2017
DOI: 10.1016/j.jalz.2017.04.002
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Extracellular low‐n oligomers of tau cause selective synaptotoxicity without affecting cell viability

Abstract: Tau oligomers are toxic to synapses but not lethal to cells.

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Cited by 88 publications
(94 citation statements)
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“…Hence, the trapping of reactive oligomers and their subsequent degradation by tissue-resident microglia would be of great importance to prevent the AD pathology. To form the stable oligomers, hTau40 WT monomers in reducing condition were induced for oligomerization with polyanionic co-factor heparin in PBS (pH 7.4) [51] as represented by diagrammatic workflow (Fig. 1b).…”
Section: Preparation and Stabilization Of Htau40 Wt Oligomersmentioning
confidence: 99%
See 1 more Smart Citation
“…Hence, the trapping of reactive oligomers and their subsequent degradation by tissue-resident microglia would be of great importance to prevent the AD pathology. To form the stable oligomers, hTau40 WT monomers in reducing condition were induced for oligomerization with polyanionic co-factor heparin in PBS (pH 7.4) [51] as represented by diagrammatic workflow (Fig. 1b).…”
Section: Preparation and Stabilization Of Htau40 Wt Oligomersmentioning
confidence: 99%
“…As the truncated Tau [31] and repeat Tau domains [51] have been already reported to form globular oligomeric structures [55], we were interested in identifying the nanostructures of hTau40 WT oligomers. TEM (Fig.…”
Section: Preparation and Stabilization Of Htau40 Wt Oligomersmentioning
confidence: 99%
“…Preclinical models of tauopathy suggest early synaptotoxicity with reduced plasticity and density (Menkes-Caspi et al, 2015), in response to soluble oligomeric tau aggregates (Kaniyappan et al, 2017) and inflammation (Rajendran and Paolicelli, 2018). The toxicity associated with tau pathology leading to synapse loss is complex and involves direct and indirect pathways (reviewed in (Spires-Jones and Hyman, 2014).…”
Section: Discussionmentioning
confidence: 99%
“…Tau is also present extracellularly, in the cerebrospinal fluid (CSF) and interstitial fluid of tauopathy brains and in the conditioned medium of neuronal culture. Extracellular tau species can be toxic to the neurons (Diaz-Hernandez et al, 2010, Kaniyappan et al, 2017 and more importantly, can become pathogenic "seeds" to be taken up by surrounding neurons (Wu et al, 2016, Wang et al, 2017b.…”
Section: Introductionmentioning
confidence: 99%