2017
DOI: 10.1164/rccm.201612-2480oc
|View full text |Cite
|
Sign up to set email alerts
|

Extracellular Mitochondrial DNA Is Generated by Fibroblasts and Predicts Death in Idiopathic Pulmonary Fibrosis

Abstract: These findings demonstrate a previously unrecognized and highly novel connection between metabolic reprogramming, mtDNA, fibroblast activation, and clinical outcomes that provides new insight into IPF.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
5

Citation Types

4
146
0

Year Published

2018
2018
2023
2023

Publication Types

Select...
5
1

Relationship

1
5

Authors

Journals

citations
Cited by 144 publications
(150 citation statements)
references
References 51 publications
4
146
0
Order By: Relevance
“…Another important pathological feature of mitochondrial dysfunction is the cellular release of fragmented, oxidised mtDNA, which acts as danger associated molecular pattern (DAMP) . IPF‐LFs in culture, when compared to Ctrl‐LF, release increased amounts of mtDNA . Furthermore, BALF and serum levels of mtDNA are higher in patients with IPF, as compared to control donors, with serum levels being predictive of all‐cause mortality …”
Section: Discussionmentioning
confidence: 99%
See 4 more Smart Citations
“…Another important pathological feature of mitochondrial dysfunction is the cellular release of fragmented, oxidised mtDNA, which acts as danger associated molecular pattern (DAMP) . IPF‐LFs in culture, when compared to Ctrl‐LF, release increased amounts of mtDNA . Furthermore, BALF and serum levels of mtDNA are higher in patients with IPF, as compared to control donors, with serum levels being predictive of all‐cause mortality …”
Section: Discussionmentioning
confidence: 99%
“…IPF‐LFs in culture, when compared to Ctrl‐LF, release increased amounts of mtDNA . Furthermore, BALF and serum levels of mtDNA are higher in patients with IPF, as compared to control donors, with serum levels being predictive of all‐cause mortality …”
Section: Discussionmentioning
confidence: 99%
See 3 more Smart Citations