External Quality Assurance of Platelet Function Assays: Results of the College of American Pathologists Proficiency Testing Program

Hartmann, Jan

doi:10.5858/arpa.2019-0115-le

Cited by 1 publication

(1 citation statement)

References 17 publications

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“…A large-scale proficiency testing program performed by the College of American Pathologists assessed data from over 1,000 American laboratories from 2012 to 2016 for several PFT devices: PFA-100, LTA, PlateletWorks (Helena Laboratories, Beaumont, TX), and TEG 5000 analyzer with the PlateletMapping Assay. 44 The highest percentage of correct results compared with a standard reference was observed with PFA-100 and a much lower percentage with TEG 5000; although it has been noted 45 that this did not take into account the context relating to the TEG device as the only comprehensive, whole blood test included in the program that encompasses additional contributors to coagulation, such as platelet fibrin linkage. Additionally, given the relative complexity of the assays, there is likely to be higher operator variability in the TEG 5000 device used in this study compared with the TEG 6s analyzer.…”

Section: Comparison Of the Teg Plateletmapping Assay With Other Pftsmentioning

confidence: 99%

Modified Thromboelastography for Peri-interventional Assessment of Platelet Function in Cardiology Patients: A Narrative Review

Hartmann

Curzen

2022

Semin Thromb Hemost

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Viscoelastic testing (VET), such as thromboelastography, can measure whole blood coagulation dynamics in real time and is used across a range of clinical settings, including cardiac surgery, liver transplant, and trauma. The use of modified thromboelastography with platelet function assessment (TEG(R) PlateletMapping(R) Assay) can provide an analysis of platelet contribution to hemostasis, including the contribution of the P2Y12 receptor and thromboxane pathway to platelet function. The TEG PlateletMapping Assay has shown high correlation with the current gold standard test of platelet function, light transmission aggregometry, to measure arachidonic acid and adenosine diphosphate agonist-induced platelet activation. Studies have also shown comparable results with other whole blood platelet function tests. In this review, we explore the clinical applications of modified thromboelastography with platelet function assessment. This includes guiding dual antiplatelet therapy in relation to cardiac procedures, such as percutaneous coronary interventions, transcatheter aortic valve replacement, and left atrial appendage closure. We also explore the developing use of thromboelastography in the emergency care setting of coronavirus disease 2019, which is commonly associated with a hypercoagulable and hypofibrinolytic state. Despite a general lack of high-quality, grade 1 evidence regarding the use of modified thromboelastography with platelet function assessment in these disease areas, the ability of the TEG PlateletMapping Assay to measure global hemostasis and platelet reactivity rapidly and to view and evaluate results at the point of care makes it a promising area for further study for managing patient treatment and optimizing hemostatic therapy.

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Section: Comparison Of the Teg Plateletmapping Assay With Other Pftsmentioning

confidence: 99%

Modified Thromboelastography for Peri-interventional Assessment of Platelet Function in Cardiology Patients: A Narrative Review

Hartmann

Curzen

2022

Semin Thromb Hemost

Self Cite

View full text Add to dashboard Cite

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External Quality Assurance of Platelet Function Assays: Results of the College of American Pathologists Proficiency Testing Program

Abstract: Cause-specific mortality and cancer morbidity in 390 male workers exposed to high purity talc, a sixdecade follow-up.

Cited by 1 publication

References 17 publications

Modified Thromboelastography for Peri-interventional Assessment of Platelet Function in Cardiology Patients: A Narrative Review

Modified Thromboelastography for Peri-interventional Assessment of Platelet Function in Cardiology Patients: A Narrative Review

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