External Electric Muscle Stimulation Improves Burning Sensations and Sleeping Disturbances in Patients with Type 2 Diabetes and Symptomatic Neuropathy

Humpert, Per M.; Morcos, Michael; Oikonomou, Dimitrios; Schaefer, Karin; Hamann, Andreas; Bierhaus, Angelika; Schilling, Tobias; Nawroth, Peter P.

doi:10.1111/j.1526-4637.2008.00557.x

Cited by 30 publications

(29 citation statements)

References 21 publications

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“…HTEMS currently is widely used in pain treatment of patients of diabetic and uremic polyneuropathy and is well tolerated [43,44,45].…”

Section: Intervention By High Tone Electrical Muscle Stimulationmentioning

confidence: 99%

High-frequency external muscle stimulation in acute kidney injury (AKI): potential shortening of its clinical course

Iorio¹,

Torraca²,

Gustaferro³

et al. 2012

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Background: The prognosis of acute kidney injury (AKI) is markedly influenced by the degree of muscle protein catabolism. Since the current therapeutic strategies are rather limited, for the first time, we attempted to attenuate the hypercatabolism by high tone electrical muscle stimulation (HTEMS) in AKI patients. This kind of therapy may lower protein degradation via its effect on muscle activity as well as improving insulin resistance. Moreover, electrotherapy may improve renal function due to circulatory effects as well as lowering the sympathetic tone. Methods: 34 patients with AKI Stage 3 were included; all required daily hemodialysis with a dose of Kt/V urea > 1. The patients were randomized into two groups of 17 patients each with and without HTEMS. The groups were comparable with regard to age, gender, underlying diseases, causes of AKI and the baseline biochemistry. HTEMS was performed intradialytically for 1 h. This new electromedical device is characterized by changes in the carrier frequency between 4,100 and 33,000 Hz in short intervals and also the amplitude and frequency are modulated simultaneously. Results: The treatment was well tolerated and associated with an improved clinical outcome. As compared to the untreated patients the HTEMS group showed a significant shorter duration of oliguria, a faster decline of serum creatinine and urea levels, less need of dialysis treatment and a shorter period of hospitalization. The decline of urea was more marked than that of serum creatinine resulting in a significant lowering of the urea/creatinine ratio. This finding suggests a reduced catabolism of muscle proteins which-via a lower release of amino acids into the circulation-results in a decline of hepatic ureagenesis. We hypothesize that in our AKI patients the improved protein catabolism contributed to the shortening of the clinical course of acute re-nal failure. Conclusion: This study suggests for the first time that HTEMS treatment of patients with AKI during hemodialysis is associated with an improved clinical outcome. To support this novel observation, a randomized controlled trial with a greater number of more homogenous AKI patients should be performed.

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“…HTEMS currently is widely used in pain treatment of patients of diabetic and uremic polyneuropathy and is well tolerated [43,44,45].…”

Section: Intervention By High Tone Electrical Muscle Stimulationmentioning

confidence: 99%

High-frequency external muscle stimulation in acute kidney injury (AKI): potential shortening of its clinical course

Iorio¹,

Torraca²,

Gustaferro³

et al. 2012

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“…A study by Humpert et al. [20] evaluated uncontrolled and prospectively the effect of high‐frequency external muscle stimulation on diabetic neuropathic pain. Here, >70% of the patients noted an improvement in neuropathy‐related burning sensations and sleep disturbances.…”

Section: Discussionmentioning

confidence: 99%

“…Although not tested against a placebo, evidence of pain reduction in >65% of the patients treated with muscle stimulation, compared to only 25% of the patients treated with TENS, was an impressive result. A study by Humpert et al [20] evaluated uncontrolled and prospectively the effect of high-frequency external muscle stimulation on diabetic neuropathic pain. Here, >70% of the patients noted an improvement in neuropathy-related burning sensations and sleep disturbances.…”

Section: Discussionmentioning

confidence: 99%

Microcurrent Transcutaneous Electric Nerve Stimulation in Painful Diabetic Neuropathy: A Randomized Placebo-Controlled Study

Goßrau¹,

Wähner²,

Kuschke³

et al. 2011

Pain Med

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“…In addition to superior pain relief, the 10 kHz band may provide long-term improvements in quality of life and functionality for subjects with chronic low back and leg pain [77]. On the other hand, a wider band of 4-30 kHz has been used for polyneuropathy (a general degeneration of peripheral nerves that spreads toward the center of the body) electrostimulation treatment [79][80][81][82].…”

Section: Three-dimensional Coil Resonator Design Solenoidal E-fieldmentioning

confidence: 99%

Design and Analysis of a Whole-Body Noncontact Electromagnetic Subthreshold Stimulation Device with Field Modulation Targeting Nonspecific Neuropathic Pain

Makarov

Bogdanov

Noetscher

et al. 2019

Brain and Human Body Modeling

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External Electric Muscle Stimulation Improves Burning Sensations and Sleeping Disturbances in Patients with Type 2 Diabetes and Symptomatic Neuropathy

Abstract: In an uncontrolled setting, EMS seems to be an effective treatment for symptomatic neuropathy in patients with type 2 diabetes, especially in patients with strong symptoms.

Cited by 30 publications

References 21 publications

High-frequency external muscle stimulation in acute kidney injury (AKI): potential shortening of its clinical course

High-frequency external muscle stimulation in acute kidney injury (AKI): potential shortening of its clinical course

Microcurrent Transcutaneous Electric Nerve Stimulation in Painful Diabetic Neuropathy: A Randomized Placebo-Controlled Study

Design and Analysis of a Whole-Body Noncontact Electromagnetic Subthreshold Stimulation Device with Field Modulation Targeting Nonspecific Neuropathic Pain

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