2023
DOI: 10.1016/j.ejps.2023.106416
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External evaluation and systematic review of population pharmacokinetic models for high-dose methotrexate in cancer patients

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Cited by 4 publications
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“…The pulmonary damage of Ara-C manifests as pulmonary edema and is related to the frequency of administration. When high doses were clinically applied to treat acute leukemia, 22% of children developed subacute pulmonary failure, with the first signs of toxicity occurring at an average of 6 d (2–21 d) after initiation of treatment ( YANG et al, 2023 ). CTX and IFO may injure lung tissue through the production of reactive oxygen metabolites.…”
Section: Antitumor Therapy and Adrs In The Respiratorymentioning
confidence: 99%
“…The pulmonary damage of Ara-C manifests as pulmonary edema and is related to the frequency of administration. When high doses were clinically applied to treat acute leukemia, 22% of children developed subacute pulmonary failure, with the first signs of toxicity occurring at an average of 6 d (2–21 d) after initiation of treatment ( YANG et al, 2023 ). CTX and IFO may injure lung tissue through the production of reactive oxygen metabolites.…”
Section: Antitumor Therapy and Adrs In The Respiratorymentioning
confidence: 99%