2022
DOI: 10.1016/j.nbt.2022.08.006
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External Quality Assurance programs for processing methods provide evidence on impact of preanalytical variables

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Cited by 6 publications
(3 citation statements)
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“…Participation in a Proficiency Testing scheme would be beneficial, because these enable a laboratory to compare their processes with their peers, using the same starting material [ [15] , [16] , [17] ]. Consequently, a report advising a laboratory that their processes yield nucleic acids that are unusually degraded suggests there could be a nuclease contamination issue.…”
Section: Discussionmentioning
confidence: 99%
“…Participation in a Proficiency Testing scheme would be beneficial, because these enable a laboratory to compare their processes with their peers, using the same starting material [ [15] , [16] , [17] ]. Consequently, a report advising a laboratory that their processes yield nucleic acids that are unusually degraded suggests there could be a nuclease contamination issue.…”
Section: Discussionmentioning
confidence: 99%
“…These measures encompass the utilization of standard operating procedures (SOPs) and validated protocols, incorporating internal quality controls such as reference materials and control charts, active participation in PT programs, and obtaining certification or accreditation according to recognized standards such as ISO15189/IEC, ISO/IEC 17025 and ISO 9001 (6). Indeed, it has been demonstrated that laboratories engaged in PT programs exhibit robust internal quality control procedures and consistently achieve better z-scores, (7, 8).…”
Section: Proficiency Testing For Assessing Pre-analytical Sample Proc...mentioning
confidence: 99%
“…As such, DNA sample management standardization is useful to obtain DNA of quality, even if genomic DNA appears less sensitive than RNA to factors affecting biospecimen quality [17]. A recent study conducted in the frame of External Quality Assurance (EAQ) program reports that DNA yields are impacted by extraction method and elution buffer, and DNA integrity by extraction method and equipment [18]. Additionally, we performed a retrospective study to analyze the impact of preanalytical factors and patient characteristics (age, sex and BMI) on the quantity of DNA extracted.…”
Section: Tissue Typementioning
confidence: 99%