Extracellular matrix in synovium development, homeostasis and arthritis disease

Qi, Wei; Zhu, Xiaoqin; Wang, Luping; Zhang, Wankang; Yang, Xiaofang; Wei, Wei

doi:10.1016/j.intimp.2023.110453

Cited by 9 publications

(1 citation statement)

References 134 publications

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“…A healthy synovium consists of 1–2 linings of synoviocytes [ 14 , 15 , 16 ]. During inflammation, various mononuclear cells, such as T cells, B cells, dendritic cells, plasma cells, mast cells, and macrophages, infiltrate the site of inflammation ( Figure 1 ) [ 17 , 18 , 19 , 20 ]; the synovial lining becomes hyperplastic, resulting in expansion of the synovial membrane and the formation of villi [ 21 , 22 , 23 ]. Macrophage-like synoviocytes produce various proinflammatory cytokines, such as Interleukin (IL)-1, IL-6, and tumor necrosis factor (TNF).…”

Section: Introductionmentioning

confidence: 99%

A Review of Advances in Molecular Imaging of Rheumatoid Arthritis: From In Vitro to Clinic Applications Using Radiolabeled Targeting Vectors with Technetium-99m

Ali,

Benfante,

Di Raimondo

et al. 2024

Life

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Rheumatoid arthritis (RA) is a systemic autoimmune disorder caused by inflammation of cartilaginous diarthrodial joints that destroys joints and cartilage, resulting in synovitis and pannus formation. Timely detection and effective management of RA are pivotal for mitigating inflammatory arthritis consequences, potentially influencing disease progression. Nuclear medicine using radiolabeled targeted vectors presents a promising avenue for RA diagnosis and response to treatment assessment. Radiopharmaceutical such as technetium-99m (99mTc), combined with single photon emission computed tomography (SPECT) combined with CT (SPECT/CT), introduces a more refined diagnostic approach, enhancing accuracy through precise anatomical localization, representing a notable advancement in hybrid molecular imaging for RA evaluation. This comprehensive review discusses existing research, encompassing in vitro, in vivo, and clinical studies to explore the application of 99mTc radiolabeled targeting vectors with SPECT imaging for RA diagnosis. The purpose of this review is to highlight the potential of this strategy to enhance patient outcomes by improving the early detection and management of RA.

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Section: Introductionmentioning

confidence: 99%

A Review of Advances in Molecular Imaging of Rheumatoid Arthritis: From In Vitro to Clinic Applications Using Radiolabeled Targeting Vectors with Technetium-99m

Ali,

Benfante,

Di Raimondo

et al. 2024

Life

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Bridging the Diagnostic Gap for Hypermobile Ehlers‐Danlos Syndrome and Hypermobility Spectrum Disorders: Evidence of a Common Extracellular Matrix Fragmentation Pattern in Patient Plasma as a Potential Biomarker

Ritelli,

Chiarelli,

Cinquina

et al. 2024

American J of Med Genetics Pt A

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Diagnosing hypermobile Ehlers‐Danlos syndrome (hEDS) and hypermobility spectrum disorders (HSD), common overlapping multisystemic conditions featuring symptomatic joint hypermobility, is challenging due to lack of established causes and diagnostic tools. Currently, the 2017 diagnostic criteria for hEDS are used, with non‐qualifying cases classified as HSD, although the distinction remains debated. We previously showed extracellular matrix (ECM) disorganization in both hEDS and HSD dermal fibroblasts involving fibronectin (FN), type I collagen (COLLI), and tenascin (TN), with matrix metalloproteinase‐generated fragments in conditioned media. Here, we investigated these fragments in patient plasma using Western blotting across diverse cohorts, including patients with hEDS, HSD, classical EDS (cEDS), vascular EDS (vEDS), rheumatoid arthritis (RA), psoriatic arthritis (PsA), and osteoarthritis (OA), and healthy donors, uncovering distinctive patterns. Notably, hEDS/HSD displayed a shared FN and COLLI fragment signature, supporting their classification as a single disorder and prompting reconsideration of the hEDS criteria. Our results hold the promise for the first blood test for diagnosing hEDS/HSD, present insights into the pathomechanisms, and open the door for therapeutic trials focused on restoring ECM homeostasis using an objective marker. Additionally, our findings offer potential biomarkers also for OA, RA, and PsA, advancing diagnostic and therapeutic strategies in these prevalent joint diseases.

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Osteoarthritis: Pathophysiology and Classification of a Common Disabling Condition

O’Sullivan

2024

The Palgrave Encyclopedia of Disability

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Extracellular matrix in synovium development, homeostasis and arthritis disease

Cited by 9 publications

References 134 publications

A Review of Advances in Molecular Imaging of Rheumatoid Arthritis: From In Vitro to Clinic Applications Using Radiolabeled Targeting Vectors with Technetium-99m

A Review of Advances in Molecular Imaging of Rheumatoid Arthritis: From In Vitro to Clinic Applications Using Radiolabeled Targeting Vectors with Technetium-99m

Bridging the Diagnostic Gap for Hypermobile Ehlers‐Danlos Syndrome and Hypermobility Spectrum Disorders: Evidence of a Common Extracellular Matrix Fragmentation Pattern in Patient Plasma as a Potential Biomarker

Osteoarthritis: Pathophysiology and Classification of a Common Disabling Condition

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