External urethral sphincter activity in a rat model of pudendal nerve injury

Peng, Chih Wei; Chen, Jia Jin Jason; Chang, Hsung-Pin; Groat, William C. de; Cheng, Chen Li

doi:10.1002/nau.20229

Cited by 98 publications

(146 citation statements)

References 24 publications

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“…Similar low voiding efficiencies were reported in other studies (Cheng and de Groat 2004, Cruz and Downie 2005, Peng et al 2006, and presumably resulted from the urethrane anesthesia inhibiting reflex bladder contractions and reducing the contraction pressure during micturition (Yaksh et al 1986).…”

Section: Discussionsupporting

confidence: 85%

“…Chronic transection of the pudendal nerves produced reductions in detrusor contraction amplitude accompanied by reductions in voiding efficiency that were attributed to the loss of pudendal sensory feedback as well as changes in the EMG burst pattern (Peng et al 2006).…”

Section: Discussionmentioning

confidence: 98%

“…Finally, degeneration of transected sensory fibers in the chronic model may leave them unavailable for stimulation, and although studies show robust reinnervation of the external urethral sphincter by pudendal motor axons (Heidkamp et al 1998, Kerns et al 2000, Peng et al 2006, the fate of damaged or transected sensory neurons is not clear.…”

Section: Discussionmentioning

confidence: 99%

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Improved bladder emptying in urinary retention by electrical stimulation of pudendal afferents

et al. 2008

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Urinary retention is the inability to empty the bladder completely, and may result from bladder hypocontractility, increases in outlet resistance, or both. Chronic urinary retention can lead to several urological complications and is often refractory to pharmacologic, behavioral, and surgical treatments. We sought to determine whether electrical stimulation of sensory fibers in the pudendal nerve could engage an augmenting reflex and thereby improve bladder emptying in an animal model of urinary retention. We measured the efficiency of bladder emptying with and without concomitant electrical stimulation of pudendal nerve afferents in urethane anesthetized rats. Voiding efficiency (VE=voided volume/initial volume) was reduced from 72±7% to 29±7% following unilateral transection of the sensory branch of the pudendal nerve (UST) and from 70±5% to 18±4% following bilateral transection (BST). Unilateral electrical stimulation of the proximal transected sensory pudendal nerve during distention-evoked voiding contractions significantly improved VE. Low intensity stimulation at frequencies of 1-50 Hz increased VE to 40-51% following UST and to 39-49% following BST, while high intensity stimulation was ineffective at increasing VE. The increase in VE was mediated by increases in the duration of distention-evoked voiding bladder contractions, rather than increases in contraction amplitude. These results are consistent with an essential role for pudendal sensory feedback in efficient bladder emptying, and raise the possibility that electrical activation of pudendal nerve afferents may provide a new approach to restore efficient bladder emptying in persons with urinary retention.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 98%

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Improved bladder emptying in urinary retention by electrical stimulation of pudendal afferents

et al. 2008

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“…Additionally, the interruption of sympathetic innervations can slightly increase the frequency and amplitude of bladder contractions (Peng et al, 2006). In a report using three cats with medullar thoracic lesion and urinary retention, treated by electrosurgical denervation of the external and internal urethral sphincters, the micturition was partially restored and allowed complete bladder emptying by manual expression (Tudury et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Surgical procedures used for post-traumatic neurogenic bladder in a cat: report case

Pavan

Rossetto

Rahal

et al. 2011

Arq. Bras. Med. Vet. Zootec.

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A 1-year-old castrated crossbred male cat was referred to the Veterinary Teaching Hospital for evaluation of urinary retention associated with a subluxation at T12-T13 caused by a car accident. Urethral sphincter denervation by transection of hypogastric and pudendal nerves was performed to allow bladder emptying, but after three months post operation the cat had a urinary retention recurrence. Endoscopic urethral sphincterotomy was done resulting in urinary incontinence for four months.Keywords: cat, urinary incontinence, urethral denervation, urethral sphincterotomy -chave: gato, incontinência urinária, denervação uretral, esfincterotomia uretral RESUMO Um gato de um ano de idade, macho, castrado, sem raça definida, foi encaminhado ao Hospital Veterinário Escola para avaliação de retenção urinária associada à subluxação nas vértebras T12-T13, que foi causada por um acidente automobilístico. Realizou-se a denervação do esfíncter uretral, por transecção dos nervos pudendo e hipogástrico, para permitir o esvaziamento da bexiga, porém três meses após a cirurgia inicial o animal apresentou recorrência da retenção urinária. Esfincterotomia endoscópica uretral foi então realizada, resultando em incontinência urinária por quatro meses. Palavras

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“…Several different electrodes have been utilized to study EMGs of pelvic and perineal muscles in rats, including concentric electrodes (Kerns et al 2000), parallel electrodes (Jiang et al 2009a(Jiang et al , 2009b, and wire electrodes (Chang & Havton 2008;Cruz & Downie 2006;Peng et al 2006;Yang et al 2010). Several muscles in or close to the pelvic floor have been studied in rats, including the pubococcygeus, iliococcygeus, EUS, and external anal sphincter (EAS) muscles Salcedo et al 2010;Thor & de Groat 2010).…”

Section: Electrodes and Techniques Used To Measure Pfm Emgs In Laboramentioning

confidence: 99%

Electromyography of Pelvic Floor Muscles in Rats

Gómez¹,

Jiang²,

Zaszczurynski³

et al. 2011

Advances in Applied Electromyography

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External urethral sphincter activity in a rat model of pudendal nerve injury

Abstract: Our results indicate that pudendal nerve transection in rats decreases urethral outlet resistance and causes striated muscle atrophy in the EUS, EUS-EMG abnormalities and inefficient voiding. The results demonstrate that BPNT is a durable model for SUI.

Cited by 98 publications

References 24 publications

Improved bladder emptying in urinary retention by electrical stimulation of pudendal afferents

Improved bladder emptying in urinary retention by electrical stimulation of pudendal afferents

Surgical procedures used for post-traumatic neurogenic bladder in a cat: report case

Electromyography of Pelvic Floor Muscles in Rats

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