External power-driven micro/nanorobots: Design, fabrication, and functionalization for tumor diagnosis and therapy

An, Miao; Feng, Ying; Liu, Yang; Yang, Huaming

doi:10.1016/j.pmatsci.2023.101204

Cited by 4 publications

(3 citation statements)

References 344 publications

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“…In Vivo Fluorescence Imaging. In 4T1 tumor-bearing mice, DIR1048 (60 μg/mL, 200 μL) or RDIR1048 (60 μg/mL, 200 μL) was injected into the tail vein, and the fluorescence imaging and quantitative analysis were performed using a NIR-II fluorescence imaging system in different time points (1,2,4,6,8,12,24,36,48,60,72,84, and 96 h). After 96 h, the mice were euthanized, and the tumor tissues and major organs were excised for fluorescence imaging and quantitative analysis.…”

Section: Methodsmentioning

confidence: 99%

“…Integrated diagnosis and treatment strategies can improve the accuracy and precision of treatments and are highly beneficial in treating tumors − because drugs can be targeted and treatments can be monitored in real time. − In recent years, the integration of multiple components that have early tumor diagnosis and in situ treatment functions onto a nanoplatform has facilitated the development of multifunctional diagnostic and therapeutic agents that can monitor treatment efficacies and prognoses in real time . Presently, multimodal imaging, such as fluorescence and thermal imaging, and guided synergistic therapy, such as photothermal therapy (PTT), chemotherapy, and immunotherapy, are commonly integrated for diagnosis and treatment. − …”

Section: Introductionmentioning

confidence: 99%

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Nanoparticles Encapsulated in Red Blood Cell Membranes for Near-Infrared Second Window Imaging-Guided Photothermal-Enhanced Immunotherapy on Tumors

Ye,

Yu,

et al. 2024

ACS Appl. Mater. Interfaces

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Photothermal therapy (PTT), which uses the high thermal conversion ability of photothermal agents to ablate tumor cells at high temperatures, has gained significant attention because it has the advantages of high selectivity and specificity, precise targeting of tumor sites, and low invasiveness and trauma. However, PTT guided by the NIR-I has limitations in tissue penetration depth, resulting in limited imaging monitoring and therapeutic effects on deep-seated tumor tissues. Moreover, nanoparticles are easily cleared by the immune system and difficult to passively target tumor sites during the process of treatment. To address these issues, we prepared nanoparticles using NIR-II dyes IR1048 and DSPE-PEG−OH and further encapsulated them in red blood cell membranes derived from mice. These biomimetic nanoparticles, called RDIR1048, showed reduced clearance by the immune system and had long circulation characteristics. They effectively accumulated at tumor sites, and strong fluorescence could still be observed at the tumor site 96 h after administration. Furthermore, through mouse thermal imaging experiments, we found that RDIR1048 exhibited good PTT ability. When used in combination with an immune checkpoint inhibitor, anti-PD-L1 antibodies, it enhanced the immunogenic cell death of tumor cells caused by PTT and improved the therapeutic effect of immunotherapy, which demonstrated good therapeutic efficacy in the treatment of tumor-bearing mice. This study provides a feasible basis for the future development of NIR-II nanoparticles with long circulation properties.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nanoparticles Encapsulated in Red Blood Cell Membranes for Near-Infrared Second Window Imaging-Guided Photothermal-Enhanced Immunotherapy on Tumors

Ye,

Yu,

et al. 2024

ACS Appl. Mater. Interfaces

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“…Untethered miniature robots are promising candidates for biomedical applications such as disease diagnosis, 1,2 cell manipulation, 3,4 and targeted drug delivery. 5–7 Miniature robots take advantage of their small dimensions to reach tiny sites inside the human body and execute elaborate tasks.…”

Section: Introductionmentioning

confidence: 99%

Magnetic-actuated hydrogel microrobots with multimodal motion and collective behavior

Chen,

Tian,

Zhang

et al. 2024

J. Mater. Chem. B

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Magnetic Hercules Swarm for Precise and Effective Deep Biofilm Eradication

Xu,

Wang,

Lou

et al. 2024

Adv Materials Technologies

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Over the past decade, significant advancements in micro‐nano robots have enabled non‐invasive operations in hazardous, confined environments, particularly targeting persistent bacterial biofilms in hard‐to‐reach areas. However, many of these robots are limited by poor magnetic properties, hindering their effectiveness against biofilms. This study proposes a novel strategy using a swarm with strong magnetic effects (Hercules swarm) combined with near‐infrared (NIR) light for effective biofilm eradication. Carbonyl iron particles coated with polydopamine (CI@PDA), averaging ≈3 µm in diameter, demonstrate clustering and significant magneto‐force under a rotating magnetic field due to their large magnetic saturation. This enables the Hercules swarm to achieve rapid delivery (100 mm s−1), efficient cargo transport (carrying twice its own weight), and effective catheter clearance (1 mm min−1). The controllable motion and high photothermal activity enable precise biofilm eradication without toxic agents. The aggregation of magnetic particles into chains and their rotation are explored by improved particle dynamic model. Simulations also reveal enhanced fluid convection and mechanical pressure around the particle chain. Due to its easy operation, straightforward controllability, and environmental compatibility, the magnetic Hercules swarm emerges as a promising treatment modality for eliminating biofilms entrenched within intricate, narrow, and convoluted medical implants or industrial conduits.

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External power-driven micro/nanorobots: Design, fabrication, and functionalization for tumor diagnosis and therapy

Cited by 4 publications

References 344 publications

Nanoparticles Encapsulated in Red Blood Cell Membranes for Near-Infrared Second Window Imaging-Guided Photothermal-Enhanced Immunotherapy on Tumors

Nanoparticles Encapsulated in Red Blood Cell Membranes for Near-Infrared Second Window Imaging-Guided Photothermal-Enhanced Immunotherapy on Tumors

Magnetic-actuated hydrogel microrobots with multimodal motion and collective behavior

Magnetic Hercules Swarm for Precise and Effective Deep Biofilm Eradication

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