Extra-virgin olive oil diet and mild physical activity prevent cartilage degeneration in an osteoarthritis model: an in vivo and in vitro study on lubricin expression

Musumeci, Giuseppe; Trovato, Francesca M.; Pichler, Karin; Weinberg, Annelie M.; Loreto, Carla; Castrogiovanni, Paola

doi:10.1016/j.jnutbio.2013.07.007

Cited by 121 publications

(117 citation statements)

References 68 publications

Supporting

Mentioning

111

Contrasting

Unclassified

Order By: Relevance

“…It is essentially linked to an imbalance between excessive cartilage damage and the ability of cartilage to "heal", but involves and compromises the whole joint, in all its aspects, both macroscopic and microscopic changes (Figure 2) [29][30][31] . Risk factors include age [32,33] , mechanical factors [33] , obesity [34] , and inflammation [35,36] . The key intervention in the management of OA is exercise therapy [37,38] .…”

Section: Rheumatic Diseasesmentioning

confidence: 99%

“…Moreover, in order to preserve the articular cartilage, physicians should promote a healthy lifestyle. Physical activity (mild exercise) must be associated to a balanced diet, such as Mediterranean Diet (olive oil and red orange), in order to prevent and reduce the progression of rheumatic and OA disease [35,[44][45][46][47] .…”

Section: Physiatric Rehabilitation Therapymentioning

confidence: 99%

See 1 more Smart Citation

Effects of exercise on physical limitations and fatigue in rheumatic diseases

Musumeci

2015

WJO

Self Cite

View full text Add to dashboard Cite

Physical activity covers not just sports but also simple everyday movements such as housework, walking and playing. Regular exercise has a great importance in maintaining good health, indeed inactivity is a risk factor for different chronic diseases. Physical exercise can play a crucial role in the treatment of rheumatic diseases, optimizing both physical and mental health, enhancing energy, decreasing fatigue and improving sleep. An exercise program for patients with rheumatic diseases aims to preserve or restore a range of motion of the affected joints, to increase muscle strength and endurance, and to improve mood and decrease health risks associated with a sedentary lifestyle. In this editorial I describe the benefits of the exercise on physical limitations and fatigue in rheumatic diseases that seem to have a short and long-term effectiveness. A literature review was conducted on PubMed, Scopus and Google Scholar using appropriate keywords based on the present editorial.

show abstract

Section: Rheumatic Diseasesmentioning

confidence: 99%

Section: Physiatric Rehabilitation Therapymentioning

confidence: 99%

Effects of exercise on physical limitations and fatigue in rheumatic diseases

Musumeci

2015

WJO

Self Cite

View full text Add to dashboard Cite

show abstract

“…As reported above, age-related apoptotic pathways in skeletal muscle are many and not always clear. However, a lot of studies have been performed in the last decades, in order to establish if an appropriate lifestyle can improve the status of the musculoskeletal system during aging [68]. In this regard, physical activity and nutrition are two focuses highly considered.…”

Section: Exercisementioning

confidence: 99%

Sarcopenia and Exercise “The State of the Art”

Musumeci

2017

JFMK

Self Cite

View full text Add to dashboard Cite

Skeletal muscle mass reduction might be a consequence of aging (sarcopenia), disease (cachexia) or inactivity (muscle atrophy). Studying the triggering factors leading to muscle loss is important in developing therapies to preserve muscle tissue function. The loss of skeletal muscle proteins is caused by an imbalance between the rate of their synthesis and degradation. Specifically, the conditions characterized by muscle loss involve an adaptation metabolism of increased protein degradation (cachexia), decreased muscle protein synthesis (inactivity), or alteration in both (sarcopenia). Sarcopenia and exercise is the main topic chosen for this review. This is a huge health problem, poorly discussed in the current literature and the aim of this review is to explain and help readers to better understand the differences between "sarcopenia", "cachexia", "muscle atrophy" and the relative beneficial effects of exercise used as a possible therapeutic intervention. Sarcopenia is a component of the fragility syndrome and indicates a significant health issue related to the progressive decline of muscle tissue quality and strength. Exercise is associated with improved life quality, reduced health problems, and prolonged lifespan. The latter suggests that exercise should be considered a fundamental point in the treatment of pathological skeletal muscle mass reduction. The present scientific contribution also seeks to emphasize to the scientific community the positive effects of the adapted physical activity in the elderly as a possible non-pharmacologic treatment to prevent or treat muscle atrophy.

show abstract

“…Early mobilization helped return the patients more quickly to physical activity, reduce persistent swelling, restore stability, restore range of motion, and improve patient satisfaction with the rehabilitation outcome [58] . Postoperative rehabilitation programs following articular cartilage repair procedures will vary greatly among patients and need to be individualized, based on the nature of the lesion, the unique characteristics of the patient, and the type and detail of each surgical procedure [59] . These programs are based on knowledge of the basic science, anatomy, and biomechanics of articular cartilage as well as the biological course of healing following surgery [59] .…”

Section: Rehabilitationmentioning

confidence: 99%

“…Postoperative rehabilitation programs following articular cartilage repair procedures will vary greatly among patients and need to be individualized, based on the nature of the lesion, the unique characteristics of the patient, and the type and detail of each surgical procedure [59] . These programs are based on knowledge of the basic science, anatomy, and biomechanics of articular cartilage as well as the biological course of healing following surgery [59] . The goal is to restore full function in each patient as quickly as possible by facilitating a healing response without overloading the healing articular cartilage [2] .…”

Section: Rehabilitationmentioning

confidence: 99%