External Quality Control of Direct Antigen Tests to Detect Group A Streptococcal Antigen

Morandi, Pierre-Alain; Deom, A.; Mauris, Anne; Rohner, Peter

doi:10.1007/s10096-003-1027-y

Cited by 7 publications

(4 citation statements)

References 10 publications

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“…Several studies have shown that participation in an EQAS for POCT analyses is useful to improve analytical quality; e.g., for mononucleosis tests and urine dip-slide tests in Norway (8,9), for group A streptococcus tests in Finland (10) and in Switzerland (11), for hemoglobin tests in Belgium (12) and for blood glucose tests in Germany (13). The United Kingdom National External Quality Assessment Service (UKNEQAS) has reported their experience with EQAS for POCT INR over a 6-year period, and stated that this kind of control is both possible and necessary for health care professionals to obtain good analytical quality (14).…”

Section: Introductionmentioning

confidence: 99%

External quality assessment of point-of-care International Normalized Ratio (INR) testing in Europe

Stavelin

Meijer²,

Kitchen³

et al. 2012

Clinical Chemistry and Laboratory Medicine

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Background: Point-of-care testing (POCT) of prothrombin time, expressed as International Normalized Ratio (INR), is widely used to monitor patients in oral anticoagulation treatment. Guidelines recommend that POCT users should participate in an external quality assessment (EQA) scheme whenever available. The aim of this study was to investigate which European countries provide EQA for POCT INR and to compare how these schemes are organized. Methods: Thirty European countries were invited to participate in this study. Those who reported that they provide EQA for POCT INR filled in a questionnaire dealing with different aspects of their schemes. Results: Nineteen countries reported that they do not provide EQA for POCT INR, while 12 organizations from nine countries reported that they provide this service. Most of these countries circulate lyophilized samples with for the participants unknown target values. Samples with certified INR values and procedures using split samples with fresh patient samples are also used. The acceptability limits vary from 15% to 30%, and the total number of samples circulated per year varies from 1 to 12. Most of the countries organize educational activities together with their schemes. Conclusions: This study demonstrates that there is a wide variation in the way EQA for POCT INR is performed in Europe and that there are many European countries that do not provide this service. Even though our findings indicate that EQA for POCT INR draws some challenges, especially in providing suitable control materials, participation in such schemes is considered useful.

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Section: Introductionmentioning

confidence: 99%

External quality assessment of point-of-care International Normalized Ratio (INR) testing in Europe

Stavelin

Meijer²,

Kitchen³

et al. 2012

Clinical Chemistry and Laboratory Medicine

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“…Чем ниже оценка по клинической шкале и чем меньшее число БГСА, тем менее чувствительна система [19,20]. В различных условиях чувствительность экспресс-тестов может колебаться в пределах 10-95%, а специфичность -в пределах 90-100% [10,21]. В 2010 г. в России зарегистрирован Стрептатест производства французской фармацевтической компании «Dectra» -качественный иммунохроматографический тест для выявления антигенов стрептококка группы А, относится к экспресс-тестам второго поколения.…”

Section: серологическая классификацияunclassified

Modern Methods of Microbiological Diagnostics in Acute Tonsillitis and Chronic Tonsillitis Exacerbations in Children

Белов¹

2012

Vopr. sovr. pediatr.

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Московский научно-исследовательский институт педиатрии и детской хирургии В статье обсуждаются иммунологические и микробиологические особенности хронического тонзиллита у детей и приводятся разные подходы к его лечению. Особое внимание уделено вопросам диагностики главного инфекционного агента-␤-гемолитического стрептококка группы А. Представлен качественный иммунохроматографический экспресс-тест для выявления антигенов стрептококка группы А Стрептатест (Streptatest). Описаны основные принципы рационального применения антибактериальных препаратов при хроническом тонзиллите у детей.

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“…A comparative study showed that this RSAT had the highest sensitivity and specificity in ambulatory medical practice. 21 Throat cultures were incubated on 2 blood agar plates in anaerobia without inhibitor and were read after 48 hours in the Laboratory of Bacteriology, University Hospital of Geneva. Physicians prescribed antibiotic treatment immediately in all patients with positive RSAT results or within 48 hours in patients with a positive throat culture.…”

Section: Data Collectionmentioning

confidence: 99%

Management of Acute Pharyngitis in Adults

Humair¹,

Revaz²,

Bovier³

et al. 2006

Arch Intern Med

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Background: How to use clinical score, the rapid streptococcal antigen test (RSAT), and culture results is uncertain for efficient management of acute pharyngitis in adults. Methods: This prospective cohort study included 372 adult patients with pharyngitis treated at a Swiss university-based primary care clinic. In eligible patients with 2 to 4 clinical symptoms and signs (temperature Ն38°C, tonsillar exudate, tender cervical adenopathy, and no cough or rhinitis), we performed an RSAT and obtained a throat culture. We measured sensitivity and specificity of RSAT with culture as a gold standard and compared appropriate antibiotic use with cost per patient appropriately treated for the following 5 strategies: symptomatic treatment, systematic RSAT, selective RSAT, empirical antibiotic treatment, and systematic culture. Results: RSAT had high sensitivity (91%) and specificity (95%) for the diagnosis of streptococcal pharyngitis. Systematic throat culture resulted in the highest antibiotic use, in 38% of patients with streptococcal pharyngitis. Systematic RSAT led to nearly optimal treatment (94%) and antibiotic prescription (37%), with minimal antibiotic overuse (3%) and underuse (3%). Empirical antibiotic treatment in patients with 3 or 4 clinical symptoms or signs resulted in a lower rate of appropriate therapy (59%) but higher rates of antibiotic use (60%), overuse (32%), and underuse (9%). Systematic RSAT was more cost-effective than strategies based on empirical

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External Quality Control of Direct Antigen Tests to Detect Group A Streptococcal Antigen

Cited by 7 publications

References 10 publications

External quality assessment of point-of-care International Normalized Ratio (INR) testing in Europe

External quality assessment of point-of-care International Normalized Ratio (INR) testing in Europe

Modern Methods of Microbiological Diagnostics in Acute Tonsillitis and Chronic Tonsillitis Exacerbations in Children

Management of Acute Pharyngitis in Adults

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