Extracellular Matrix (ECM) and the Sculpting of Embryonic Tissues

Dzamba, Bette J.; DeSimone, Douglas W.

doi:10.1016/bs.ctdb.2018.03.006

Cited by 88 publications

(62 citation statements)

References 95 publications

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“…The extracellular matrix (ECM) is also important for proper morphogenesis, and if ECM proteins are misfolded or not produced in the proper amounts this could disrupt the cellular assembly of the embryo (Dzamba & DeSimone, 2018; Loganathan et al, 2016). Evidence from mammalian cell culture suggests that temperature can have significant effects on ECM molecules and their regulation (Ito et al, 2014; Wegrowski, 1993) but the in vivo effects on ectotherms has not been examined.…”

Section: Potential Factors Affecting Development At High Temperaturementioning

confidence: 99%

Embryonic canalization and its limits—A view from temperature

Irvine

2020

J Exp Zool Pt B

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Many animals are able to produce similar offspring over a range of environmental conditions. This property of the developmental process has been termed canalization—the channeling of developmental pathways to generate a stable outcome despite varying conditions. Temperature is one environmental parameter that has fundamental effects on cell physiology and biochemistry, yet developmental programs generally result in a stable phenotype under a range of temperatures. On the other hand, there are typically upper and lower temperature limits beyond which the developmental program is unable to produce normal offspring. This review summarizes data on how development is affected by temperature, particularly high temperature, in various animal species. It also brings together information on potential cell biological and developmental genetic factors that may be responsible for developmental stability in varying temperatures, and likely critical mechanisms that break down at high temperature. Also reviewed are possible means for studying temperature effects on embryogenesis and how to determine which factors are most critical at the high‐temperature limits for normal development. Increased knowledge of these critical factors will point to the targets of selection under climate change, and more generally, how developmental robustness in varying environments is maintained.

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Section: Potential Factors Affecting Development At High Temperaturementioning

confidence: 99%

Embryonic canalization and its limits—A view from temperature

Irvine

2020

J Exp Zool Pt B

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“…In zebrafish, Yap1 is involved in the determination of cardiac precursor cells into smooth muscle cell fate via a process that involves the regulation of Elastinb expression (Moriyama et al, 2016). Besides the control of cell identity, ECM contributes to biomechanical properties of tissues (Dzamba and DeSimone, 2018). It is thus possible that piezo is a major regulator of tissue mechanical properties by regulating Yap1 expression.…”

Section: Yap1 and Hippo Pathways Are Regulators Of The Oft Valve Formmentioning

confidence: 99%

Mechanically activated Piezo channels control outflow tract valve development through Yap1 and Klf2-Notch signaling axis

Duchemin

Vignes

Vermot

2019

Preprint

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Mechanical forces are well known for modulating heart valve developmental programs. Yet, it is still unclear how genetic programs and mechanosensation interact during heart valve development. Here, we assessed the mechanosensitive pathways involved during zebrafish outflow tract (OFT) valve development in vivo. Our results show that the hippo effector Yap1, Klf2, and the Notch signaling pathway are all essential for OFT valve morphogenesis in response to mechanical forces, albeit active in different cell layers. Furthermore, we show that Piezo and TRP mechanosensitive channels are essential for regulating these pathways. In addition, live reporters reveal that piezo controls Klf2 and Notch activity in the endothelium and Yap1 expression in the smooth muscle progenitors to coordinate OFT valve morphogenesis. Together, this work identifies a unique morphogenetic program during OFT valve formation and places Piezo as a central modulator of the cell response to forces in this process.

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“…This short review will highlight approaches that have yielded altered or new understanding of complex tissue processes. Its focus will be on examples chosen from research from our own laboratory, but we emphasize that there are a number of other outstanding studies in this research area (eg see the following Ref …”

Section: Introductionmentioning

confidence: 99%

Extracellular matrix dynamics in cell migration, invasion and tissue morphogenesis

Yamada

Collins

Walma

et al. 2019

Int J Experimental Path

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This review describes how direct visualization of the dynamic interactions of cells with different extracellular matrix microenvironments can provide novel insights into complex biological processes. Recent studies have moved characterization of cell migration and invasion from classical 2D culture systems into 1D and 3D model systems, revealing multiple differences in mechanisms of cell adhesion, migration and signalling-even though cells in 3D can still display prominent focal adhesions.Myosin II restrains cell migration speed in 2D culture but is often essential for effective 3D migration. 3D cell migration modes can switch between lamellipodial, lobopodial and/or amoeboid depending on the local matrix environment. For example, "nuclear piston" migration can be switched off by local proteolysis, and proteolytic invadopodia can be induced by a high density of fibrillar matrix. Particularly, complex remodelling of both extracellular matrix and tissues occurs during morphogenesis. Extracellular matrix supports self-assembly of embryonic tissues, but it must also be locally actively remodelled. For example, surprisingly focal remodelling of the basement membrane occurs during branching morphogenesis-numerous tiny perforations generated by proteolysis and actomyosin contractility produce a microscopically porous, flexible basement membrane meshwork for tissue expansion. Cells extend highly active blebs or protrusions towards the surrounding mesenchyme through these perforations. Concurrently, the entire basement membrane undergoes translocation in a direction opposite to bud expansion. Underlying this slowly moving 2D basement membrane translocation are highly dynamic individual cell movements. We conclude this review by describing a variety of exciting research opportunities for discovering novel insights into cell-matrix interactions. K E Y W O R D S3D culture, basement membrane remodelling, branching morphogenesis, cell migration, extracellular matrix, invasion

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Extracellular Matrix (ECM) and the Sculpting of Embryonic Tissues

Cited by 88 publications

References 95 publications

Embryonic canalization and its limits—A view from temperature

Embryonic canalization and its limits—A view from temperature

Mechanically activated Piezo channels control outflow tract valve development through Yap1 and Klf2-Notch signaling axis

Extracellular matrix dynamics in cell migration, invasion and tissue morphogenesis

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