idea was to use the paramagnetism induced in bone after irradiation to measure the radiation dose. Technological advances involved in the construction of spectrometers, better knowledge of the paramagnetic center, and improvement in signal processing techniques have allowed us to resume the investigation. We obtained a reconstructed dose of 9.46 ± 3.4 Gy from the jawbone, which was compatible with the dose distribution in different locations as measured in non-biological materials such as wall bricks and roof tiles.

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Section: Discussionmentioning

confidence: 95%

“…Another interesting aspect was pointed out by Degteva [ 21 ] and Shishkina [ 22 ]. When there is absorption of radioactive material that is incorporated into hard tissues as bone and tooth, as in the case of downstream settlements residents of Techa River, who were contaminated by 90 Sr.…”

Section: Introductionmentioning

confidence: 96%

Electron spin resonance (ESR) dose measurement in bone of Hiroshima A-bomb victim

2018

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“…Additionally, EPR data have been collected after incorporation of radionuclides leading to an internal dose component, which can also be detected, e.g., by teeth enamel. These studies examined the intake of 239,240 Pu, 137 Cs and 98,90 Sr by the populations living around the Semipalatinsk test site [75][76][77] as well as the intake of 89,90 Sr and 137 Cs by the population living near the Techa River [78,79]. However, EPR was shown to be most applicable when radionuclides are distributed homogenously in the body [80].…”

Section: Epr Dosimetrymentioning

confidence: 99%

Contribution of Biological and EPR Dosimetry to the Medical Management Support of Acute Radiation Health Effects

et al. 2021

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In this review, we discuss the value of biological dosimetry and electron paramagnetic resonance (EPR) spectroscopy in the medical management support of acute radiation syndrome (ARS). Medical management of an ionizing radiation scenario requires significant information. For optimal medical aid, this information has to be rapidly (< 3 days) delivered to the health-care provider. Clinical symptoms may initially enable physicians to predict ARS and initiate respective medical treatment. However, in most cases at least further verification through knowledge on radiation exposure details is necessary. This can be assessed by retrospective dosimetry techniques, if it is not directly registered by personal dosimeters. The characteristics and potential of biological dosimetry and electron paramagnetic resonance (EPR) dosimetry using human-derived specimen are presented here. Both methods are discussed in a clinical perspective regarding ARS diagnostics. The presented techniques can be used in parallel to increase screening capacity in the case of mass casualties, as both can detect the critical dose of 2 Gy (whole body single dose), where hospitalization will be considered. Hereby, biological dosimetry based on the analysis of molecular biomarkers, especially gene expression analysis, but also in vivo EPR represent very promising screening tools for rapid triage dosimetry in early-phase diagnostics. Both methods enable high sample throughput and potential for point-of-care diagnosis. In cases of higher exposure or in small-scale radiological incidents, the techniques can be used complementarily to understand important details of the exposure. Hereby, biological dosimetry can be employed to estimate the whole body dose, while EPR dosimetry on nails, bone or teeth can be used to determine partial body doses. A comprehensive assessment will support optimization of further medical treatment. Ultimately, multipath approaches are always recommended. By tapping the full potential of all diagnostic and dosimetric methods, effective treatment of patients can be supported upon exposure to radiation.

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“…Because of the biokinetics in teeth, these doses are only absorbed in tooth enamel and are not associated with exposures to other organs or the whole body. Tooth samples from a number of residents of Upper Techa were analyzed using both thermoluminescent (TL) dosimetry (Göksu et al 2002 ; Shishkina et al 2014 ) and EPR techniques to assess 90 Sr concentration and related doses and dose rates separately in dentine and enamel (Shishkina et al 2016 ). These results were used for calculating internal doses in enamel and interpretation of the measured absorbed dose by EPR.…”

Section: Scenarios Involving Incorporation Of Radionuclidesmentioning

confidence: 99%

Eurados review of retrospective dosimetry techniques for internal exposures to ionising radiation and their applications

Giussani

López

Romm

et al. 2020

Radiat Environ Biophys

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This work presents an overview of the applications of retrospective dosimetry techniques in case of incorporation of radionuclides. The fact that internal exposures are characterized by a spatially inhomogeneous irradiation of the body, which is potentially prolonged over large periods and variable over time, is particularly problematic for biological and electron paramagnetic resonance (EPR) dosimetry methods when compared with external exposures. The paper gives initially specific information about internal dosimetry methods, the most common cytogenetic techniques used in biological dosimetry and EPR dosimetry applied to tooth enamel. Based on real-case scenarios, dose estimates obtained from bioassay data as well as with biological and/or EPR dosimetry are compared and critically discussed. In most of the scenarios presented, concomitant external exposures were responsible for the greater portion of the received dose. As no assay is available which can discriminate between radiation of different types and different LETs on the basis of the type of damage induced, it is not possible to infer from these studies specific conclusions valid for incorporated radionuclides alone. The biological dosimetry assays and EPR techniques proved to be most applicable in cases when the radionuclides are almost homogeneously distributed in the body. No compelling evidence was obtained in other cases of extremely inhomogeneous distribution. Retrospective dosimetry needs to be optimized and further developed in order to be able to deal with real exposure cases, where a mixture of both external and internal exposures will be encountered most of the times.

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External dose reconstruction in tooth enamel of Techa riverside residents

Cited by 15 publications

References 39 publications

Electron spin resonance (ESR) dose measurement in bone of Hiroshima A-bomb victim

Electron spin resonance (ESR) dose measurement in bone of Hiroshima A-bomb victim

Contribution of Biological and EPR Dosimetry to the Medical Management Support of Acute Radiation Health Effects

Eurados review of retrospective dosimetry techniques for internal exposures to ionising radiation and their applications

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