Extracellular phase separation mediates storage and release of thyroglobulin in the thyroid follicular lumen
Yihan Yao,
Nadia Erkamp,
Tomas Sneideris
et al.
Abstract:Thyroid hormones are produced by the thyroid gland and are essential for regulating metabolism, growth and development. Maintenance of circulating thyroid hormone levels within an appropriate range is thus a prerequisite for health. In vivo, this objective is, at least in part, facilitated through an extracellular storage depot of thyroglobulin, the glycoprotein precursor for thyroid hormones, in the thyroid follicular lumen. The molecular basis for how soluble thyroglobulin molecules form such dense depot ass… Show more
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